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Modelling Multiple Dosing with Drug Holiday in Antiretroviral Treatment on HIV-1 Infection

Journal of Mathematical and Fundamental Sciences · Vol. 49 No. 1 (2017) · hlm. 1–17

DOI
10.5614/j.math.fund.sci.2017.49.1.1
ISSN
2338-5510, 2337-5760
Terbit
2017-04-06
Penerbit
Directorate for Research and Innovation (DRI) ITB
Bahasa
eng

Abstrak

A within-host mathematical model to describe the dynamics of target cells and viral load in early HIV-1 infection was developed, which incorporates a combination of RTI and PI treatments by using a pharmacokinetics model. The local stability of uninfected steady state for the model was determined using an alternative threshold. The pharmacokinetics model was employed to estimate drug efficacy in multiple drug dosing. The effect of periodic drug efficacy of pharmacokinetic type on outcome of HIV-1 infection was explored under various treatment interruptions. The effectiveness of treatment interruption was determined according to the time period of the drug holidays. The results showed that long drug holidays lead to therapy failure. Under interruption of treatments combining RTI and PI therapy, effectiveness of the treatment requires a short duration of the drug holiday.

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  • Bandung Institute of Technology
  • Diponegoro University
  • Institut Teknologi Sepuluh Nopember
  • University of KwaZulu-Natal
  • Tadulako University
  • Khalifa University of Science and Technology
  • Norwegian University of Science and Technology
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Rekan penulisOrganisasiArtikel bersama
Muhammad FakhruddinBandung Institute of Technology4
Edy SoewonoBandung Institute of Technology3
Kamal Khairudin SukandarBandung Institute of Technology3
Rudy KusdiantaraBandung Institute of Technology2
Mochamad ApriBandung Institute of Technology2
Hadi SusantoKhalifa University of Science and Technology2
Venansius Ryan TjahjonoInstitut Teknologi Sepuluh Nopember2
Agus HasanNorwegian University of Science and Technology2
Yuki Novia NasutionMulawarman University2
Juni Wijayanti PuspitaTadulako University2
Hilda FahlenaBandung Institute of Technology2
Mia Siti KhumaerohSunan Gunung Djati State Islamic University Bandung1
Redemtus Heru TjahjanaDiponegoro University1
Sunarsih SunarsihDiponegoro University1
Ilham Saiful FauziBandung Institute of Technology1
Karunia Putra WijayaUniversity of Koblenz and Landau1
Fatkhur RohimDiponegoro University1
Yenie SyukriyahBandung Institute of Technology1
Endah R.M. PutriInstitut Teknologi Sepuluh Nopember1
H. KurniawanInstitut Teknologi Sepuluh Nopember1
Muhammad KasimUniversity of Oxford1
Vania Mene RisrianiBandung Institute of Technology1
Tjandra AnggraeniBandung Institute of Technology1
Glenn Lahodny Jr.Afiliasi tidak diketahui1
Anita TriskaPadjadjaran University1
Mona ZevikaBandung Institute of Technology1
. FaridaAfiliasi tidak diketahui1
. SudirmanAfiliasi tidak diketahui1
Widya OktavianaBandung Institute of Technology1
Endah PutriAfiliasi tidak diketahui1
WidyastutiAfiliasi tidak diketahui1
Dila PuspitaBandung Institute of Technology1
NadiaAfiliasi tidak diketahui1
Chai Jian TayUniversiti Malaysia Pahang Al-Sultan Abdullah1
Afdol ZikriBandung Institute of Technology1
Sila RizqinaBandung Institute of Technology1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journals.itb.ac.id/index.php/jmfs/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Modelling Multiple Dosing with Drug Holiday in Antiretroviral Treatment on HIV-1 Infection</dc:title>
	<dc:creator>Sutimin, Sutimin</dc:creator>
	<dc:creator>Nuraini, Nuning</dc:creator>
	<dc:creator>Chirove, Faraimunashe</dc:creator>
	<dc:creator>Suromo, Lisyani Budipradigda</dc:creator>
	<dc:subject xml:lang="en-US">CD4 T cells</dc:subject>
	<dc:subject xml:lang="en-US">drug holiday</dc:subject>
	<dc:subject xml:lang="en-US">HIV-1</dc:subject>
	<dc:subject xml:lang="en-US">Langerhans</dc:subject>
	<dc:subject xml:lang="en-US">pharmacokinetics</dc:subject>
	<dc:description xml:lang="en-US">A within-host mathematical model to describe the dynamics of target cells and viral load in early HIV-1 infection was developed, which incorporates a combination of RTI and PI treatments by using a pharmacokinetics model. The local stability of uninfected steady state for the model was determined using an alternative threshold. The pharmacokinetics model was employed to estimate drug efficacy in multiple drug dosing. The effect of periodic drug efficacy of pharmacokinetic type on outcome of HIV-1 infection was explored under various treatment interruptions. The effectiveness of treatment interruption was determined according to the time period of the drug holidays. The results showed that long drug holidays lead to therapy failure. Under interruption of treatments combining RTI and PI therapy, effectiveness of the treatment requires a short duration of the drug holiday. </dc:description>
	<dc:publisher xml:lang="en-US">Directorate for Research and Innovation (DRI) ITB</dc:publisher>
	<dc:date>2017-04-06</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journals.itb.ac.id/index.php/jmfs/article/view/2132</dc:identifier>
	<dc:identifier>10.5614/j.math.fund.sci.2017.49.1.1</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Mathematical and Fundamental Sciences; Vol. 49 No. 1 (2017); 1-17</dc:source>
	<dc:source>2338-5510</dc:source>
	<dc:source>2337-5760</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journals.itb.ac.id/index.php/jmfs/article/view/2132/1846</dc:relation>
</oai_dc:dc>