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Cytotoxic Activities of Extracts and Isolated Compounds of Some Potential Sumatran Medicinal Plants against MCF-7 and HSC-3 Cell Lines

Journal of Mathematical and Fundamental Sciences · Vol. 51 No. 3 (2019) · hlm. 225–242

DOI
10.5614/j.math.fund.sci.2019.51.3.2
ISSN
2338-5510, 2337-5760
Terbit
2019-12-31
Penerbit
Directorate for Research and Innovation (DRI) ITB
Bahasa
eng

Abstrak

In continuation of our study of Sumatran plants and the bioactivity of their constituents, Stereocaulon halei Lamb (Stereocaulaceae) was extracted and isolated to obtain atranorin (1), lobaric acid (6), and methyl-β-orcinol carboxylate (9). We also prepared methanolic extracts of some Sumatran medicinal plants, i.e. Alpinia denticulata, Alpinia malaccensis, Alpinia submutica, Curcuma zedoaria, Centella asiatia, Mangifera indica, Piper crocatum, Mussaenda frondosa, together with previously isolated compounds, i.e. crocatin A (2) and crocatin B (3) from P. crocatum, curcumin (4) from Curcuma longa, demethoxymatteucinol (5) from Sphaerostephanos polycarpus, mangiferin (7) from M. indica, methyl caffeate (8) from Balanophora elongata, tiliroside (10) from Guazuma ulmifolia, and usnic acid from Usnea sp (11). These extracts and compounds were tested for their cytotoxicity against MCF-7 and HSC-3 cell lines by MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). It was found that the IC50 value of atranorin (1), lobaric acid (6), methyl-β-orcinol carboxylate (9), and methanolic extract of A. submutica towards the MCF-7 cell line was 208.20 µM, 172.05 µM, 382.60 µM and 70.95 µg/mL, respectively. The IC50 value of lobaric acid (6) and methyl-β-orcinol carboxylate (9) against the HSC-3 cell line was 88.92 µM and 260.09 µM, respectively. The other extracts did not show significant cytotoxicity.

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  • Andalas University
  • Yarsi University
  • Universitas Sumatera Utara
  • International Islamic University Malaysia
  • Universiti Sains Malaysia
  • Medan Area University
  • Bandung Institute of Technology
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Rekan penulisOrganisasiArtikel bersama
NofrizalAfiliasi tidak diketahui2
Nanda PutraBandung Institute of Technology2
Goldha FaroliuAndalas University2
Nova SyafniAndalas University2
Ridhayani HattaYarsi University1
Mohamad Arif Budiman Putra PratamaAfiliasi tidak diketahui1
Nurfianti NurfiantiUniversiti Sains Malaysia1
Fathimah AzzahraYarsi University1
Wastuti Hidayati SuriyahYarsi University1
Dede ArsistaYarsi University1
Dwi SuryantoUniversitas Sumatera Utara1
DEDI PRIMA PUTRAAfiliasi tidak diketahui1
Kiki NurtjahjaUniversitas Sumatera Utara1
Tata Bintara KelanaMedan Area University1
Nunuk PriyaniUniversitas Sumatera Utara1
GINTA RIOUniversitas Sumatera Utara1
Dian HandayaniAfiliasi tidak diketahui1
Siswanto SiswantoHasanuddin University1
Heder DjamaludinUniversity of Brawijaya1
Muh Ade ArtasastaState University of Malang1
Akmal DjamaanAndalas University1
Yanwirasti YanwirastiAndalas University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journals.itb.ac.id/index.php/jmfs/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Cytotoxic Activities of Extracts and Isolated Compounds of Some Potential Sumatran Medicinal Plants against MCF-7 and HSC-3 Cell Lines</dc:title>
	<dc:creator>Andania, Meiridha Mutiara</dc:creator>
	<dc:creator>Ismed, Friardi</dc:creator>
	<dc:creator>Taher, Muhammad</dc:creator>
	<dc:creator>Arief Ichwan, Solachuddin Jauhari</dc:creator>
	<dc:creator>Bakhtiar, Amri</dc:creator>
	<dc:creator>Arbain, Dayar</dc:creator>
	<dc:subject xml:lang="en-US">cytotoxic</dc:subject>
	<dc:subject xml:lang="en-US">extracts</dc:subject>
	<dc:subject xml:lang="en-US">HSC-3</dc:subject>
	<dc:subject xml:lang="en-US">isolated compounds</dc:subject>
	<dc:subject xml:lang="en-US">MCF-7</dc:subject>
	<dc:subject xml:lang="en-US">Sumatran medicinal plants</dc:subject>
	<dc:description xml:lang="en-US">In continuation of our study of Sumatran plants and the bioactivity of their constituents, Stereocaulon halei Lamb (Stereocaulaceae) was extracted and isolated to obtain atranorin (1), lobaric acid (6), and methyl-β-orcinol carboxylate (9). We also prepared methanolic extracts of some Sumatran medicinal plants, i.e. Alpinia denticulata, Alpinia malaccensis, Alpinia submutica, Curcuma zedoaria, Centella asiatia, Mangifera indica, Piper crocatum, Mussaenda frondosa, together with previously isolated compounds, i.e. crocatin A (2) and crocatin B (3) from P. crocatum, curcumin (4) from Curcuma longa, demethoxymatteucinol (5) from Sphaerostephanos polycarpus, mangiferin (7) from M. indica, methyl caffeate (8) from Balanophora elongata, tiliroside (10) from Guazuma ulmifolia, and usnic acid from Usnea sp (11). These extracts and compounds were tested for their cytotoxicity against MCF-7 and HSC-3 cell lines by MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). It was found that the IC50 value of atranorin (1), lobaric acid (6), methyl-β-orcinol carboxylate (9), and methanolic extract of A. submutica towards the MCF-7 cell line was 208.20 µM, 172.05 µM, 382.60 µM and 70.95 µg/mL, respectively. The IC50 value of lobaric acid (6) and methyl-β-orcinol carboxylate (9) against the HSC-3 cell line was 88.92 µM and 260.09 µM, respectively. The other extracts did not show significant cytotoxicity.</dc:description>
	<dc:publisher xml:lang="en-US">Directorate for Research and Innovation (DRI) ITB</dc:publisher>
	<dc:date>2019-12-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journals.itb.ac.id/index.php/jmfs/article/view/8823</dc:identifier>
	<dc:identifier>10.5614/j.math.fund.sci.2019.51.3.2</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Mathematical and Fundamental Sciences; Vol. 51 No. 3 (2019); 225-242</dc:source>
	<dc:source>2338-5510</dc:source>
	<dc:source>2337-5760</dc:source>
	<dc:source>10.5614/j.math.fund.sci.2019.51.3</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journals.itb.ac.id/index.php/jmfs/article/view/8823/4193</dc:relation>
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