Effects of Root Extract of Ruellia tuberosa L. on Kidneys of Diabetic Rats

Safitri, Anna; Srihardyastutie, Arie; Roosdiana, Anna; Aulanni`am, Aulanni`am; Octaviana, Eva Nur Laili

doi:10.5614/j.math.fund.sci.2019.51.2.3

Jurnal SINTA 1

Effects of Root Extract of Ruellia tuberosa L. on Kidneys of Diabetic Rats

Journal of Mathematical and Fundamental Sciences · Vol. 51 No. 2 (2019) · hlm. 127–137

DOI: 10.5614/j.math.fund.sci.2019.51.2.3
ISSN: 2338-5510, 2337-5760
Terbit: 2019-08-06
Penerbit: Directorate for Research and Innovation (DRI) ITB
Bahasa: eng

Abstrak

The aim of this research was to study the antidiabetic activity of root extract of Ruellia tuberosa L. on rats (Rattus novergicus) induced by multiple low doses of streptozotocin. The parameters investigated were blood glucose levels, protease activities, and the histopathologic profiles of the kidneys. Three groups of rats, i.e. control, diabetic, and treatment, were used. R. tuberosa L. extracts were given orally for treatment at a dose of 250 mg/kg body weight per day for 21 consecutive days. The induced diabetes group treated with root extract of R. tuberosa L. (group III) had 60.3% lower glucose levels (119 mg/dL) compared to the group with induced diabetes only. Moreover, antidiabetic activity of R. tuberosa L extract was evidenced by the 55% lower protease activity in the treatment group compared to the untreated diabetic group. Finally, a positive effect from root extract of R. tuberosa L. was shown from the less damaged renal glomerulus and smaller gap between extracellular matrices and epithelium cells in the histopathologic profiles of the kidneys in the extract treatment group. These results show the potential of root extract of R. tuberosa L. as a natural product anti-diabetic agent.

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21 penulis · 44 tautan kepenulisan bersama · 8 lintas organisasi

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University of Brawijaya
Universitas Mulia
Universitas Ibrahimy
Suranaree University of Technology
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Rekan penulis	Organisasi	Artikel bersama
Siti Mariyah Ulfa	University of Brawijaya	2
Sutrisno Sutrisno	University of Brawijaya	1
Izaz Aqeiluz Zahara	University of Brawijaya	1
Sofi Nabila	University of Brawijaya	1
Tri Ardiyati	Afiliasi tidak diketahui	1
Aulanni’am Aulanni’am	University of Brawijaya	1
Barlah Rumhayati	University of Brawijaya	1
Dwi Rakhmatun Sulistiyaningrum	University of Brawijaya	1
Irfan Mustafa	University of Brawijaya	1
Nishia Waya Meray	Universitas Mulia	1
Dewi Ratih Tirto Sari	Universitas Ibrahimy	1
Fatchiyah Fatchiyah	University of Brawijaya	1
James R. Ketudat Cairns	Suranaree University of Technology	1
Masruri Masruri	University of Brawijaya	1
Siti Nurul Afifah	University of Brawijaya	1
Moh. Farid Rahman	University of Brawijaya	1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journals.itb.ac.id/index.php/jmfs/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.

Metadata asli (oai_dc)

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	<dc:title xml:lang="en-US">Effects of Root Extract of Ruellia tuberosa L. on Kidneys of Diabetic Rats</dc:title>
	<dc:creator>Safitri, Anna</dc:creator>
	<dc:creator>Srihardyastutie, Arie</dc:creator>
	<dc:creator>Roosdiana, Anna</dc:creator>
	<dc:creator>Aulanni`am, Aulanni`am</dc:creator>
	<dc:creator>Octaviana, Eva Nur Laili</dc:creator>
	<dc:subject xml:lang="en-US">diabetes</dc:subject>
	<dc:subject xml:lang="en-US">diabetic rats</dc:subject>
	<dc:subject xml:lang="en-US">kidneys</dc:subject>
	<dc:subject xml:lang="en-US">protease activities</dc:subject>
	<dc:subject xml:lang="en-US">Ruellia tuberosa L.</dc:subject>
	<dc:description xml:lang="en-US">The aim of this research was to study the antidiabetic activity of root extract of Ruellia tuberosa L. on rats (Rattus novergicus) induced by multiple low doses of streptozotocin. The parameters investigated were blood glucose levels, protease activities, and the histopathologic profiles of the kidneys. Three groups of rats, i.e. control, diabetic, and treatment, were used. R. tuberosa L. extracts were given orally for treatment at a dose of 250 mg/kg body weight per day for 21 consecutive days. The induced diabetes group treated with root extract of R. tuberosa L. (group III) had 60.3% lower glucose levels (119 mg/dL) compared to the group with induced diabetes only. Moreover, antidiabetic activity of R. tuberosa L extract was evidenced by the 55% lower protease activity in the treatment group compared to the untreated diabetic group. Finally, a positive effect from root extract of R. tuberosa L. was shown from the less damaged renal glomerulus and smaller gap between extracellular matrices and epithelium cells in the histopathologic profiles of the kidneys in the extract treatment group. These results show the potential of root extract of R. tuberosa L. as a natural product anti-diabetic agent.</dc:description>
	<dc:publisher xml:lang="en-US">Directorate for Research and Innovation (DRI) ITB</dc:publisher>
	<dc:date>2019-08-06</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journals.itb.ac.id/index.php/jmfs/article/view/9078</dc:identifier>
	<dc:identifier>10.5614/j.math.fund.sci.2019.51.2.3</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Mathematical and Fundamental Sciences; Vol. 51 No. 2 (2019); 127-137</dc:source>
	<dc:source>2338-5510</dc:source>
	<dc:source>2337-5760</dc:source>
	<dc:source>10.5614/j.math.fund.sci.2019.51.2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journals.itb.ac.id/index.php/jmfs/article/view/9078/3858</dc:relation>
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