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Indonesian Micromelum minutum Leave Extracts and Their Cytotoxic Activities toward Breast Cancer Cell Lines

Journal of Mathematical and Fundamental Sciences · Vol. 53 No. 1 (2021) · hlm. 109–117

DOI
10.5614/j.math.fund.sci.2021.53.1.8
ISSN
2338-5510, 2337-5760
Terbit
2021-06-07
Penerbit
Directorate for Research and Innovation (DRI) ITB
Bahasa
eng

Abstrak

Isolation and identification of compounds and pharmacological activity of the Micromelum minutum grown in some countries has been done, but the Indonesian M. minutum has not been studied, either phytochemically or pharmacologically. This study aimed to determine the cytotoxic activity of Indonesian M. minutum leave extracts toward MCF-7 and 4T1 breast cancer cell lines. The leaves were obtained from M. minutum grow in Bantimurung National Park, Bulusaraung, South Sulawesi, and then were macerated gradually in hexane, ethyl acetate, and methanol. The cytotoxic activity of obtained extracts was determined by MTT assay. The extraction yielded hexane (HEM), ethyl acetate (EEM), and methanol (MEM) extracts of 2.65, 6.12, and 6.49%, respectively. HEM was the most potent extract with IC50 values of 148 and 87 µg/mL on MCF-7 and 4T1 cells, respectively, followed by EEM (185 and 170 µg/mL). MEM possessed a weak potency with an IC50 value of 384 µg/mL on MCF-7 cells and was not toxic toward 4T1 cells. Therefore, HEM is important to be further investigated for its active constituents.

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  • Universitas Gadjah Mada
  • Universitas Halu Oleo
  • Indonesian Institute of Sciences
  • Kementerian Kesehatan Republik Indonesia
  • Nara Institute of Science and Technology
  • Atma Jaya University Yogyakarta
  • Muhammadiyah University Purwokerto
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Rekan penulisOrganisasiArtikel bersama
Riris Istighfari JenieUniversitas Gadjah Mada23
Adam HermawanUniversitas Gadjah Mada22
Rohmad Yudi UtomoUniversitas Gadjah Mada10
Dyaningtyas Dewi Pamungkas PutriUniversitas Gadjah Mada10
Faaza Aulia RahmanUniversitas Gadjah Mada8
Sri HandayaniIndonesian Institute of Sciences7
Desty Restia RahmawatiUniversitas Gadjah Mada7
Ummi Maryam ZulfinUniversitas Gadjah Mada6
Sari HaryantiKementerian Kesehatan Republik Indonesia5
Larasati LarasatiUniversitas Gadjah Mada5
Dhania NovitasariUniversitas Gadjah Mada4
Retno MurwantiUniversitas Gadjah Mada4
Erlina RivantiUniversitas Gadjah Mada4
Zalinar UdinIndonesian Institute of Sciences4
Aulia Nur SeptianiUniversitas Gadjah Mada4
Nurull HikmahUniversitas Halu Oleo3
Henny KasmawatiUniversitas Halu Oleo3
La Ode Muhammad FitrawanUniversitas Halu Oleo3
Ruslin RuslinUniversitas Halu Oleo3
Aswani AswaniUniversitas Halu Oleo3
Anindyajati AnindyajatiUniversitas Gadjah Mada3
Sendy JunediAtma Jaya University Yogyakarta3
Yogi ErtantoUniversitas Gadjah Mada3
Ratih Kurnia WardaniUniversitas Gadjah Mada3
Sofa FaridaUniversitas Gadjah Mada3
Fatiha Citra EffendiUniversitas Gadjah Mada3
Suryani SuryaniUniversitas Halu Oleo2
Masashi KawaichiNara Institute of Science and Technology2
Nunuk Aries NurulitaMuhammadiyah University Purwokerto2
Suwijiyo PramonoUniversitas Gadjah Mada2
Lailatul QodriaUniversitas Gadjah Mada2
Gergorius Gena MaranUniversitas Gadjah Mada2
Beni LestariUniversitas Gadjah Mada2
Nur Fitra SariUniversitas Gadjah Mada2
Raisatun Nisa SugiyantoUniversitas Gadjah Mada2

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Sumber metadata: OAI-PMH (metadata jurnal) https://journals.itb.ac.id/index.php/jmfs/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Indonesian Micromelum minutum Leave Extracts and Their Cytotoxic Activities toward Breast Cancer Cell Lines</dc:title>
	<dc:creator>Susidarti, Ratna Asmah</dc:creator>
	<dc:creator>Meiyanto, Edy</dc:creator>
	<dc:creator>Ikawati, Muthi'</dc:creator>
	<dc:creator>Normaidah</dc:creator>
	<dc:creator>Sida, Nurramadhani Armada</dc:creator>
	<dc:subject xml:lang="en-US">breast cancer cells</dc:subject>
	<dc:subject xml:lang="en-US">cytotoxic</dc:subject>
	<dc:subject xml:lang="en-US">extract</dc:subject>
	<dc:subject xml:lang="en-US">Indonesia</dc:subject>
	<dc:subject xml:lang="en-US">Micromelum minutum</dc:subject>
	<dc:description xml:lang="en-US">Isolation and identification of compounds and pharmacological activity of the Micromelum minutum grown in some countries has been done, but the Indonesian M. minutum has not been studied, either phytochemically or pharmacologically. This study aimed to determine the cytotoxic activity of Indonesian M. minutum leave extracts toward MCF-7 and 4T1 breast cancer cell lines. The leaves were obtained from M. minutum grow in Bantimurung National Park, Bulusaraung, South Sulawesi, and then were macerated gradually in hexane, ethyl acetate, and methanol. The cytotoxic activity of obtained extracts was determined by MTT assay. The extraction yielded hexane (HEM), ethyl acetate (EEM), and methanol (MEM) extracts of 2.65, 6.12, and 6.49%, respectively. HEM was the most potent extract with IC50 values of 148 and 87 µg/mL on MCF-7 and 4T1 cells, respectively, followed by EEM (185 and 170 µg/mL). MEM possessed a weak potency with an IC50 value of 384 µg/mL on MCF-7 cells and was not toxic toward 4T1 cells. Therefore, HEM is important to be further investigated for its active constituents.</dc:description>
	<dc:publisher xml:lang="en-US">Directorate for Research and Innovation (DRI) ITB</dc:publisher>
	<dc:date>2021-06-07</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journals.itb.ac.id/index.php/jmfs/article/view/13154</dc:identifier>
	<dc:identifier>10.5614/j.math.fund.sci.2021.53.1.8</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Mathematical and Fundamental Sciences; Vol. 53 No. 1 (2021); 109-117</dc:source>
	<dc:source>2338-5510</dc:source>
	<dc:source>2337-5760</dc:source>
	<dc:source>10.5614/j.math.fund.sci.2021.53.1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journals.itb.ac.id/index.php/jmfs/article/view/13154/5236</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2021 Journal of Mathematical and Fundamental Sciences</dc:rights>
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