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Chemical Constituents of Indonesian Micromelum minutum Leaves and Their Cytotoxicity Against MCF-7 and 4T1 Breast Cancer Cells

Journal of Mathematical and Fundamental Sciences · Vol. 53 No. 1 (2021) · hlm. 97–108

DOI
10.5614/j.math.fund.sci.2021.53.1.7
ISSN
2338-5510, 2337-5760
Terbit
2021-06-07
Penerbit
Directorate for Research and Innovation (DRI) ITB
Bahasa
eng

Abstrak

Micromelum minutum is used widely in traditional folk medicine. Although this species has been investigated extensively and several bioactive compounds have been isolated, little work has been done on Indonesian M. minutum. This research aimed to study the chemical constituents and biological activities of M. minutum cultivated in Bantimurung Bulusaraung National Park, South Sulawesi, Indonesia. The isolated compounds were assessed for their cytotoxicity towards MCF-7 and 4T1 cell lines by MTT method. The dried ground leaves of M. minutum were sequentially macerated with n-hexane, ethyl acetate, and methanol. The n-hexane and ethyl acetate extracts contained a flavonoid 5,7-dihydroxy-3,4',8-trimethoxyflavone (1) which inhibited MCF-7 and 4T1 cell viability by 50% at concentrations of 369±8 and 227±5 µM, respectively. Further separation of the ethyl acetate extract by column chromatography yielded acetyldihydromicromelin A (2) and a mixture of dihydromicromelin A (3) and dihydromicromelin B (4), which were not active toward MCF-7 and 4T1 cells.

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  • Universitas Halu Oleo
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Adam HermawanAfiliasi tidak diketahui22
Riris Istighfari JenieAfiliasi tidak diketahui22
Rohmad Yudi UtomoAfiliasi tidak diketahui10
Dyaningtyas Dewi Pamungkas PutriAfiliasi tidak diketahui10
Sri HandayaniUniversity of Brawijaya7
Faaza Aulia RahmanAfiliasi tidak diketahui7
Desty Restia RahmawatiAfiliasi tidak diketahui7
Ummi Maryam ZulfinAfiliasi tidak diketahui6
Sari HaryantiAfiliasi tidak diketahui5
Larasati LarasatiIPB University5
Dhania NovitasariAfiliasi tidak diketahui4
Retno MurwantiAfiliasi tidak diketahui4
Erlina RivantiAfiliasi tidak diketahui4
Zalinar UdinAfiliasi tidak diketahui4
Aulia Nur SeptianiAfiliasi tidak diketahui4
Nurull HikmahUniversitas Halu Oleo3
Henny KasmawatiUniversitas Halu Oleo3
La Ode Muhammad FitrawanUniversitas Halu Oleo3
Ruslin RuslinUniversitas Halu Oleo3
Aswani AswaniUniversitas Halu Oleo3
Anindyajati AnindyajatiAfiliasi tidak diketahui3
Sendy JunediAfiliasi tidak diketahui3
Yogi ErtantoAfiliasi tidak diketahui3
Ratih Kurnia WardaniAfiliasi tidak diketahui3
Sofa FaridaAfiliasi tidak diketahui3
Fatiha Citra EffendiAfiliasi tidak diketahui3
Suryani SuryaniUniversitas Halu Oleo2
Masashi KawaichiAfiliasi tidak diketahui2
Nunuk Aries NurulitaAfiliasi tidak diketahui2
Suwijiyo PramonoAfiliasi tidak diketahui2
Lailatul QodriaAfiliasi tidak diketahui2
Gergorius Gena MaranAfiliasi tidak diketahui2
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Sumber metadata: OAI-PMH (metadata jurnal) https://journals.itb.ac.id/index.php/jmfs/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Chemical Constituents of Indonesian Micromelum minutum Leaves and Their Cytotoxicity Against MCF-7 and 4T1 Breast Cancer Cells</dc:title>
	<dc:creator>Susidarti, Ratna Asmah</dc:creator>
	<dc:creator>Meiyanto, Edy</dc:creator>
	<dc:creator>Ikawati, Muthi'</dc:creator>
	<dc:creator>Normaidah</dc:creator>
	<dc:creator>Sida, Nurramadhani Armada</dc:creator>
	<dc:subject xml:lang="en-US">5,7-dihydroxy-3,4',8-trimethoxyflavone</dc:subject>
	<dc:subject xml:lang="en-US">breast cancer cell line</dc:subject>
	<dc:subject xml:lang="en-US">cytotoxic activity</dc:subject>
	<dc:subject xml:lang="en-US">dihydromicromelin derivatives</dc:subject>
	<dc:subject xml:lang="en-US">Micromelum minutum</dc:subject>
	<dc:description xml:lang="en-US">Micromelum minutum is used widely in traditional folk medicine. Although this species has been investigated extensively and several bioactive compounds have been isolated, little work has been done on Indonesian M. minutum. This research aimed to study the chemical constituents and biological activities of M. minutum cultivated in Bantimurung Bulusaraung National Park, South Sulawesi, Indonesia. The isolated compounds were assessed for their cytotoxicity towards MCF-7 and 4T1 cell lines by MTT method. The dried ground leaves of M. minutum were sequentially macerated with n-hexane, ethyl acetate, and methanol. The n-hexane and ethyl acetate extracts contained a flavonoid 5,7-dihydroxy-3,4',8-trimethoxyflavone (1) which inhibited MCF-7 and 4T1 cell viability by 50% at concentrations of 369±8 and 227±5 µM, respectively. Further separation of the ethyl acetate extract by column chromatography yielded acetyldihydromicromelin A (2) and a mixture of dihydromicromelin A (3) and dihydromicromelin B (4), which were not active toward MCF-7 and 4T1 cells.</dc:description>
	<dc:publisher xml:lang="en-US">Directorate for Research and Innovation (DRI) ITB</dc:publisher>
	<dc:date>2021-06-07</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journals.itb.ac.id/index.php/jmfs/article/view/13158</dc:identifier>
	<dc:identifier>10.5614/j.math.fund.sci.2021.53.1.7</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Mathematical and Fundamental Sciences; Vol. 53 No. 1 (2021); 97-108</dc:source>
	<dc:source>2338-5510</dc:source>
	<dc:source>2337-5760</dc:source>
	<dc:source>10.5614/j.math.fund.sci.2021.53.1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journals.itb.ac.id/index.php/jmfs/article/view/13158/5235</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2021 Journal of Mathematical and Fundamental Sciences</dc:rights>
</oai_dc:dc>