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Ficus elastica Leaf Extract Effect Toward IL-10 and TNF-α as a Preeclampsia Model on Hypoxia-induced EA.hy926

Journal of Mathematical and Fundamental Sciences · Vol. 53 No. 3 (2022) · hlm. 487–496

DOI
10.5614/j.math.fund.sci.2021.53.3.10
ISSN
2338-5510, 2337-5760
Terbit
2022-01-18
Penerbit
Directorate for Research and Innovation (DRI) ITB
Bahasa
eng

Abstrak

Preeclampsia is a pregnancy complication characterized by proteinuria, hypertension, hypoxia as well an increased systemic inflammatory response. It affects 5 to 10% of all births and is a leading factor in fetal and maternal morbidity and death. Ficus elastica L. leaves are known to have natural compounds with anti-inflammatory and antioxidant properties. This research assessed the potential of F. elastica leaf extract (FEE) as anti-inflammatory agent in a hypoxic-induced human endothelial cell line (EA.hy926) as preeclampsia model. F. elastica leaves were extracted using 70% ethanol. Cytotoxic assay of the FEE in different concentrations (3.13 to 100 µg/ml) against EA.hy926 was done using MTS assay. The FEE’s anti-inflammatory activity was measured with ELISA for the TNF-α and IL-10 parameters. The FEE did not cause cytotoxicity to the EA.hy926 cells, with viability above 80% at the highest concentration. The FEE could decrease the pro-inflammatory TNF-α level and increase the IL-10 level as anti-inflammatory markers in the preeclampsia model at significance level p < 0.05. This study suggests that FEE is a safe alternative herbal medicine for preeclampsia treatment.

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  • Universitas Prima Indonesia
  • Maranatha Christian University
  • Bandung Institute of Technology
  • University of Indonesia
  • Indonesian Institute of Sciences
  • Padjadjaran University
  • Universitas Jenderal Achmad Yani
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Rekan penulisOrganisasiArtikel bersama
Hanna Sari Widya KusumaAfiliasi tidak diketahui13
Ervi AfifahAfiliasi tidak diketahui12
Tjandrawati MozefIndonesian Institute of Sciences7
Teresa Liliana WargasetiaMaranatha Christian University7
Diana Krisanti JasaputraMaranatha Christian University7
Dhanar Septyawan HadiprasetyoUniversitas Jenderal Achmad Yani6
Didik PriyandokoIndonesia University of Education6
Adek AmansyahUniversitas Prima Indonesia6
Ahmad FariedPadjadjaran University6
Dwi Davidson RihibihaAfiliasi tidak diketahui6
Harry MurtiAfiliasi tidak diketahui6
Indra BachtiarAfiliasi tidak diketahui6
The Fransiska EltaniaMaranatha Christian University5
Seila ArumwardanaAfiliasi tidak diketahui5
Ali Napiah NasutionUniversitas Prima Indonesia5
Rizal AzisUniversity of Indonesia4
Philips OnggowidjajaMaranatha Christian University4
Ferry SandraUniversitas Trisakti4
Hana RatnawatiMaranatha Christian University3
Edy FachrialUniversitas Prima Indonesia3
Sri Lestari Ramadhani NasutionUniversitas Prima Indonesia3
Lusiana DarsonoMaranatha Christian University3
Ika Adhani SholihahBandung Institute of Technology3
Fadhilah Haifa ZahirohAfiliasi tidak diketahui3
Nadya Nazimuddin PutriUniversitas Prima Indonesia2
Agung NoviantoPadjadjaran University2
Chandra RisdianIndonesian Institute of Sciences2
Putranto ManaluUniversitas Prima Indonesia2
Hafiz Hawari SiregarAfiliasi tidak diketahui1
Agnes Novica Putri SilabanAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://journals.itb.ac.id/index.php/jmfs/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Ficus elastica Leaf Extract Effect Toward IL-10 and TNF-α as a Preeclampsia Model on Hypoxia-induced EA.hy926</dc:title>
	<dc:creator>Ginting, Chrismis Novalinda</dc:creator>
	<dc:creator>Lister, I Nyoman Ehrich</dc:creator>
	<dc:creator>Girsang, Ermi</dc:creator>
	<dc:creator>Mutia, Maya Sari</dc:creator>
	<dc:creator>Lubis, Yolanda Eliza Putri</dc:creator>
	<dc:creator>Amalia, Annisa</dc:creator>
	<dc:creator>Widodo, Wahyu Setia</dc:creator>
	<dc:creator>Artie, Dwi Surya</dc:creator>
	<dc:creator>Rizal, Rizal</dc:creator>
	<dc:creator>Widowati, Wahyu</dc:creator>
	<dc:subject xml:lang="en-US">EA.hy926</dc:subject>
	<dc:subject xml:lang="en-US">Ficus elastica</dc:subject>
	<dc:subject xml:lang="en-US">hypoxia</dc:subject>
	<dc:subject xml:lang="en-US">IL-10</dc:subject>
	<dc:subject xml:lang="en-US">preeclampsia</dc:subject>
	<dc:subject xml:lang="en-US">TNF-α</dc:subject>
	<dc:description xml:lang="en-US">Preeclampsia is a pregnancy complication characterized by proteinuria, hypertension, hypoxia as well an increased systemic inflammatory response. It affects 5 to 10% of all births and is a leading factor in fetal and maternal morbidity and death. Ficus elastica L. leaves are known to have natural compounds with anti-inflammatory and antioxidant properties. This research assessed the potential of F. elastica leaf extract (FEE) as anti-inflammatory agent in a hypoxic-induced human endothelial cell line (EA.hy926) as preeclampsia model. F. elastica leaves were extracted using 70% ethanol. Cytotoxic assay of the FEE in different concentrations (3.13 to 100 µg/ml) against EA.hy926 was done using MTS assay. The FEE’s anti-inflammatory activity was measured with ELISA for the TNF-α and IL-10 parameters. The FEE did not cause cytotoxicity to the EA.hy926 cells, with viability above 80% at the highest concentration. The FEE could decrease the pro-inflammatory TNF-α level and increase the IL-10 level as anti-inflammatory markers in the preeclampsia model at significance level p &amp;lt; 0.05. This study suggests that FEE is a safe alternative herbal medicine for preeclampsia treatment.</dc:description>
	<dc:publisher xml:lang="en-US">Directorate for Research and Innovation (DRI) ITB</dc:publisher>
	<dc:date>2022-01-18</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journals.itb.ac.id/index.php/jmfs/article/view/13498</dc:identifier>
	<dc:identifier>10.5614/j.math.fund.sci.2021.53.3.10</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Mathematical and Fundamental Sciences; Vol. 53 No. 3 (2021); 487-496</dc:source>
	<dc:source>2338-5510</dc:source>
	<dc:source>2337-5760</dc:source>
	<dc:source>10.5614/j.math.fund.sci.2021.53.3</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journals.itb.ac.id/index.php/jmfs/article/view/13498/5615</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Journal of Mathematical and Fundamental Sciences</dc:rights>
</oai_dc:dc>