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Cytotoxic Effect of Benzofuranoid Neolignans from Myristica fragrans Seeds Against Melanoma B16-F10 Cancer Cells

Journal of Mathematical and Fundamental Sciences · Vol. 56 No. 2 (2024) · hlm. 133–143

DOI
10.5614/j.math.fund.sci.2024.56.2.4
ISSN
2338-5510, 2337-5760
Terbit
2024-12-31
Penerbit
Directorate for Research and Innovation (DRI) ITB
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-nd/4.0

Abstrak

Myristica fragrans is an indigenous plant in Indonesia, characterized by various secondary metabolites with diverse bioactivities. This plant possesses promising anti-melanoma properties capable of addressing prevalent cases of melanoma. Therefore, this study’s objective was to isolate potential compounds from Myristica fragrans seeds and assess their cytotoxic effects on melanoma B16-F10 cells. Ethyl acetate extracts were subjected to separation through various chromatographic methods to obtain three benzofuranoid neolignans, which was conducted using spectroscopic analyses, namely UV-vis, polarimeter, HRTOF-MS, IR, and NMR. Subsequently, comparison with previously reported spectral data confirmed the identities of neolignans as (+)-licarin A (1), (+)-licarin B (2), and (+)-maceneolignan B (3). Cytotoxicity against melanoma B16-F10 cells was assessed using the PrestoBlue method, revealing (+)-licarin A (1) to display the most potent activity with an IC50 value of 94.15 μM.

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  • Padjadjaran University
  • National Research and Innovation Agency
  • Yamagata University
  • Universiti Sains Malaysia
  • Mulawarman University
  • Sam Ratulangi University
  • University of Malaya
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Rekan penulisOrganisasiArtikel bersama
Kindi FarabiPadjadjaran University29
Nurlelasari NurlelasariPadjadjaran University26
Tri MayantiPadjadjaran University22
Rani MaharaniPadjadjaran University20
Sofa FajriahNational Research and Innovation Agency17
Al Arofatus NainiPadjadjaran University17
Yoshihito ShionoYamagata University16
Ace Tatang HidayatPadjadjaran University16
Mohamad Nurul AzmiUniversiti Sains Malaysia11
Darwati DarwatiPadjadjaran University10
Hadi KuncoroMulawarman University8
Tati HerlinaPadjadjaran University7
Fajar Fauzi AbdullahPadjadjaran University6
Sandra Amalia RiyadiPadjadjaran University6
Dewa Gede KatjaSam Ratulangi University5
Erina HilmayantiPadjadjaran University5
Khalijah AwangUniversity of Malaya5
Risyandi AnwarUniversitas Muhammadiyah Semarang5
Harizon HarizonUniversitas Jambi5
Euis JulaehaPadjadjaran University4
Ricson P. HutagaolUniversitas Nusa Bangsa4
Rurini RetnowatiUniversity of Brawijaya4
Desi Harneti Putri HuspaPadjadjaran University3
Agus SafariPadjadjaran University3
Muhammad HanafiNational Research and Innovation Agency3
Sari PurbayaUniversitas Jenderal Achmad Yani3
Aprilia Permata SariPadjadjaran University3
Mohamad Azlan NafiahSultan Idris Education University3
Ferry Ferdiansyah SofianPadjadjaran University3
Dadan SumiarsaPadjadjaran University3
Achmad ZainuddinPadjadjaran University3
Arif Rahman HakimPadjadjaran University2
Dikdik KurniaPadjadjaran University2

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Sumber metadata: OAI-PMH (metadata jurnal) https://journals.itb.ac.id/index.php/jmfs/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Cytotoxic Effect of Benzofuranoid Neolignans from Myristica fragrans Seeds Against Melanoma B16-F10 Cancer Cells</dc:title>
	<dc:creator>Hasbilla, Raihan Fathurrahman </dc:creator>
	<dc:creator>Safriansyah, Wahyu  </dc:creator>
	<dc:creator>Susianti, Susianti</dc:creator>
	<dc:creator>Harneti, Desi  </dc:creator>
	<dc:creator>Salam, Suprianto  </dc:creator>
	<dc:creator>Lesmana, Ronny  </dc:creator>
	<dc:creator>Supratman, Unang</dc:creator>
	<dc:subject xml:lang="en-US">B16-F10 Cancer Cells</dc:subject>
	<dc:subject xml:lang="en-US">cytotoxicity</dc:subject>
	<dc:subject xml:lang="en-US">Myristica fragrans</dc:subject>
	<dc:subject xml:lang="en-US">Myristicaceae</dc:subject>
	<dc:subject xml:lang="en-US">neolignans</dc:subject>
	<dc:subject xml:lang="en-US">Natural products chemistry</dc:subject>
	<dc:subject xml:lang="en-US">isolation of secondary metabolites</dc:subject>
	<dc:subject xml:lang="en-US">structural elucidation</dc:subject>
	<dc:subject xml:lang="en-US">cytotoxic activity</dc:subject>
	<dc:description xml:lang="en-US">Myristica fragrans is an indigenous plant in Indonesia, characterized by various secondary metabolites with diverse bioactivities. This plant possesses promising anti-melanoma properties capable of addressing prevalent cases of melanoma. Therefore, this study’s objective was to isolate potential compounds from Myristica fragrans seeds and assess their cytotoxic effects on melanoma B16-F10 cells. Ethyl acetate extracts were subjected to separation through various chromatographic methods to obtain three benzofuranoid neolignans, which was conducted using spectroscopic analyses, namely UV-vis, polarimeter, HRTOF-MS, IR, and NMR. Subsequently, comparison with previously reported spectral data confirmed the identities of neolignans as (+)-licarin A (1), (+)-licarin B (2), and (+)-maceneolignan B (3). Cytotoxicity against melanoma B16-F10 cells was assessed using the PrestoBlue method, revealing (+)-licarin A (1) to display the most potent activity with an IC50 value of 94.15 μM.</dc:description>
	<dc:publisher xml:lang="en-US">Directorate for Research and Innovation (DRI) ITB</dc:publisher>
	<dc:date>2024-12-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journals.itb.ac.id/index.php/jmfs/article/view/23358</dc:identifier>
	<dc:identifier>10.5614/j.math.fund.sci.2024.56.2.4</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Mathematical and Fundamental Sciences; Vol. 56 No. 2 (2024); 133-143</dc:source>
	<dc:source>2338-5510</dc:source>
	<dc:source>2337-5760</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journals.itb.ac.id/index.php/jmfs/article/view/23358/6971</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 Journal of Mathematical and Fundamental Sciences</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-nc-nd/4.0</dc:rights>
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