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Penta- and Tetra-cyclic Triterpenoids from Aglaia cucullata Stembark and Cytotoxicity against Cancer and Normal Cells

Journal of Mathematical and Fundamental Sciences · Vol. 57 No. 2 (2025) · hlm. 86–95

DOI
10.5614/j.math.fund.sci.2025.57.2.1
ISSN
2338-5510, 2337-5760
Terbit
2025-11-29
Penerbit
Directorate for Research and Innovation (DRI) ITB
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-nd/4.0

Abstrak

Three triterpenoid compounds, belonging to the penta- and tetracyclic groups, were successively isolated from the stembark of Aglaia cucullata and identified as b-amyron (1), dammaradienon (2), and cabralealactone (3). After extensive extraction, chromatographic separation and purification, compounds 1 to 3 were gained. Spectroscopic analysis in addition to HRMS, FTIR, 1D and 2D NMR analysis were utilized to determine the chemical structure. After that, compounds 1 to 3 were tested against breast cancer, melanoma as well as normal kidney cells (MCF-7, B16-F10, and CV-1, respectively). The resulted cytotoxicity test revealed that compound 1 had the best cytotoxicity against all cells compared with the other isolated compounds. This result suggests that the pentacyclic triterpenoid core in compound 1 increases cytotoxicity compared with a tetracyclic skeleton.

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  • Padjadjaran University
  • National Research and Innovation Agency
  • Indonesian Institute of Sciences
  • Mulawarman University
  • Yamagata University
  • Universiti Sains Malaysia
  • Sam Ratulangi University
  • Organisasi lain
  • Organisasi berbeda
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Rekan penulisOrganisasiArtikel bersama
Nurlelasari NurlelasariPadjadjaran University44
Tri MayantiPadjadjaran University36
Rani MaharaniPadjadjaran University33
Al Arofatus NainiPadjadjaran University30
Yoshihito ShionoYamagata University26
Ace Tatang HidayatPadjadjaran University22
Mohamad Nurul AzmiUniversiti Sains Malaysia17
Darwati DarwatiPadjadjaran University17
Fajar Fauzi AbdullahPadjadjaran University10
Erina HilmayantiPadjadjaran University10
Euis JulaehaPadjadjaran University9
Dewa Gede KatjaSam Ratulangi University9
Harizon HarizonUniversitas Jambi9
Tati HerlinaPadjadjaran University8
Risyandi AnwarUniversitas Muhammadiyah Semarang8
Khalijah AwangUniversity of Malaya7
Ricson P. HutagaolUniversitas Nusa Bangsa7
Ferry Ferdiansyah SofianPadjadjaran University7
Tjandrawati MozefIndonesian Institute of Sciences5
Gian PrimahanaNational Research and Innovation Agency5
Desi Harneti Putri HuspaPadjadjaran University5
Muhammad HanafiNational Research and Innovation Agency5
Aprilia Permata SariPadjadjaran University5
Mohamad Azlan NafiahSultan Idris Education University5
Sandra Amalia RiyadiPadjadjaran University4
Ronny LesmanaPadjadjaran University4
Raihan Fathurrahman HasbillaPadjadjaran University4
Susianti SusiantiPadjadjaran University4
Agus SafariPadjadjaran University4
Rurini RetnowatiUniversity of Brawijaya4
Akhmad DarmawanIndonesian Institute of Sciences3
Sari PurbayaUniversitas Jenderal Achmad Yani3
Arif Rahman HakimPadjadjaran University2
Dikdik KurniaPadjadjaran University2

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Sumber metadata: OAI-PMH (metadata jurnal) https://journals.itb.ac.id/index.php/jmfs/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Penta- and Tetra-cyclic Triterpenoids from Aglaia cucullata Stembark and Cytotoxicity against Cancer and Normal Cells</dc:title>
	<dc:creator>Farabi, Kindi </dc:creator>
	<dc:creator>Safriansyah, Wahyu </dc:creator>
	<dc:creator>Harneti, Desi</dc:creator>
	<dc:creator>Kuncoro, Hadi</dc:creator>
	<dc:creator>Fajriah, Sofa</dc:creator>
	<dc:creator>Supratman, Unang</dc:creator>
	<dc:subject xml:lang="en-US">Aglaia</dc:subject>
	<dc:subject xml:lang="en-US">Aglaia cucullata</dc:subject>
	<dc:subject xml:lang="en-US">cytotoxic activity</dc:subject>
	<dc:subject xml:lang="en-US">Meliaceae</dc:subject>
	<dc:subject xml:lang="en-US">penta- and tetracyclic triterpenoids</dc:subject>
	<dc:subject xml:lang="en-US">Natural Products Chemistry</dc:subject>
	<dc:description xml:lang="en-US">Three triterpenoid compounds, belonging to the penta- and tetracyclic groups, were successively isolated from the stembark of Aglaia cucullata and identified as b-amyron (1), dammaradienon (2), and cabralealactone (3). After extensive extraction, chromatographic separation and purification, compounds 1 to 3 were gained. Spectroscopic analysis in addition to HRMS, FTIR, 1D and 2D NMR analysis were utilized to determine the chemical structure. After that, compounds 1 to 3 were tested against breast cancer, melanoma as well as normal kidney cells (MCF-7, B16-F10, and CV-1, respectively). The resulted cytotoxicity test revealed that compound 1 had the best cytotoxicity against all cells compared with the other isolated compounds. This result suggests that the pentacyclic triterpenoid core in compound 1 increases cytotoxicity compared with a tetracyclic skeleton.</dc:description>
	<dc:publisher xml:lang="en-US">Directorate for Research and Innovation (DRI) ITB</dc:publisher>
	<dc:date>2025-11-29</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journals.itb.ac.id/index.php/jmfs/article/view/25617</dc:identifier>
	<dc:identifier>10.5614/j.math.fund.sci.2025.57.2.1</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Mathematical and Fundamental Sciences; Vol. 57 No. 2 (2025); 86-95</dc:source>
	<dc:source>2338-5510</dc:source>
	<dc:source>2337-5760</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journals.itb.ac.id/index.php/jmfs/article/view/25617/7185</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 Journal of Mathematical and Fundamental Sciences</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-nc-nd/4.0</dc:rights>
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