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Identifikasi Sifat dan Distribusi Sel Endokrin Ghrelin di Lambung Tikus (Rattus norvegicus): Studi Immunohis-Tokimia pada Kondisi Obesitas

Journal of Tropical Biodiversity and Biotechnology · Vol. 1 No. 1 (2016) · hlm. 39–44

DOI
10.22146/jtbb.12932
ISSN
2540-9581, 2540-9573
Terbit
2016-06-01
Penerbit
Universitas Gadjah Mada
Bahasa
ind

Abstrak

Obesity is one of major nutritional problems in the world. Obesity is very dangerous, especially when concentrated in the abdomen, because it is closely linked to various diseases such as diabetes, hypertension, heart disease, which can to causing death. This study aims to identify the nature and distribution of ghrelin on gastric endocrine cells in the obese rat (Rattus norvegicus) by using immunohistochemical techniques. The results will strengthen the understanding of the role and function of ghrelin as an alternative therapeutic target on obesity. The research used gastric tissues of ten obese and control rats which were stained with avidin-biotin-peroxidase complex method of immunohistochemistry. The results showed the existence of two types of ghrelin-producing cells (open and closed types) on the gastric mucosa of control rats, and only one type of ghrelin producing cells (open type) in obese rats. The intensity of ghrelin immunoreactive positive cells was detected weak in obese rats, but very strong in control rats. Ghrelin endocrine cells mainly distributed in the basal part of the gastric mucosa of the fundus parts, with a very small number in obese rats, but highly abundant in control rats. This study confirmed the decrease of the ghrelin synthesis and secretion in obese rat (Rattus norvegicus) at the cellular level. The decrease of ghrelin synthesis is characterized by a reduction on the number of ghrelin producing cells, the disappearance of the close type of ghrelin producing cells, and the low activity of protein synthesis in the ghrelin producing cells. Ghrelin endocrine cells distributed mainly in the basal part of the gastric mucosa, especially in the fundus parts.

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  • Universitas Gadjah Mada
  • State University of Semarang
  • University of Brawijaya
  • Universitas Esa Unggul
  • Mulawarman University
  • Tunghai University
  • National Research and Innovation Agency
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Rekan penulisOrganisasiArtikel bersama
Ulayatul KustiatiUniversity of Brawijaya4
Budi Setiadi DaryonoUniversitas Gadjah Mada2
Nastiti WijayantiUniversitas Gadjah Mada2
Aris Tri HaryantoUniversitas Gadjah Mada2
Dwi Liliek KusindartaUniversitas Gadjah Mada2
Abdul Rahman SiregarUniversitas Gadjah Mada1
Muhammad Fauzi ArifMulawarman University1
Azizah Tyas NugrahantyUniversitas Gadjah Mada1
Lucia Arum Sekar MeysariUniversitas Gadjah Mada1
Bagas Alfian DwiaryandaUniversitas Gadjah Mada1
Arief MuammarUniversitas Gadjah Mada1
AFIF PRANAYA JATIUniversitas Esa Unggul1
Imam Bagus NugrohoUniversitas Gadjah Mada1
Hong‐Wei YenTunghai University1
Yunita Dyah Puspita SantikState University of Semarang1
Devita Uzlah SibaraniState University of Semarang1
Sherly GusnawanState University of Semarang1
Lutfi MuzaqiState University of Semarang1
Dyah SukendraState University of Semarang1
Nungki Hapsari SuryaningtyasNational Research and Innovation Agency1
Beni ErnawanNational Nuclear Energy Agency of Indonesia1
Wan Fatma ZuharahUniversiti Sains Malaysia1
Intan Tasya FarasyaAfiliasi tidak diketahui1
Najiha RamadhaniState University of Semarang1
Eldasari Myana YulianingrumState University of Semarang1
Karmilah KarmilahPoliteknik Bina Husada Kendari1
Anggun Diyan NurhasanahUniversitas Gadjah Mada1
Madyan Akmal HidayatUniversitas Gadjah Mada1
Muslifah HasanahUniversitas Gadjah Mada1
Adib Fakhruddin YusufUniversitas Gadjah Mada1
Adristi Shafa WidyasariUniversitas Gadjah Mada1
Ananto Puradi NainggolanUniversitas Gadjah Mada1
Vida Rahma LatifahUniversitas Gadjah Mada1
Vivi Indah NurcahyatiUniversitas Gadjah Mada1
Aldy Riau Wansyah HasibuanUniversitas Gadjah Mada1
Arini Dian PratiwiUniversitas Gadjah Mada1
Rindu AurantikaUniversitas Gadjah Mada1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ugm.ac.id/jtbb/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Identifikasi Sifat dan Distribusi Sel Endokrin Ghrelin di Lambung Tikus (Rattus norvegicus): Studi Immunohis-Tokimia pada Kondisi Obesitas</dc:title>
	<dc:creator>Budipitojo, Teguh</dc:creator>
	<dc:creator>Wihadmadyatami, Hevi</dc:creator>
	<dc:creator>Aristya, Ganies Riza</dc:creator>
	<dc:subject xml:lang="en-US">Ghrelin; Stomach; Obesity; Immunohistochemistry</dc:subject>
	<dc:description xml:lang="en-US">Obesity is one of major nutritional problems in the world. Obesity is very dangerous, especially when concentrated in the abdomen, because it is closely linked to various diseases such as diabetes, hypertension, heart disease, which can to causing death. This study aims to identify the nature and distribution of ghrelin on gastric endocrine cells in the obese rat (Rattus norvegicus) by using immunohistochemical techniques. The results will strengthen the understanding of the role and function of ghrelin as an alternative therapeutic target on obesity. The research used gastric tissues of ten obese and control rats which were stained with avidin-biotin-peroxidase complex method of immunohistochemistry. The results showed the existence of two types of ghrelin-producing cells (open and closed types) on the gastric mucosa of control rats, and only one type of ghrelin producing cells (open type) in obese rats. The intensity of ghrelin immunoreactive positive cells was detected weak in obese rats, but very strong in control rats. Ghrelin endocrine cells mainly distributed in the basal part of the gastric mucosa of the fundus parts, with a very small number in obese rats, but highly abundant in control rats. This study confirmed the decrease of the ghrelin synthesis and secretion in obese rat (Rattus norvegicus) at the cellular level. The decrease of ghrelin synthesis is characterized by a reduction on the number of ghrelin producing cells, the disappearance of the close type of ghrelin producing cells, and the low activity of protein synthesis in the ghrelin producing cells. Ghrelin endocrine cells distributed mainly in the basal part of the gastric mucosa, especially in the fundus parts.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Gadjah Mada</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2016-06-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ugm.ac.id/jtbb/article/view/12932</dc:identifier>
	<dc:identifier>10.22146/jtbb.12932</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Tropical Biodiversity and Biotechnology; Vol 1, No 1 (2016): June; 39-44</dc:source>
	<dc:source>2540-9581</dc:source>
	<dc:source>2540-9573</dc:source>
	<dc:language>ind</dc:language>
	<dc:relation>https://journal.ugm.ac.id/jtbb/article/view/12932/14750</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2016 Journal of Tropical Biodiversity and Biotechnology</dc:rights>
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