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The Potential of Single Garlic Oil in Inhibiting The Growth and Damaging The Membrane of Pseudomonas aeruginosa Bacteria

Journal of Tropical Biodiversity and Biotechnology · Vol. 3 No. 3 (2018) · hlm. 67–72

DOI
10.22146/jtbb.33498
ISSN
2540-9581, 2540-9573
Terbit
2018-12-31
Penerbit
Universitas Gadjah Mada
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Nosocomial infection caused by Pseudomonas aeruginosa bacteria is hard to be treated since the infection transmission is fast and it is resistance to the antibiotic. Antibiotic resistance in the bacteria can be treated with various natural ingredients from plants and one of the plants is single garlic. Single garlic contains organosulfur compounds in form of alliin, allicin, and ajoene. This research aimed to analyze the potential of single garlic oil (SGO) in inhibiting the growth and the damage of membrane of P. aeruginosa bacteria in in vitro with disc diffusion method by giving treatments of essential oil extract in concentration of 25 mg/ml, 50 mg/ml, 75 mg/ml and 100 mg/ml, and 1% dimethylsulfoxide (DMSO) as the negative control and Ceftazidimeof 30 µg/ml as the positive control. The damage of the bacterial cell membrane was observed with Scanning Electron Microscopy (SEM) with a magnification of 25000X. The result of the measurement of the zone of inhibition was analyzed using one-way ANOVA. The research results indicate that SGO could inhibit the growth of P. aeruginosa bacteria with strong criteria, which was in a concentration of 100 mg/ml.

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  • State University of Malang
  • National Yang Ming Chiao Tung University
  • University of Indonesia
  • Universitas Halu Oleo
  • National Research and Innovation Agency
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Rekan penulisOrganisasiArtikel bersama
Hendra SusantoNational Yang Ming Chiao Tung University4
Yuslinda AnnisaAfiliasi tidak diketahui4
Abdul GofurUniversity of Indonesia4
Dewi Sekar MiasihAfiliasi tidak diketahui3
Dina MaulinaAfiliasi tidak diketahui2
Muhammad Sasmito DjatiAfiliasi tidak diketahui2
Yunita RakhmawatiAfiliasi tidak diketahui2
Sunaryono SunaryonoState University of Malang2
Alif Rosyidah El BarorohAfiliasi tidak diketahui2
Siti Nur ArifahAfiliasi tidak diketahui2
Mochammad Fitri Atho'illahAfiliasi tidak diketahui2
Sutiman B SumitroAfiliasi tidak diketahui1
Muhammad AminUniversitas Halu Oleo1
Fatchiyah FatchiyahAfiliasi tidak diketahui1
Ahmad RudijantoAfiliasi tidak diketahui1
Najib MohammedAfiliasi tidak diketahui1
Rony IrawantoNational Research and Innovation Agency1
Hidajah RachmawatiAfiliasi tidak diketahui1
Alif Rosyidah El BarorohAfiliasi tidak diketahui1
Siti ZubaidahState University of Malang1
Sri Endah IndriwatiState University of Malang1
Dewi MurniAfiliasi tidak diketahui1
Paidi PaidiAfiliasi tidak diketahui1
Sutiman Bambang SumitroAfiliasi tidak diketahui1
Dominikus Djago DjoaAfiliasi tidak diketahui1
Abdul GhofurAfiliasi tidak diketahui1
Siti Imroatul MaslikahAfiliasi tidak diketahui1
Amalia Nur RahmaAfiliasi tidak diketahui1
Dahniar Nur AisyahAfiliasi tidak diketahui1
Ikfi Nihayatul MufidahAfiliasi tidak diketahui1
Nadiya Dini RifqiAfiliasi tidak diketahui1
Nenes PrastitaAfiliasi tidak diketahui1
Betty LukiatiAfiliasi tidak diketahui1
Putri Diyah AnggrainiAfiliasi tidak diketahui1
Miftahul MufinadirohAfiliasi tidak diketahui1
Suharti SuhartiAfiliasi tidak diketahui1
Nik Ahmad Nizam Nik MalekAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ugm.ac.id/jtbb/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">The Potential of Single Garlic Oil in Inhibiting The Growth and Damaging The Membrane of Pseudomonas aeruginosa Bacteria</dc:title>
	<dc:creator>Lestari, Sri Rahayu</dc:creator>
	<dc:creator>Witjoro, Agung</dc:creator>
	<dc:creator>Poejiani, Soeyati</dc:creator>
	<dc:subject xml:lang="en-US">Single Garlic Oil Extract (SGO); the zone of inhibition; Pseudomonas aeruginosa</dc:subject>
	<dc:description xml:lang="en-US">Nosocomial infection caused by Pseudomonas aeruginosa bacteria is hard to be treated since the infection transmission is fast and it is resistance to the antibiotic. Antibiotic resistance in the bacteria can be treated with various natural ingredients from plants and one of the plants is single garlic. Single garlic contains organosulfur compounds in form of alliin, allicin, and ajoene. This research aimed to analyze the potential of single garlic oil (SGO) in inhibiting the growth and the damage of membrane of P. aeruginosa bacteria in in vitro with disc diffusion method by giving treatments of essential oil extract in concentration of 25 mg/ml, 50 mg/ml, 75 mg/ml and 100 mg/ml, and 1% dimethylsulfoxide (DMSO) as the negative control and Ceftazidimeof 30 µg/ml as the positive control. The damage of the bacterial cell membrane was observed with Scanning Electron Microscopy (SEM) with a magnification of 25000X. The result of the measurement of the zone of inhibition was analyzed using one-way ANOVA. The research results indicate that SGO could inhibit the growth of P. aeruginosa bacteria with strong criteria, which was in a concentration of 100 mg/ml.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Gadjah Mada</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2018-12-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ugm.ac.id/jtbb/article/view/33498</dc:identifier>
	<dc:identifier>10.22146/jtbb.33498</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Tropical Biodiversity and Biotechnology; Vol 3, No 3 (2018): December; 67-72</dc:source>
	<dc:source>2540-9581</dc:source>
	<dc:source>2540-9573</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ugm.ac.id/jtbb/article/view/33498/23383</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2018 Journal of Tropical Biodiversity and Biotechnology</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</dc:rights>
</oai_dc:dc>