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The Effect of Ethanolic Extract of Cashew Fruit Peel on The Liver Histological Structure in Rat (Rattus norvegicus Berkenhout, 1769)

Journal of Tropical Biodiversity and Biotechnology · Vol. 4 No. 3 (2019) · hlm. 113–118

DOI
10.22146/jtbb.39275
ISSN
2540-9581, 2540-9573
Terbit
2019-12-16
Penerbit
Universitas Gadjah Mada
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Cashew fruit peel is a waste produced from the cashew nut industry, and it has not been utilized optimally yet. Cashew peel extract has the potential to be used as a contraceptive agent, which capable of reducing reproductive capacity. However, its side effects on other tissue and organ such as liver not clearly studied yet. This study aims to determine the effect of ethanolic extracts of cashew peel on the histological structure of the white rat liver. In this study, 21 female white rats were used and be grouped for control (6 mice) which were treated with CMCMa 0.5% and 15 mice were treated with peel extract of 500 mg/kg body every day for one month. Liver for examination was collected sequentially at 3rd, 5th, 8th, 11th, and 14th of the estrous cycle. The liver was processed for histological observation and stained with Hematoxylin Eosin and Mallory Acid Fuchsin staining solution. The liver hepatocyte was observed for it abnormality and be scored to calculate the number of cell damage or abnormality. The result showed that peel extract-treated mouse liver was similar to control ones; we did not witness any evidence of fibrosis, pyknosis and cellular necrosis on either control or treated mouse. Statistical analysis by SPSS showed that the p-value between the control and treatment groups was 0.078 (> 0.05) so there was no significant difference between control and treatment. It could be concluded that ethanolic extracts of cashew nuts peel with a concentration of 500 mg/kg body weight caused no effect on the mouse liver histological structure. application with reduced-dosages of NPK fertilizers were arranged in a random block design with three replicates. The results show that large quantities of silica bodies attached to the surface of EFB fibers and amounting to 0.44% soluble Si. The FFB data indicated that the application of 75% NPK + 500 kg composted EFB + 2 L BioSilAc/ha/year on a five-year-old plant resulted in higher yield than that obtained from 100% standard dosage of NPK. The study also revealed that the application of EFB compost reduced 50% of BioSilAc dosage.

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  • Universitas Gadjah Mada
  • Jenderal Soedirman University
  • National Institute of Technology and Evaluation
  • Justus-Liebig-Universität Gießen
  • Universitas Teuku Umar
  • Universitas Islam Negeri Ar-Raniry
  • The University of Tokyo
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
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Rekan penulisOrganisasiArtikel bersama
Aris Tri HaryantoUniversitas Gadjah Mada7
Tri WibawaUniversitas Gadjah Mada4
Michael KannJustus-Liebig-Universität Gießen3
Jaka WidadaUniversitas Gadjah Mada2
Pradnya ParamitaUniversitas Gadjah Mada2
Luthfia Uswatun KhasanahUniversitas Gadjah Mada2
Hevi WihadmadyatamiUniversitas Gadjah Mada2
Rarastoeti PratiwiUniversitas Gadjah Mada2
Selvi AriyunitaUniversitas Gadjah Mada1
Suwarno HadisusantoUniversitas Gadjah Mada1
Andhika Puspito NugrohoUniversitas Gadjah Mada1
Diani MentariJenderal Soedirman University1
Rinawati RinawatiUniversitas Teuku Umar1
E. SuharyantoUniversitas Gadjah Mada1
Jihan Restu BuanaUniversitas Gadjah Mada1
Muhammad AdnanUniversitas Islam Negeri Ar-Raniry1
Matin NuhamunadaUniversitas Gadjah Mada1
Lisna HidayatiUniversitas Gadjah Mada1
Hera NirwatiUniversitas Gadjah Mada1
Sp.A SutaryoUniversitas Gadjah Mada1
Nenny Sri MulyaniAfiliasi tidak diketahui1
Titis Budi WidowatiAfiliasi tidak diketahui1
Purnomo HadiAfiliasi tidak diketahui1
Abdul Rahman SiregarUniversitas Gadjah Mada1
Shinta HartantoUniversitas Gadjah Mada1
Sofia MubarikaUniversitas Gadjah Mada1
Camelia HerdiniUniversitas Gadjah Mada1
Bambang HariwiyantoUniversitas Gadjah Mada1
Akira HosoyamaNational Institute of Technology and Evaluation1
Atsushi YamazoeNational Institute of Technology and Evaluation1
Hideaki NojiriThe University of Tokyo1
M. MurwantokoAfiliasi tidak diketahui1
Ch. Retna HandayaniAfiliasi tidak diketahui1
T. TrijokoUniversitas Gadjah Mada1
Aushia Tanzih Al HaqUniversitas Gadjah Mada1
Endah Sri PalupiJenderal Soedirman University1
PUDJI ASTUTIAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ugm.ac.id/jtbb/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">The Effect of Ethanolic Extract of Cashew Fruit Peel on The Liver Histological Structure in Rat (Rattus norvegicus Berkenhout, 1769)</dc:title>
	<dc:creator>Zusrina, Laili Mufli</dc:creator>
	<dc:creator>Retnoaji, Bambang</dc:creator>
	<dc:creator>Wijayanti, Nastiti</dc:creator>
	<dc:subject xml:lang="en-US">cashew fruit; peel; extract; mouse; liver; histology</dc:subject>
	<dc:description xml:lang="en-US">Cashew fruit peel is a waste produced from the cashew nut industry, and it has not been utilized optimally yet. Cashew peel extract has the potential to be used as a contraceptive agent, which capable of reducing reproductive capacity. However, its side effects on other tissue and organ such as liver not clearly studied yet. This study aims to determine the effect of ethanolic extracts of cashew peel on the histological structure of the white rat liver. In this study, 21 female white rats were used and be grouped for control (6 mice) which were treated with CMCMa 0.5% and 15 mice were treated with peel extract of 500 mg/kg body every day for one month. Liver for examination was collected sequentially at 3rd, 5th, 8th, 11th, and 14th of the estrous cycle. The liver was processed for histological observation and stained with Hematoxylin Eosin and Mallory Acid Fuchsin staining solution. The liver hepatocyte was observed for it abnormality and be scored to calculate the number of cell damage or abnormality. The result showed that peel extract-treated mouse liver was similar to control ones; we did not witness any evidence of fibrosis, pyknosis and cellular necrosis on either control or treated mouse. Statistical analysis by SPSS showed that the p-value between the control and treatment groups was 0.078 (&gt; 0.05) so there was no significant difference between control and treatment. It could be concluded that ethanolic extracts of cashew nuts peel with a concentration of 500 mg/kg body weight caused no effect on the mouse liver histological structure. application with reduced-dosages of NPK fertilizers were arranged in a random block design with three replicates. The results show that large quantities of silica bodies attached to the surface of EFB fibers and amounting to 0.44% soluble Si. The FFB data indicated that the application of 75% NPK + 500 kg composted EFB + 2 L BioSilAc/ha/year on a five-year-old plant resulted in higher yield than that obtained from 100% standard dosage of NPK. The study also revealed that the application of EFB compost reduced 50% of BioSilAc dosage.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Gadjah Mada</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2019-12-16</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US"></dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ugm.ac.id/jtbb/article/view/39275</dc:identifier>
	<dc:identifier>10.22146/jtbb.39275</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Tropical Biodiversity and Biotechnology; Vol 4, No 3 (2019): Desember; 113-118</dc:source>
	<dc:source>2540-9581</dc:source>
	<dc:source>2540-9573</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ugm.ac.id/jtbb/article/view/39275/26552</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2019 Journal of Tropical Biodiversity and Biotechnology</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</dc:rights>
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