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Ulva lactuca Linnaeus Potentially Promotes Reproductive Indices and Depressive-like Behavior of Hypertriglyceridemia Male Wistar Rats (Rattus norvegicus Berkenhout, 1769)

Journal of Tropical Biodiversity and Biotechnology · Vol. 5 No. 3 (2020) · hlm. 228–238

DOI
10.22146/jtbb.57924
ISSN
2540-9581, 2540-9573
Terbit
2020-12-14
Penerbit
Universitas Gadjah Mada
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Excessive consumption of fatty foods can lead to hyperlipidemia, which is often coupled with hypertriglyceridemia (HTG), a condition where blood plasma triglyceride (TG) levels elevated beyond normal levels. This condition may disturb physiological functions of the body, such as reproductive functions, and other physiological imbalances leading to chronic stress and depression. Ulva lactuca is a potential natural treatment for HTG, as it contains various nutrients to aid physiological functions. This seaweed also has high levels of Cd, which can increase depression. Therefore, research on the potential benefits of U. lactuca should be followed by an investigation of its health risks. This research aimed to examine the effects of HTG and treatment with U. lactuca on reproduction and depressive-like behavior of male Wistar rats (Rattus norvegicus Berkenhout, 1769). The data collected in this research include body weight, serum TG concentration, gonadosomatic index (GSI), serum testosterone concentration using competitive ELISA, and depressive-like behaviors assessed using the Forced Swim Test (FST) and Open Field Test (OFT). Data were analyzed using One-Way ANOVA followed by DMRT, independent- and paired-samples t-test, and Kruskal-Wallis H test with a significance value of α=0.05. Body weight, serum TG and testosterone concentration, GSI, and depressive-like behaviors were increased by the HTG condition. Ulva lactuca at the1500 mg/kg BW/day did not significantly affect body weight, testosterone concentration, and depressive-like behaviors of HTG rats. Meanwhile, this treatment significantly increased the GSI and depressive-like behaviors of healthy rats. These results suggest that Ulva lactuca treatment not only enhances gonad growth and development but also increases depressive-like behaviors.

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  • Universitas Gadjah Mada
  • National Research and Innovation Agency
  • Cenderawasih University
  • Ministry of Environment and Forestry, Republic of Indonesia
  • STKIP Modern Ngawi
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Rekan penulisOrganisasiArtikel bersama
Slamet WidiyantoUniversitas Gadjah Mada3
Muhammad Said RifqiUniversitas Gadjah Mada2
Mulyati MuyatiUniversitas Gadjah Mada1
Cut M. TirayaUniversitas Gadjah Mada1
Andreas S. BudiUniversitas Gadjah Mada1
Paul J. KawatuAfiliasi tidak diketahui1
Aditya Krishar KarimCenderawasih University1
Rury EprilurahmanUniversitas Gadjah Mada1
Lisa HandayaniUniversitas Gadjah Mada1
Annisa Lintang SariUniversitas Gadjah Mada1
Tri AtmokoMinistry of Environment and Forestry, Republic of Indonesia1
Bina Swasta SitepuNational Research and Innovation Agency1
Adristi Shafa WidyasariUniversitas Gadjah Mada1
Istiana PrihatiniNational Research and Innovation Agency1
MukhlisiNational Research and Innovation Agency1
Burhanuddin AdmanNational Research and Innovation Agency1
Ratna SusandariniUniversitas Gadjah Mada1
Rina ArifatiUniversitas Gadjah Mada1
Siiti SubandiyahUniversitas Gadjah Mada1
Anita YulianaUniversitas Gadjah Mada1
Aprilia RahmawatiSTKIP Modern Ngawi1
Isma Cahya Putri GunawanUniversitas Gadjah Mada1
Wilda Bunga Tina SanjayaUniversitas Gadjah Mada1
Maura Indria MeidianingUniversitas Gadjah Mada1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ugm.ac.id/jtbb/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Ulva lactuca Linnaeus Potentially Promotes Reproductive Indices and Depressive-like Behavior of Hypertriglyceridemia Male Wistar Rats (Rattus norvegicus Berkenhout, 1769)</dc:title>
	<dc:creator>Yulistiyanto, Anggoro Chandra</dc:creator>
	<dc:creator>Hersasanti, Mayumi</dc:creator>
	<dc:creator>Hartantyo, Rahadian Yudo</dc:creator>
	<dc:creator>Fitria, Laksmindra</dc:creator>
	<dc:creator>Chasani, Abdul Razaq</dc:creator>
	<dc:creator>Mulyati, Mulyati</dc:creator>
	<dc:subject xml:lang="en-US">Biology; Animal Physiology; Pharmacology</dc:subject>
	<dc:subject xml:lang="en-US">depression; hypertriglyceridemia; male reproduction; triglycerides; Ulva lactuca</dc:subject>
	<dc:description xml:lang="en-US">Excessive consumption of fatty foods can lead to hyperlipidemia, which is often coupled with hypertriglyceridemia (HTG), a condition where blood plasma triglyceride (TG) levels elevated beyond normal levels. This condition may disturb physiological functions of the body, such as reproductive functions, and other physiological imbalances leading to chronic stress and depression. Ulva lactuca is a potential natural treatment for HTG, as it contains various nutrients to aid physiological functions. This seaweed also has high levels of Cd, which can increase depression. Therefore, research on the potential benefits of U. lactuca should be followed by an investigation of its health risks. This research aimed to examine the effects of HTG and treatment with U. lactuca on reproduction and depressive-like behavior of male Wistar rats (Rattus norvegicus Berkenhout, 1769). The data collected in this research include body weight, serum TG concentration, gonadosomatic index (GSI), serum testosterone concentration using competitive ELISA, and depressive-like behaviors assessed using the Forced Swim Test (FST) and Open Field Test (OFT). Data were analyzed using One-Way ANOVA followed by DMRT, independent- and paired-samples t-test, and Kruskal-Wallis H test with a significance value of α=0.05. Body weight, serum TG and testosterone concentration, GSI, and depressive-like behaviors were increased by the HTG condition. Ulva lactuca at the1500 mg/kg BW/day did not significantly affect body weight, testosterone concentration, and depressive-like behaviors of HTG rats. Meanwhile, this treatment significantly increased the GSI and depressive-like behaviors of healthy rats. These results suggest that Ulva lactuca treatment not only enhances gonad growth and development but also increases depressive-like behaviors.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Gadjah Mada</dc:publisher>
	<dc:contributor xml:lang="en-US">Program Rekognisi Tugas Akhir 2020, Universitas Gadjah Mada</dc:contributor>
	<dc:contributor xml:lang="en-US">LPPT Universitas Gadjah Mada</dc:contributor>
	<dc:date>2020-12-14</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
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	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ugm.ac.id/jtbb/article/view/57924</dc:identifier>
	<dc:identifier>10.22146/jtbb.57924</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Tropical Biodiversity and Biotechnology; Vol 5, No 3 (2020): December; 228-238</dc:source>
	<dc:source>2540-9581</dc:source>
	<dc:source>2540-9573</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ugm.ac.id/jtbb/article/view/57924/30107</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/jtbb/article/downloadSuppFile/57924/12674</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/jtbb/article/downloadSuppFile/57924/12675</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/jtbb/article/downloadSuppFile/57924/12676</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/jtbb/article/downloadSuppFile/57924/12677</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/jtbb/article/downloadSuppFile/57924/12678</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/jtbb/article/downloadSuppFile/57924/12679</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/jtbb/article/downloadSuppFile/57924/13868</dc:relation>
	<dc:coverage xml:lang="en-US">Indonesia; South East Asia</dc:coverage>
	<dc:coverage xml:lang="en-US"></dc:coverage>
	<dc:coverage xml:lang="en-US"></dc:coverage>
	<dc:rights xml:lang="en-US">Copyright (c) 2020 Journal of Tropical Biodiversity and Biotechnology</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</dc:rights>
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