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Bioactivity and Metabolites Compounds of Medicinal Plants Endophytic Fungi in Indonesia

Journal of Tropical Biodiversity and Biotechnology · Vol. 9 No. 2 (2024)

DOI
10.22146/jtbb.79070
ISSN
2540-9581, 2540-9573
Terbit
2024-04-03
Penerbit
Universitas Gadjah Mada
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Indonesia is rich in diversity of medicinal plants, vital in traditional medicine and the pharmaceutical industry. However, overharvesting, along with population growth, land use changes, deforestation, and climate change, endanger these plants. This review investigates the potential of endophytic endosymbiont as an alternative. These endosymbionts can synthesise bioactive compounds similar to those found in medicinal plants. This study compiled data from various sources on endophytic fungi and their bioactivity. The review aims to categorise Indonesian medicinal plants, to identify their associated endophytic fungi from different plant parts, and to assess their bioactivity. The results revealed numerous medicinal plant families and a variety of endophytic fungi isolated from fruits, leaves, twigs, bark, roots, and rhizomes. These fungi exhibited bioactivities, including antioxidant, anticancer, antidiabetic, and antimicrobial effects, with metabolites such as alkaloids, flavonoids, peptides, phenols, polyketides, quinones, steroids, and terpenoids. Fusarium and Colletotrichum were the most common endophytic fungi found. Notably, the biological activity was consistent among endophytic fungi from various host organs, but variations were observed according to the host's geographical origin. This suggests that Indonesia's diverse geography influences metabolite production and activity. However, the same host plant may harbour different species in distinct organs. These findings indicate that endophytic fungi within medicinal plants represent a promising source of bioactive compounds for future Indonesian medicine production. Future research should explore metabolite compounds and bioactivity across different geographical regions.

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  • Hasanuddin University
  • Institut Teknologi Sepuluh Nopember
  • Rajamangala University of Technology
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Rekan penulisOrganisasiArtikel bersama
Seniwati DaliAfiliasi tidak diketahui11
Alfian NoorHasanuddin University6
Nunuk Hariani SoekamtoAfiliasi tidak diketahui6
Agus RiyadiAfiliasi tidak diketahui4
Muawanah MuawanahAfiliasi tidak diketahui4
Paulina TabaHasanuddin University4
Siti KhairunnurAfiliasi tidak diketahui4
Yusafir HalaAfiliasi tidak diketahui4
Maswati BaharuddinAfiliasi tidak diketahui4
Rugaiyah Andi ArfahAfiliasi tidak diketahui4
Muhammad LukmanAfiliasi tidak diketahui3
Rakhmad ArmusAfiliasi tidak diketahui3
Hanapi UsmanAfiliasi tidak diketahui3
Abdul Wahid WahabAfiliasi tidak diketahui3
Indah RayaAfiliasi tidak diketahui2
Sartika DanialAfiliasi tidak diketahui2
Umi KultsumAfiliasi tidak diketahui2
Mashuri MasriAfiliasi tidak diketahui2
Djabal Nur BasirHasanuddin University2
St FauziahAfiliasi tidak diketahui2
Syaharuddin KasimAfiliasi tidak diketahui2
Yamin ThweRajamangala University of Technology2
Yuri PamungkasInstitut Teknologi Sepuluh Nopember2
Myo Min AungAfiliasi tidak diketahui2
Firdaus FirdausAfiliasi tidak diketahui2
Nunuk Hariani SoekamtoAfiliasi tidak diketahui2
Muhammad ZakirHasanuddin University2
Sahidin SahidinAfiliasi tidak diketahui1
Idhul Ade Rikit FitraAfiliasi tidak diketahui1
DIKI KURNIAWANAfiliasi tidak diketahui1
Febi Adriana MutiaraAfiliasi tidak diketahui1
Mustari MustariAfiliasi tidak diketahui1
M Maulana Kurnia PratamaAfiliasi tidak diketahui1
Abdur Rahman ArifAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ugm.ac.id/jtbb/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Bioactivity and Metabolites Compounds of Medicinal Plants Endophytic Fungi in Indonesia</dc:title>
	<dc:creator>Sukmawaty, Eka</dc:creator>
	<dc:creator>Karim, Abdul</dc:creator>
	<dc:creator>dwyana, Zarsawaty</dc:creator>
	<dc:creator>Natsir, Hasnah</dc:creator>
	<dc:creator>Karim, Harningsih</dc:creator>
	<dc:creator>Ahmad, Ahyar</dc:creator>
	<dc:subject xml:lang="en-US">microbiology, biochemistry</dc:subject>
	<dc:subject xml:lang="en-US">Anticancer; Antimicrobe; Antioxidant; Endosymbiont microbes; Traditional medicine</dc:subject>
	<dc:description xml:lang="en-US">Indonesia is rich in diversity of medicinal plants, vital in traditional medicine and the pharmaceutical industry. However, overharvesting, along with population growth, land use changes, deforestation, and climate change, endanger these plants. This review investigates the potential of endophytic endosymbiont as an alternative. These endosymbionts can synthesise bioactive compounds similar to those found in medicinal plants.  This study compiled data from various sources on endophytic fungi and their bioactivity. The review aims to categorise Indonesian medicinal plants, to identify their associated endophytic fungi from different plant parts, and to assess their bioactivity. The results revealed numerous medicinal plant families and a variety of endophytic fungi isolated from fruits, leaves, twigs, bark, roots, and rhizomes. These fungi exhibited bioactivities, including antioxidant, anticancer, antidiabetic, and antimicrobial effects, with metabolites such as alkaloids, flavonoids, peptides, phenols, polyketides, quinones, steroids, and terpenoids. Fusarium and Colletotrichum were the most common endophytic fungi found. Notably, the biological activity was consistent among endophytic fungi from various host organs, but variations were observed according to the host's geographical origin. This suggests that Indonesia's diverse geography influences metabolite production and activity. However, the same host plant may harbour different species in distinct organs. These findings indicate that endophytic fungi within medicinal plants represent a promising source of bioactive compounds for future Indonesian medicine production. Future research should explore metabolite compounds and bioactivity across different geographical regions. </dc:description>
	<dc:publisher xml:lang="en-US">Universitas Gadjah Mada</dc:publisher>
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	<dc:date>2024-04-03</dc:date>
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	<dc:identifier>https://journal.ugm.ac.id/jtbb/article/view/79070</dc:identifier>
	<dc:identifier>10.22146/jtbb.79070</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Tropical Biodiversity and Biotechnology; Vol 9, No 2 (2024): June; jtbb79070</dc:source>
	<dc:source>2540-9581</dc:source>
	<dc:source>2540-9573</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ugm.ac.id/jtbb/article/view/79070/38898</dc:relation>
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	<dc:relation>https://journal.ugm.ac.id/jtbb/article/downloadSuppFile/79070/23836</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/jtbb/article/downloadSuppFile/79070/24836</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/jtbb/article/downloadSuppFile/79070/24946</dc:relation>
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	<dc:rights xml:lang="en-US">Copyright (c) 2024 Journal of Tropical Biodiversity and Biotechnology</dc:rights>
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