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Profiling of Single Garlic Extract Microencapsulation: Characterization, Antioxidant Activity, and Release Kinetic

Journal of Tropical Biodiversity and Biotechnology · Vol. 8 No. 3 (2023)

DOI
10.22146/jtbb.79072
ISSN
2540-9581, 2540-9573
Terbit
2023-11-23
Penerbit
Universitas Gadjah Mada
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0

Abstrak

Single garlic is known to have many benefits as an alternative therapy for various types of metabolic syndrome. The bioactive compounds, allicin and alliin, in garlic are unstable and easily degraded in digestion. Chitosan-alginate microencapsulation is thought to increase stability and protect active compound so its therapeutic effect is more optimal. This study aimed to characterize the microencapsulation chitosan-alginate of single garlic extract (MCA- SGE), as well as to examine the antioxidant activity and kinetic release of MCA-SGE in vitro. The research procedure includes the steps of single garlic extraction, preparation of MCA-SGE, characterization of MCA-SGE (PSA, SEM, and FTIR) as well as biological testing of MCA-SGE through antioxidant activity and kinetic release tests. PSA results showed the mean particle size of MCA-SGE was 439.0 ± 1.9 nm or 0.4 m with a polydispersity index (PDI) value of 0.579 ± 0.046 and a zeta potential value of 15.4 ± 0.3 mV. The SEM results showed that the morphology of MCA-SGE was spherical with a smooth surface and a micrometre size of 0.4 - 0.7 µm. The FTIR results describe a shift in absorption and addition of SGE functional groups after encapsulation. The results of the antioxidant activity test showed the antioxidant activity of MCA-SGE was 65%, while SGE was 55%. The results of the kinetic release showed that more allicin and alliin were released by SGE than MCA-SGE during the 4-hour kinetic release simulation. MCA-SGE has the potential to be used as a drug delivery system with controlled release.

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  • State University of Malang
  • State University of Medan
  • Universitas Muhammadiyah Gresik
  • University of Brawijaya
  • Institut Teknologi Sepuluh Nopember
  • National Nuclear Energy Agency of Indonesia
  • The University of Tokyo
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Rekan penulisOrganisasiArtikel bersama
Yuslinda AnnisaUniversity of Brawijaya7
Hendra SusantoState University of Malang6
Muhammad Sasmito DjatiUniversity of Brawijaya4
Hidajah RachmawatiUniversitas Muhammadiyah Malang4
R Bg. IrawantoNational Research and Innovation Agency4
Sutopo SutopoState University of Malang2
Agung WitjoroState University of Malang2
Abdul GofurState University of Malang2
Tsania Nur DiyanaState University of Malang1
Dayuni AgustinaState University of Medan1
Erra Fazira Fay SiregarState University of Medan1
Novita Pratiwi SilalahiState University of Medan1
Supriyono Koes HandayantoState University of Malang1
Muhammad Iqbal SamanState University of Malang1
Najib MohammedState University of Malang1
Yunita RakhmawatiState University of Malang1
Dwi Novri SupriatiningrumUniversitas Muhammadiyah Gresik1
Sutrisno Adi PrayitnoUniversitas Muhammadiyah Gresik1
Endah MulyaniUniversitas Muhammadiyah Gresik1
Eka Srirahayu AriestiningsihUniversitas Muhammadiyah Gresik1
Ahmad TaufiqState University of Malang1
Edy Giri Rachman PutraNational Nuclear Energy Agency of Indonesia1
Nurul HidayatState University of Malang1
Atsushi OkazawaThe University of Tokyo1
Isao WatanabeRIKEN1
Nobuhiko KojimaToyota Physical and Chemical Research Institute1
Suminar PratapaInstitut Teknologi Sepuluh Nopember1
Darminto DarmintoInstitut Teknologi Sepuluh Nopember1
Alfi TsurayaUniversity of Brawijaya1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jurnal.ugm.ac.id/jtbb/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Profiling of Single Garlic Extract Microencapsulation: Characterization, Antioxidant Activity, and Release Kinetic</dc:title>
	<dc:creator>Lestari, Sri Rahayu</dc:creator>
	<dc:creator>Ghofur, Abdul</dc:creator>
	<dc:creator>Maslikah, Siti Imroatul</dc:creator>
	<dc:creator>Sunaryono, Sunaryono</dc:creator>
	<dc:creator>Rahma, Amalia Nur</dc:creator>
	<dc:creator>Aisyah, Dahniar Nur</dc:creator>
	<dc:creator>Mufidah, Ikfi Nihayatul</dc:creator>
	<dc:creator>Rifqi, Nadiya Dini</dc:creator>
	<dc:creator>Prastita, Nenes</dc:creator>
	<dc:creator>Miasih, Dewi Sekar</dc:creator>
	<dc:creator>Baroroh, Alif Rosyidah El</dc:creator>
	<dc:subject xml:lang="en-US">Biology</dc:subject>
	<dc:subject xml:lang="en-US">Microencapsulation, Chitosan-alginate, Single garlic extract</dc:subject>
	<dc:description xml:lang="en-US">Single garlic is known to have many benefits as an alternative therapy for various types of metabolic syndrome. The bioactive compounds, allicin and alliin, in garlic are unstable and easily degraded in digestion. Chitosan-alginate microencapsulation is thought to increase stability and protect active compound so its therapeutic effect is more optimal. This study aimed to characterize the microencapsulation chitosan-alginate of single garlic extract (MCA- SGE), as well as to examine the antioxidant activity and kinetic release of MCA-SGE in vitro. The research procedure includes the steps of single garlic extraction, preparation of MCA-SGE, characterization of MCA-SGE (PSA, SEM, and FTIR) as well as biological testing of MCA-SGE through antioxidant activity and kinetic release tests. PSA results showed the mean particle size of MCA-SGE was 439.0 ± 1.9 nm or 0.4 m with a polydispersity index (PDI) value of 0.579 ± 0.046 and a zeta potential value of 15.4 ± 0.3 mV. The SEM results showed that the morphology of MCA-SGE was spherical with a smooth surface and a micrometre size of 0.4 - 0.7 µm. The FTIR results describe a shift in absorption and addition of SGE functional groups after encapsulation. The results of the antioxidant activity test showed the antioxidant activity of MCA-SGE was 65%, while SGE was 55%. The results of the kinetic release showed that more allicin and alliin were released by SGE than MCA-SGE during the 4-hour kinetic release simulation. MCA-SGE has the potential to be used as a drug delivery system with controlled release.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Gadjah Mada</dc:publisher>
	<dc:contributor xml:lang="en-US">Directorate of Research, Technology, and Community Service, The Ministry of Education, Culture, Research, and Technology Republic Indonesia</dc:contributor>
	<dc:date>2023-11-23</dc:date>
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	<dc:identifier>https://journal.ugm.ac.id/jtbb/article/view/79072</dc:identifier>
	<dc:identifier>10.22146/jtbb.79072</dc:identifier>
	<dc:source xml:lang="en-US">Journal of Tropical Biodiversity and Biotechnology; Vol 8, No 3 (2023): December; jtbb79072</dc:source>
	<dc:source>2540-9581</dc:source>
	<dc:source>2540-9573</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ugm.ac.id/jtbb/article/view/79072/37886</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/jtbb/article/downloadSuppFile/79072/23831</dc:relation>
	<dc:relation>https://journal.ugm.ac.id/jtbb/article/downloadSuppFile/79072/23832</dc:relation>
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	<dc:coverage xml:lang="en-US"></dc:coverage>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Journal of Tropical Biodiversity and Biotechnology</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-sa/4.0</dc:rights>
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