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Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L.

Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences · Vol. 5 No. 2 (2015) · hlm. 88–91

DOI
10.11594/jtls.05.02.06
ISSN
2527-4376, 2087-5517
Terbit
2015-06-29
Penerbit
Journal of Tropical Life Science
Bahasa
eng

Abstrak

Hedyotis corymbosa, with local name rumput mutiara, is an anti-inflammatory, anti-cancer and hepatoprotective traditional medicine. The ethanol extract of H. corymbosa L. shows inhibitory activity to human YMB-1 breast cancer cell line with an IC50 of 6.51 mg/ml. The methylene chloride fraction shows a potential cytotoxic activity with an IC50 of 2.75 mg/ml. To obtain a lead compound, the extract was further purified by column chromatography. A pure compound is obtained which shows inhibitory activities against YMB-1, HL60 and KB human cell lines with IC50 values of 0.7; 11.0 and 104.2 mg/ml, respectively. Based on the 1D and 2D FT-NMR data, the isolated compound is an asperuloside.

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40 penulis · 141 tautan kepenulisan bersama · 67 lintas organisasi · menampilkan 40 yang paling banyak terhubung

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  • Indonesian Institute of Sciences
  • Padjadjaran University
  • Universitas Gadjah Mada
  • National Research and Innovation Agency
  • Osaka City University
  • Universitas Muhammadiyah Prof Dr Hamka
  • Universitas Jenderal Achmad Yani
  • Organisasi lain
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Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Sri HandayaniIndonesian Institute of Sciences3
Unang SupratmanPadjadjaran University2
Rani MaharaniPadjadjaran University2
Kindi FarabiPadjadjaran University2
Nurlelasari NurlelasariPadjadjaran University2
Darwati DarwatiPadjadjaran University2
Tri MayantiPadjadjaran University2
Rizna Triana DewiIndonesian Institute of Sciences2
Faiza MaryaniIndonesian Institute of Sciences2
Indah Dwiatmi DewijantiIndonesian Institute of Sciences2
Lia MeilawatiIndonesian Institute of Sciences2
Euis FilailaIndonesian Institute of Sciences2
Gian PrimahanaNational Research and Innovation Agency2
Rosmalena RosmalenaAtma Jaya Catholic University of Indonesia2
Vivitri Dewi PrasastyAtma Jaya Catholic University of Indonesia2
Edy MeiyantoUniversitas Gadjah Mada1
Ratna Asmah SusidartiUniversitas Gadjah Mada1
Akhmad DarmawanIndonesian Institute of Sciences1
Riris Istighfari JenieUniversitas Gadjah Mada1
Berna ElyaUniversity of Indonesia1
KusmardiAfiliasi tidak diketahui1
Siti Saudah RohmatUniversitas Muhammadiyah Prof Dr Hamka1
Vera LadeskaUniversitas Muhammadiyah Prof Dr Hamka1
Zalinar UdinIndonesian Institute of Sciences1
Chandra RisdianIndonesian Institute of Sciences1
Desak Gede Sri AndayaniIndonesian Institute of Sciences1
Rahmaniar MulyaniPadjadjaran University1
Anny SulaswatyIndonesian Institute of Sciences1
Nur QaanitaatiUniversitas Jenderal Achmad Yani1
Desak Gede Tirta AndiniUniversitas Airlangga1
Eva NursyifaUniversitas Jenderal Achmad Yani1
Rina Hidayati PratiwiUniversitas Indraprasta PGRI1

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Sumber metadata: OAI-PMH (metadata jurnal) http://jtrolis.ub.ac.id/index.php/jtrolis/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L.</dc:title>
	<dc:creator xml:lang="en">Artanti, Nina</dc:creator>
	<dc:creator xml:lang="en">Hanafi, Muhammad</dc:creator>
	<dc:creator xml:lang="en">Andriyani, Rina</dc:creator>
	<dc:creator xml:lang="en">Saraswaty, Vienna</dc:creator>
	<dc:creator xml:lang="en">Udin, Linar Zalinar</dc:creator>
	<dc:creator xml:lang="en">Lotulung, Puspa D</dc:creator>
	<dc:creator xml:lang="en">Fujita, Ken Ichi</dc:creator>
	<dc:creator xml:lang="en">Usuki, Yoshinosuke</dc:creator>
	<dc:description xml:lang="en">Hedyotis corymbosa, with local name rumput mutiara, is an anti-inflammatory, anti-cancer and hepatoprotective traditional medicine.  The ethanol extract of H. corymbosa L. shows inhibitory activity to human YMB-1 breast cancer cell line with an IC50 of 6.51 mg/ml.  The methylene chloride fraction shows a potential cytotoxic activity with an IC50 of 2.75 mg/ml.  To obtain a lead compound, the extract was further purified by column chromatography. A pure compound is obtained which shows inhibitory activities against YMB-1, HL60 and KB human cell lines with IC50 values of 0.7; 11.0 and 104.2 mg/ml, respectively.  Based on the 1D and 2D FT-NMR data, the isolated compound is an asperuloside.</dc:description>
	<dc:publisher xml:lang="en">Journal of Tropical Life Science</dc:publisher>
	<dc:date>2015-06-29</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/283</dc:identifier>
	<dc:identifier>10.11594/jtls.05.02.06</dc:identifier>
	<dc:source xml:lang="en">Journal of Tropical Life Science; Vol. 5 No. 2 (2015); 88-91</dc:source>
	<dc:source>2527-4376</dc:source>
	<dc:source>2087-5517</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/283/pdf_11</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2015 Journal of Tropical Life Science</dc:rights>
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