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Apigenin, an Anticancer Isolated from Macaranga gigantifolia Leaves

Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences · Vol. 6 No. 1 (2016) · hlm. 7–9

DOI
10.11594/jtls.06.01.02
ISSN
2527-4376, 2087-5517
Terbit
2016-03-04
Penerbit
Journal of Tropical Life Science
Bahasa
eng

Abstrak

Apigenin, a flavonoid compound has been isolated from the ethyl acetate fraction of methanol extract of Macaranga gigantifolia leaves. Isolation and purification of apigenin conducted using chromatographic method, and chemical structure characterized based on spectroscopic data. In vitro anticancer activity test against murine leukemia P-388 cell line showed potential activity with IC50 14.13 μg/mL.Key words: apigenin, flavones, Macaranga gigantifolia, anticancer, murine leukemia P-388 cell line.

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  • Padjadjaran University
  • Indonesian Institute of Sciences
  • National Research and Innovation Agency
  • Jenderal Soedirman University
  • Institut Teknologi Indonesia
  • Mulawarman University
  • Universitas Halu Oleo
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Rekan penulisOrganisasiArtikel bersama
Unang SupratmanPadjadjaran University12
Tri MayantiPadjadjaran University7
Al Arofatus NainiPadjadjaran University7
Kindi FarabiPadjadjaran University6
Yoshihito ShionoYamagata University6
Nurlelasari NurlelasariPadjadjaran University6
Desi HarnetiPadjadjaran University5
Ace Tatang HidayatPadjadjaran University5
Erina HilmayantiPadjadjaran University4
Dewa Gede KatjaSam Ratulangi University4
Mohamad Nurul AzmiUniversiti Sains Malaysia4
Gian PrimahanaNational Research and Innovation Agency4
Tjandrawati MozefIndonesian Institute of Sciences3
Ricson P. HutagaolUniversitas Nusa Bangsa3
Rani MaharaniPadjadjaran University3
Darwati DarwatiPadjadjaran University2
Harizon HarizonUniversitas Jambi2
Ferry Ferdiansyah SofianPadjadjaran University2
RehanaJenderal Soedirman University1
Eka Prasasti Nur RachmaniJenderal Soedirman University1
Puji LestariJenderal Soedirman University1
Wahyu SafriansyahPadjadjaran University1
Hadi KuncoroMulawarman University1
Indah Dwiatmi DewijantiIndonesian Institute of Sciences1
Marissa AngelinaIndonesian Institute of Sciences1
Sofna Dewita Sari BanjarnahorAfiliasi tidak diketahui1
Muhammad NurdinUniversitas Halu Oleo1
MAULIDIYAH -Afiliasi tidak diketahui1
Megawati .Afiliasi tidak diketahui1
SukirnoAfiliasi tidak diketahui1
Medi HendraMulawarman University1
Ahmad RandyNational Research and Innovation Agency1
Novita ArianiNational Research and Innovation Agency1
Sitti AisyaUniversitas Halu Oleo1
Marcelinus ChristwardanaInstitut Teknologi Indonesia1
Enjarlis EnjarlisInstitut Teknologi Indonesia1
Sri HandayaniInstitut Teknologi Indonesia1

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Sumber metadata: OAI-PMH (metadata jurnal) http://jtrolis.ub.ac.id/index.php/jtrolis/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Apigenin, an Anticancer Isolated from Macaranga gigantifolia Leaves</dc:title>
	<dc:creator xml:lang="en">Fajriah, Sofa</dc:creator>
	<dc:creator xml:lang="en">Megawati, Megawati</dc:creator>
	<dc:creator xml:lang="en">Darmawan, Akhmad</dc:creator>
	<dc:description xml:lang="en">Apigenin, a flavonoid compound has been isolated from the ethyl acetate fraction of methanol extract of Macaranga gigantifolia leaves. Isolation and purification of apigenin conducted using chromatographic method, and chemical structure characterized based on spectroscopic data. In vitro anticancer activity test against murine leukemia P-388 cell line showed potential activity with IC50 14.13 μg/mL.Key words: apigenin, flavones, Macaranga gigantifolia, anticancer, murine leukemia P-388 cell line.</dc:description>
	<dc:publisher xml:lang="en">Journal of Tropical Life Science</dc:publisher>
	<dc:date>2016-03-04</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/300</dc:identifier>
	<dc:identifier>10.11594/jtls.06.01.02</dc:identifier>
	<dc:source xml:lang="en">Journal of Tropical Life Science; Vol. 6 No. 1 (2016); 7-9</dc:source>
	<dc:source>2527-4376</dc:source>
	<dc:source>2087-5517</dc:source>
	<dc:source>10.11594/jtls.6.1</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/300/pdf</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2016 Journal of Tropical Life Science</dc:rights>
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