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Bioactivity of Antibacterial Compounds Produced by Endophytic Actinomycetes from Neesia altissima

Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences · Vol. 8 No. 1 (2018) · hlm. 37–42

DOI
10.11594/jtls.08.01.07
ISSN
2527-4376, 2087-5517
Terbit
2018-01-05
Penerbit
Journal of Tropical Life Science
Bahasa
eng

Abstrak

Identification of alternate bioactive compounds isolated from microbial endophytes from plants may lead to better solution against antibiotic resistance. Main objective of this research is to determine the bioactivity of antibacterial compounds produced by endophytic actinomycetes, which was isolated from stem bark of Neesia altissima Bl. at Halimun Salak Mount. Detection of bioactive compounds was assayed using Thin Layer Chromatography (TLC) by employing bioautography. Bioactivity was assayed using crude extract against five microorganisms using agar diffusion methods. Tetracycline was used as a positive control. The result of antibacterial activity from endophytic actinomycetes isolate revealed that the bioactive compounds were effective in inhibiting the growth of bacteria Bacillus cereus (1.25 mm), Salmonella typhimurium (5.75 mm), and Shigella flexneri (4.37 mm). Bioactivity of ethyl acetate extract from bioactive compounds of endophytic actinomycetes has an antibacterial activity against bacteria Bacillus cereus (13.00 mm) and Staphylococcus aureus (15.90 mm), at a concentration of 250,000 ppm. Each of TLC fraction was able to inhibit growth of B. cereus at a minimum concentration of 10,000 ppm. In conclusion, the bioactive compounds produced by endophytic actinomycetes can have inhibitory effect towards B. cereus. The category of that compounds are narrow spectrum. The bioactive compound isolated from endophytic actinomycetes may have other implications such as anticancer, antifungal, and antioxidant.

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21 penulis · 70 tautan kepenulisan bersama · 25 lintas organisasi

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  • Indonesian Institute of Sciences
  • Universitas Indraprasta PGRI
  • Osaka City University
  • University of Indonesia
  • National Research and Innovation Agency
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
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Rekan penulisOrganisasiArtikel bersama
Linar Zalinar UdinIndonesian Institute of Sciences2
Muhammad HanafiNational Research and Innovation Agency2
Endang SulistyaniningsihUniversitas Indraprasta PGRI1
Jumadi JepriUniversitas Indraprasta PGRI1
Sri HandayaniIndonesian Institute of Sciences1
Rizna Triana DewiIndonesian Institute of Sciences1
Faiza MaryaniIndonesian Institute of Sciences1
Indah Dwiatmi DewijantiIndonesian Institute of Sciences1
Lia MeilawatiIndonesian Institute of Sciences1
Euis FilailaIndonesian Institute of Sciences1
Puspa Dewi LotulungIndonesian Institute of Sciences1
Rina AndriyaniIndonesian Institute of Sciences1
Vienna SaraswatyIndonesian Institute of Sciences1
Ken Ichi FujitaOsaka City University1
Yoshinosuke UsukiOsaka City University1
Lestari Elvina WibowoUniversity of Indonesia1
Sumi HUDIYONOUniversity of Indonesia1

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Sumber metadata: OAI-PMH (metadata jurnal) http://jtrolis.ub.ac.id/index.php/jtrolis/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Bioactivity of Antibacterial Compounds Produced by Endophytic Actinomycetes  from Neesia altissima</dc:title>
	<dc:creator xml:lang="en">Pratiwi, Rina Hidayati</dc:creator>
	<dc:creator xml:lang="en">Hanafi, Muhammad</dc:creator>
	<dc:creator xml:lang="en">Artanti, Nina</dc:creator>
	<dc:creator xml:lang="en">Pratiwi, Rosa Dewi</dc:creator>
	<dc:subject xml:lang="en">Bioactivity</dc:subject>
	<dc:subject xml:lang="en">bioactive compounds</dc:subject>
	<dc:subject xml:lang="en">effectivity</dc:subject>
	<dc:subject xml:lang="en">Neesia altissima Bl.</dc:subject>
	<dc:subject xml:lang="en">Streptomyces sp.</dc:subject>
	<dc:description xml:lang="en">Identification of alternate bioactive compounds isolated from microbial endophytes from plants may lead to better solution against antibiotic resistance. Main objective of this research is to determine the bioactivity of antibacterial compounds produced by endophytic actinomycetes, which was isolated from stem bark of Neesia altissima Bl. at Halimun Salak Mount. Detection of bioactive compounds was assayed using Thin Layer Chromatography (TLC) by employing bioautography. Bioactivity was assayed using crude extract against five microorganisms using agar diffusion methods. Tetracycline was used as a positive control. The result of antibacterial activity from endophytic actinomycetes isolate revealed that the bioactive compounds were effective in inhibiting the growth of bacteria Bacillus cereus (1.25 mm), Salmonella typhimurium (5.75 mm), and Shigella flexneri (4.37 mm). Bioactivity of ethyl acetate extract from bioactive compounds of endophytic actinomycetes has an antibacterial activity against bacteria Bacillus cereus (13.00 mm) and Staphylococcus aureus (15.90 mm), at a concentration of 250,000 ppm. Each of TLC fraction was able to inhibit growth of B. cereus at a minimum concentration of 10,000 ppm. In conclusion, the bioactive compounds produced by endophytic actinomycetes can have inhibitory effect towards B. cereus. The category of that compounds are narrow spectrum. The bioactive compound isolated from endophytic actinomycetes may have other implications such as anticancer, antifungal, and antioxidant.</dc:description>
	<dc:publisher xml:lang="en">Journal of Tropical Life Science</dc:publisher>
	<dc:date>2018-01-05</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/872</dc:identifier>
	<dc:identifier>10.11594/jtls.08.01.07</dc:identifier>
	<dc:source xml:lang="en">Journal of Tropical Life Science; Vol. 8 No. 1 (2018); 37 - 42</dc:source>
	<dc:source>2527-4376</dc:source>
	<dc:source>2087-5517</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/872/pdf</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2018 Journal of Tropical Life Science</dc:rights>
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