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The Role of Black Soybean and Purple Sweet Potato Active Compound on Advanced Glycation End-Product in Streptozotocin-Induced Type 2 Diabetes Mellitus Rat

Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences · Vol. 9 No. 2 (2019) · hlm. 139–145

DOI
10.11594/jtls.09.02.02
ISSN
2527-4376, 2087-5517
Terbit
2019-05-24
Penerbit
Journal of Tropical Life Science
Bahasa
eng

Abstrak

Diabetic nephropathy is one of the diabetes complications attacking kidney leading to kidney damage. Hyperglycemia accompanying DM causes the increase of Ad-vanced Glycation End-Product (AGE) and Receptor Advanced Glycation End-Product (RAGE) activity, then develop kidney damage and other diabetes compli-cations. The study aimed to investigate the effect of black soybean, purple sweet potato, or their combination on the expression of AGE, RAGE, and kidney necro-sis T2DM model rats. The rats were given with high-calorie diet for five weeks and then injected with a low dose of streptozotocin (30 m/kg Body Weight) in intraperitoneal. DM rats were divided into: normal, K- (T2DM), K+ (T2DM + glibenclamide 0.6 mg/kg body weight), P1 (T2DM + black soybean), P2 (T2DM + purple sweet potato), and P3-5 Combination 1-3 (T2DM + combination of black soybean and purple sweet potato in ratio of 1: 3, 2: 2, and 3: 1). DM rats were then given the treatments for thirty days. The effect of black soybean, purple sweet potato, or the combination of both was evaluated through the expression of AGE, RAGE, and necrosis of renal tubules. The changes in renal tubules histological characteristics were evaluated using hematoxylin-eosin (HE) staining. Immuno-histochemistry analysis of renal tubules was to evaluate AGE-RAGE expression after the treatments. The research results indicated that there was a significant dif-ference from the combination of black soybean and purple sweet potato in reduc-ing AGE, RAGE, and renal tubules necrosis. The BSB and PSP combination ratio of 1:1 was able to improve renal tubules, decrease the expression of AGE and RAGE towards near normal. The combination of black soybean and purple sweet potato could be used as one of the alternatives to improve kidney damage in dia-betic nephropathy.

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  • State University of Malang
  • University of Brawijaya
  • Universitas Islam Negeri Palangka Raya
  • Universitas Kanjuruhan
  • Universitas PGRI Madiun
  • University of Technology Malaysia
  • University of Malaya
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Rekan penulisOrganisasiArtikel bersama
Hendra SusantoState University of Malang4
Dewi Sekar MiasihState University of Malang4
Alif Rosyidah El BarorohState University of Malang4
Sunaryono SunaryonoState University of Malang3
Herawati SusiloState University of Malang2
Muhammad Sasmito DjatiUniversity of Brawijaya2
Hidajah RachmawatiUniversitas Muhammadiyah Malang2
R Bg. IrawantoNational Research and Innovation Agency2
Siti ZubaidahState University of Malang2
Soeyati PoejianiUniversity of Brawijaya2
Noor HujjatusnainiUniversitas Islam Negeri Palangka Raya1
Aloysius Duran CorebimaUniversitas Kanjuruhan1
Sumarno Retro PrawiroUniversity of Brawijaya1
Wachidatul Linda YuhannaUniversitas PGRI Madiun1
Mimien Henie Irawati Al MuhdharState University of Malang1
Zainudin HassanUniversity of Technology Malaysia1
Najib MohammedState University of Malang1
Yunita RakhmawatiState University of Malang1
Sueb SuebState University of Malang1
Muhammad Mifta FausanState University of Malang1
Farrah Dina YusopUniversity of Malaya1
Sri Endah IndriwatiState University of Malang1
Dewi MurniAfiliasi tidak diketahui1
Paidi PaidiYogyakarta State University1
Umie LestariState University of Malang1
Rizkia SuciatiState University of Malang1
Susriyati MahanalState University of Malang1
Asham Bin JamaluddinState University of Makassar1
Dina MaulinaLampung University1
Sutiman Bambang SumitroUniversity of Brawijaya1
Dominikus Djago DjoaUniversitas Flores1
Nugrahaningsih NugrahaningsihState University of Semarang1
Betty LukiatiState University of Malang1
Abdul GhofurState University of Medan1

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Sumber metadata: OAI-PMH (metadata jurnal) http://jtrolis.ub.ac.id/index.php/jtrolis/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">The Role of Black Soybean and Purple Sweet Potato Active Compound on  Advanced Glycation End-Product in Streptozotocin-Induced Type 2 Diabetes Mellitus Rat</dc:title>
	<dc:creator xml:lang="en">Gofur, Abdul</dc:creator>
	<dc:creator xml:lang="en">Arifah, Siti Nur</dc:creator>
	<dc:creator xml:lang="en">Annisa, Yuslinda</dc:creator>
	<dc:creator xml:lang="en">Witjoro, Agung</dc:creator>
	<dc:creator xml:lang="en">Atho'illah, Mochammad Fitri</dc:creator>
	<dc:creator xml:lang="en">Lestari, Sri Rahayu</dc:creator>
	<dc:subject xml:lang="en">Black soybean</dc:subject>
	<dc:subject xml:lang="en">purple sweet potato</dc:subject>
	<dc:subject xml:lang="en">RAGE</dc:subject>
	<dc:subject xml:lang="en">AGE</dc:subject>
	<dc:subject xml:lang="en">renal tubules</dc:subject>
	<dc:subject xml:lang="en">T2DM</dc:subject>
	<dc:description xml:lang="en">Diabetic nephropathy is one of the diabetes complications attacking kidney leading to kidney damage. Hyperglycemia accompanying DM causes the increase of Ad-vanced Glycation End-Product (AGE) and Receptor Advanced Glycation End-Product (RAGE) activity, then develop kidney damage and other diabetes compli-cations. The study aimed to investigate the effect of black soybean, purple sweet potato, or their combination on the expression of AGE, RAGE, and kidney necro-sis T2DM model rats. The rats were given with high-calorie diet for five weeks and then injected with a low dose of streptozotocin (30 m/kg Body Weight) in intraperitoneal. DM rats were divided into: normal, K- (T2DM), K+ (T2DM + glibenclamide 0.6 mg/kg body weight), P1 (T2DM + black soybean), P2 (T2DM + purple sweet potato), and P3-5 Combination 1-3 (T2DM + combination of black soybean and purple sweet potato in ratio of 1 : 3, 2 : 2, and 3 : 1). DM rats were then given the treatments for thirty days. The effect of black soybean, purple sweet potato, or the combination of both was evaluated through the expression of AGE, RAGE, and necrosis of renal tubules. The changes in renal tubules histological characteristics were evaluated using hematoxylin-eosin (HE) staining. Immuno-histochemistry analysis of renal tubules was to evaluate AGE-RAGE expression after the treatments. The research results indicated that there was a significant dif-ference from the combination of black soybean and purple sweet potato in reduc-ing AGE, RAGE, and renal tubules necrosis. The BSB and PSP combination ratio of 1:1 was able to improve renal tubules, decrease the expression of AGE and RAGE towards near normal. The combination of black soybean and purple sweet potato could be used as one of the alternatives to improve kidney damage in dia-betic nephropathy.</dc:description>
	<dc:publisher xml:lang="en">Journal of Tropical Life Science</dc:publisher>
	<dc:date>2019-05-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/1095</dc:identifier>
	<dc:identifier>10.11594/jtls.09.02.02</dc:identifier>
	<dc:source xml:lang="en">Journal of Tropical Life Science; Vol. 9 No. 2 (2019); 139 - 145</dc:source>
	<dc:source>2527-4376</dc:source>
	<dc:source>2087-5517</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/1095/pdf</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2019 Journal of Tropical Life Science</dc:rights>
</oai_dc:dc>