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Malondialdehyde (MDA) Ovary and Estradiol Blood Serum Levels of Premenopause White Rat (Rattus norvegicus) after Turmeric Powder (Curcuma longa L.) Treatment

Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences · Vol. 9 No. 3 (2019) · hlm. 237–242

ISSN
2527-4376, 2087-5517
Terbit
2019-10-26
Penerbit
Journal of Tropical Life Science
Bahasa
eng

Abstrak

Premenopause is a physiological condition in a female individual that has entered the aging period, a condition usually characterized by elevated MDA levels and decreased estrogen levels. The objective of this study was to determine the level of ovarian MDA and estradiol serum levels of premenopausal white rat blood after oral turmeric powder treatment. The animals used were 30 female Wistar strains white rat, age 12 months with an average body weight 200-250 g. The animals were divided into 6 groups, namely the negative control group (P0) with 4 ml/day distilled water treatment; positive control group (P1), this group was treated with pure curcumin powder 6.75 mg/kg BW; treatment group 1 (P2), group was treated with turmeric powder 100 mg/kg BW; treatment group 2 (P3); treatment group 3 (P4); and treatment group 4 (P5), these group were treated with turmeric powder at 200 mg/kg BW; 400 mg/kg BW; and 800 mg/kg BW dose respectively. Oral Treatment was administered daily for 27 days. Blood collection was performed on days 0, 14, and 28. The ovarian collection was conducted on day 28. MDA ovarian level was measured using TBA method and blood serum estradiol level was measured using ELISA method. The results exhibited that the positive control group (P1) and the treatment group (P2-P5) showed significantly lower ovarian MDA levels compared with the negative control group (P0). The turmeric powder dose 200 mg/kg BW (P3) can increase estradiol levels by day 14 (3.32 ± 0.26 ρg/mL) and at day 28 (4.01 ± 0.26 ρg/mL).

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  • Universitas Jember
  • Universitas Nahdlatul Ulama Lampung
  • Universitas Halu Oleo
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Rekan penulisOrganisasiArtikel bersama
Aris SoewondoUniversity of Brawijaya6
Nashi WidodoUniversity of Brawijaya4
Yudi YudiUniversitas Jambi4
Muhammad Sasmito DjatiUniversity of Brawijaya4
Fikriya Novita SariUniversity of Brawijaya4
Rahayu RahayuUniversitas Jambi3
Dheny WahyudhiUniversitas Jambi3
Yoga Dwi JatmikoUniversity of Brawijaya3
Moh DliyauddinUniversitas Jember3
Muhammad Halim NatsirUniversity of Brawijaya3
Sri WidyartiUniversity of Brawijaya3
Farida RachmawatiUniversity of Brawijaya3
Sefihara Paramitha SaktiUniversity of Brawijaya3
Luki AbdullahIPB University2
Asnath Maria FuahAfiliasi tidak diketahui2
Herry LiyusUniversitas Jambi2
Ahmad SoniAfiliasi tidak diketahui2
Sri RahayuUniversity of Brawijaya2
Dwi Purno WidekdoUniversity of Brawijaya2
Wayan Firdaus MahmudyUniversity of Brawijaya1
Achmad RidokUniversity of Brawijaya1
Cece SumantriIPB University1
Asep GunawanIPB University1
Ratna Sholatia HarahapIPB University1
Kasita ListyariniIPB University1
Salman YusufAfiliasi tidak diketahui1
Rachmat SomanjayaAfiliasi tidak diketahui1
Mohamad Agus SetiadiAfiliasi tidak diketahui1
Agung Prastyo NugrohoAfiliasi tidak diketahui1
Merryafinola IfaniAfiliasi tidak diketahui1
Suhartati SuhartatiAfiliasi tidak diketahui1
Anhar Faisal FananiUniversitas Nahdlatul Ulama Lampung1
Komang Gede WiryawanIPB University1
Salundik SalundikAfiliasi tidak diketahui1
La Ode Safiun ArihiUniversitas Halu Oleo1
Hikmawati HikmawatiAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://jtrolis.ub.ac.id/index.php/jtrolis/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Malondialdehyde (MDA) Ovary and Estradiol Blood Serum Levels of Premenopause White Rat (Rattus norvegicus) after Turmeric Powder (Curcuma longa L.) Treatment</dc:title>
	<dc:creator xml:lang="en">Suprihatin, Teguh</dc:creator>
	<dc:creator xml:lang="en">Widyarti, Sri</dc:creator>
	<dc:creator xml:lang="en">Rifa'i, Muhaimin</dc:creator>
	<dc:creator xml:lang="en">Rahayu, Sri</dc:creator>
	<dc:subject xml:lang="en">menopause</dc:subject>
	<dc:subject xml:lang="en">turmeric powder</dc:subject>
	<dc:subject xml:lang="en">curcumin</dc:subject>
	<dc:subject xml:lang="en">malondialdehyde</dc:subject>
	<dc:subject xml:lang="en">estradiol</dc:subject>
	<dc:description xml:lang="en">Premenopause is a physiological condition in a female individual that has entered the aging period, a condition usually characterized by elevated MDA levels and decreased estrogen levels. The objective of this study was to determine the level of ovarian MDA and estradiol serum levels of premenopausal white rat blood after oral turmeric powder treatment. The animals used were 30 female Wistar strains white rat, age 12 months with an average body weight 200-250 g. The animals were divided into 6 groups, namely the negative control group (P0) with 4 ml/day distilled water treatment; positive control group (P1), this group was treated with pure curcumin powder 6.75 mg/kg BW; treatment group 1 (P2), group was treated with turmeric powder 100 mg/kg BW; treatment group 2 (P3); treatment group 3 (P4); and treatment group 4 (P5), these group were treated with turmeric powder at 200 mg/kg BW; 400 mg/kg BW; and 800 mg/kg BW dose respectively. Oral Treatment was administered daily for 27 days. Blood collection was performed on days 0, 14, and 28. The ovarian collection was conducted on day 28. MDA ovarian level was measured using TBA method and blood serum estradiol level was measured using ELISA method. The results exhibited that the positive control group (P1) and the treatment group (P2-P5) showed significantly lower ovarian MDA levels compared with the negative control group (P0). The turmeric powder dose 200 mg/kg BW (P3) can increase estradiol levels by day 14 (3.32 ± 0.26 ρg/mL) and at day 28 (4.01 ± 0.26 ρg/mL).</dc:description>
	<dc:publisher xml:lang="en">Journal of Tropical Life Science</dc:publisher>
	<dc:date>2019-10-26</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/1148</dc:identifier>
	<dc:source xml:lang="en">Journal of Tropical Life Science; Vol. 9 No. 3 (2019); 237 - 242</dc:source>
	<dc:source>2527-4376</dc:source>
	<dc:source>2087-5517</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/1148/pdf</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2019 Journal of Tropical Life Science</dc:rights>
</oai_dc:dc>