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Anti-Apoptotic Activity of Anthocyanins has Potential to inhibit Caspase-3 Signaling

Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences · Vol. 10 No. 1 (2020) · hlm. 15–25

DOI
10.11594/jtls.10.01.03
ISSN
2527-4376, 2087-5517
Terbit
2020-01-31
Penerbit
Journal of Tropical Life Science
Bahasa
eng

Abstrak

Caspase-3 is a biochemical marker for cell apoptosis. Several studies focused on exploring caspase inhibitor potential in natural compounds. Hence, in this study investigated the anthocyanins as anti-apoptotic potential activity through caspase-3 using molecular docking. Six types of anthocyanin were retrieved from PubChem database and caspase-3 protein was downloaded from Protein Data Bank. Anthocyanins and caspase-3 protein were docked using HEX 8.0 program and visualized using Discovery Studio 4.1 software. The interaction among cyanidin-3-O-glucoside, delphinidin-3-O-glucoside, pelargonidin-3-O-glucoside, peonidin-3-O-glucoside and petunidin-3-O-glucoside showed similar binding pattern on caspase-3 protein. All of them bind to BIR2 region and allosteric site of caspase-3, which are a crucial site for apoptosis regulation. Interestingly, malvidin-3-O-glucoside also interacted with caspase-3 in BIR1, BIR2 and BIR3 regions. In addition, anthocyanins-caspase-3 complex showed low energy and demonstrated several hydrogen bonds, hydrophobic interactions and van der Waals interactions, which indicated stable interaction. This study implies that all anthocyanins have potential as inhibitor of caspase-3 protein and might have potential as anti-apoptosis. Further in-vitro and in-vivo studies are need to confirm this experimental.

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  • University of Brawijaya
  • Universitas Gadjah Mada
  • Universitas Ibrahimy
  • Suranaree University of Technology
  • Universitas Nusa Nipa Maumere
  • Universitas Mulia
  • Lambung Mangkurat University
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Rekan penulisOrganisasiArtikel bersama
Siti Mariyah UlfaUniversity of Brawijaya2
Yohanes BareUniversitas Nusa Nipa Maumere2
Sutrisno SutrisnoUniversity of Brawijaya1
Izaz Aqeiluz ZaharaUniversity of Brawijaya1
Heny YusufUniversitas Ibrahimy1
Laily SifaiyahUniversitas Ibrahimy1
Nur Dina CameliaUniversitas Ibrahimy1
Irfan MustafaUniversity of Brawijaya1
Nishia Waya MerayUniversitas Mulia1
Suharjono SuharjonoUniversity of Brawijaya1
Bambang SetiawanLambung Mangkurat University1
Takeshi OhtaJapan Tobacco (Japan)1
Vita AgustinaUniversity of Brawijaya1
Titin Andri WihastutiUniversity of Brawijaya1
Yoga Tribakti RachmadUniversity of Brawijaya1
Katsuhiro MiyajimaTokyo University of Agriculture1
Arie SrihardyastutieUniversity of Brawijaya1
Anna RoosdianaUniversity of Brawijaya1
Aulanni’am Aulanni’amUniversity of Brawijaya1
Eva Nur Laili OctavianaUniversity of Brawijaya1
Istiftakhun NikmahUniversity of Brawijaya1
Takashi OhtaKyoto University1
Mulyati MulyatiPREreview1
Rista Nikmatu RohmahUniversity of Brawijaya1
Damai Aulia NurmasariUniversity of Brawijaya1
Nuri MasruroUniversity of Brawijaya1
Lidwina Faraline TriprisilaUniversity of Brawijaya1
Takahisa YamadaNiigata University1
Eko SuyantoAfiliasi tidak diketahui1
Ardaning NurilianiUniversitas Gadjah Mada1
Widya WasityastutiUniversitas Gadjah Mada1
Wilda Bunga Tina SanjayaUniversitas Gadjah Mada1
Ulayatul KustiatiUniversity of Brawijaya1
Anisa Putri AvianaUniversitas Gadjah Mada1
Dinda AliffiaUniversitas Gadjah Mada1
Dewa Ayu Radha ParamitaUniversitas Gadjah Mada1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) http://jtrolis.ub.ac.id/index.php/jtrolis/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Anti-Apoptotic Activity of Anthocyanins has Potential to inhibit Caspase-3 Signaling</dc:title>
	<dc:creator xml:lang="en">Sari, Dewi Ratih Tirto</dc:creator>
	<dc:creator xml:lang="en">Safitri, Anna</dc:creator>
	<dc:creator xml:lang="en">Cairns, James Robert Ketudat</dc:creator>
	<dc:creator xml:lang="en">Fatchiyah, Fatchiyah</dc:creator>
	<dc:subject xml:lang="en">anthocyanins</dc:subject>
	<dc:subject xml:lang="en">apoptosis</dc:subject>
	<dc:subject xml:lang="en">caspase-3</dc:subject>
	<dc:subject xml:lang="en">in silico approach</dc:subject>
	<dc:description xml:lang="en">Caspase-3 is a biochemical marker for cell apoptosis. Several studies focused on exploring caspase inhibitor potential in natural compounds. Hence, in this study investigated the anthocyanins as anti-apoptotic potential activity through caspase-3 using molecular docking. Six types of anthocyanin were retrieved from PubChem database and caspase-3 protein was downloaded from Protein Data Bank. Anthocyanins and caspase-3 protein were docked using HEX 8.0 program and visualized using Discovery Studio 4.1 software. The interaction among cyanidin-3-O-glucoside, delphinidin-3-O-glucoside, pelargonidin-3-O-glucoside, peonidin-3-O-glucoside and petunidin-3-O-glucoside showed similar binding pattern on caspase-3 protein. All of them bind to BIR2 region and allosteric site of caspase-3, which are a crucial site for apoptosis regulation. Interestingly, malvidin-3-O-glucoside also interacted with caspase-3 in BIR1, BIR2 and BIR3 regions. In addition, anthocyanins-caspase-3 complex showed low energy and demonstrated several hydrogen bonds, hydrophobic interactions and van der Waals interactions, which indicated stable interaction. This study implies that all anthocyanins have potential as inhibitor of caspase-3 protein and might have potential as anti-apoptosis. Further in-vitro and in-vivo studies are need to confirm this experimental.</dc:description>
	<dc:publisher xml:lang="en">Journal of Tropical Life Science</dc:publisher>
	<dc:date>2020-01-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/1151</dc:identifier>
	<dc:identifier>10.11594/jtls.10.01.03</dc:identifier>
	<dc:source xml:lang="en">Journal of Tropical Life Science; Vol. 10 No. 1 (2020); 15 - 25</dc:source>
	<dc:source>2527-4376</dc:source>
	<dc:source>2087-5517</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/1151/pdf</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2020 Journal of Tropical Life Science</dc:rights>
</oai_dc:dc>