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Immunomodulatory Activity of Methanol Leaf Extract of Neem (Azadirachta indica Juss) Against Suppressor and Proinflammatory Molecules

Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences · Vol. 11 No. 3 (2021) · hlm. 309–315

DOI
10.11594/jtls.11.03.07
ISSN
2527-4376, 2087-5517
Terbit
2021-09-30
Penerbit
Journal of Tropical Life Science
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc/4.0

Abstrak

Neem plant is rich in bioactive constituents, which make it massively discussed the treatment of various diseases. A study on the immunomodulatory activities of neem is given here. This current work aimed to investigate the effects of neem leaf extract on immunocompetent cells. In vivo experiment was carried out using mice (Mus musculus) Â induced with DMBA, comprising positive control, negative control, and treatments of neem leaf extracts (250, 500, and 1000 ppm). Data obtained from flow cytometric analysis were evaluated using BD Cellquest ProTM software, then statistically analyzed in SPSS version 21. Parametric analysis in one-way ANOVA was performed at a significance level of 5%. The significant difference was compared in the Duncan test. The results showed that administration of neem leaf extracts significantly affected the expression of CD4+, CD8+, CD25+, CD62L, IL-10, and IL-17 cells.Neem leaf extract has immunomodulatory activities by increasing pressure molecules and decreasing pro-inflammatory molecules

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  • University of Brawijaya
  • Universitas Gadjah Mada
  • Universitas Muhammadiyah Malang
  • Southeast Asian Regional Centre for Tropical Biology
  • Universitas Jember
  • Nagoya University
  • Universitas Ibrahimy
  • Organisasi lain
  • Afiliasi tidak diketahui
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Rekan penulisOrganisasiArtikel bersama
Nashi WidodoUniversity of Brawijaya4
Aris SoewondoUniversity of Brawijaya4
Sri RahayuUniversity of Brawijaya3
Muhammad Sasmito DjatiUniversity of Brawijaya3
Fikriya Novita SariUniversity of Brawijaya3
Yoga Dwi JatmikoUniversity of Brawijaya3
Moh DliyauddinUniversitas Jember2
Muhammad Halim NatsirUniversity of Brawijaya2
Sri WidyartiUniversity of Brawijaya2
Sri RahayuUniversity of Brawijaya2
Farida RachmawatiUniversity of Brawijaya2
Sefihara Paramitha SaktiUniversity of Brawijaya2
Dwi Purno WidekdoUniversity of Brawijaya2
Wayan Firdaus MahmudyUniversity of Brawijaya1
Achmad RidokUniversity of Brawijaya1
Sofia Nur CahyaniUniversity of Brawijaya1
Belinda Nabiila Al FaizahUniversity of Brawijaya1
Rif’atul Hawani BurhanUniversity of Brawijaya1
Nabila Shafa Yumna SalsabilaUniversity of Brawijaya1
Noviana Dwi LestariUniversitas Muhammadiyah Malang1
Agung Pramana Warih MahendraUniversity of Brawijaya1
Hideo TsuboiNagoya University1
Inasanti Pandan WangiUniversitas Gadjah Mada1
Hary SulistyoUniversitas Gadjah Mada1
Chusnul HidayatUniversitas Gadjah Mada1
Siti Nur Aisyiah JamilUniversitas Ibrahimy1
Eva Ni’maturohmahUniversity of Brawijaya1
Widya Dwi Rukmi PutriUniversity of Brawijaya1
Firda Nuri AsyhariUniversity of Brawijaya1
Heni Sukma ZulfatimUniversity of Brawijaya1
Nenis Try Melani PutriUniversity of Brawijaya1
Ahmad Shobrun JamilUniversitas Muhammadiyah Malang1
Mansur IbrahimUniversitas Megarezky1
Haidar AzzamuddinAfiliasi tidak diketahui1
Sapti PuspitariniUniversitas Negeri Surabaya1
Maria UlinnuhaUniversity of Brawijaya1

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Sumber metadata: OAI-PMH (metadata jurnal) http://jtrolis.ub.ac.id/index.php/jtrolis/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Immunomodulatory Activity of Methanol Leaf Extract of Neem (Azadirachta indica Juss) Against Suppressor and Proinflammatory Molecules</dc:title>
	<dc:creator xml:lang="en">Supriyanto, Supriyanto</dc:creator>
	<dc:creator xml:lang="en">Widjanarko, Simon Bambang</dc:creator>
	<dc:creator xml:lang="en">Rifa'i, Muhaimin</dc:creator>
	<dc:creator xml:lang="en">Yunianta, Yunianta</dc:creator>
	<dc:subject xml:lang="en">Neem</dc:subject>
	<dc:subject xml:lang="en">immunocompetent cells</dc:subject>
	<dc:subject xml:lang="en">cytokine</dc:subject>
	<dc:subject xml:lang="en">immunomodulator</dc:subject>
	<dc:description xml:lang="en">Neem plant is rich in bioactive constituents, which make it massively discussed the treatment of various diseases. A study on the immunomodulatory activities of neem is given here. This current work aimed to investigate the effects of neem leaf extract on immunocompetent cells. In vivo experiment was carried out using mice (Mus musculus)  induced with DMBA, comprising positive control, negative control, and treatments of neem leaf extracts (250, 500, and 1000 ppm). Data obtained from flow cytometric analysis were evaluated using BD Cellquest ProTM software, then statistically analyzed in SPSS version 21. Parametric analysis in one-way ANOVA was performed at a significance level of 5%. The significant difference was compared in the Duncan test. The results showed that administration of neem leaf extracts significantly affected the expression of CD4+, CD8+, CD25+, CD62L, IL-10, and IL-17 cells .Neem leaf extract has immunomodulatory activities by increasing pressure molecules and decreasing pro-inflammatory molecules</dc:description>
	<dc:publisher xml:lang="en">Journal of Tropical Life Science</dc:publisher>
	<dc:date>2021-09-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/1780</dc:identifier>
	<dc:identifier>10.11594/jtls.11.03.07</dc:identifier>
	<dc:source xml:lang="en">Journal of Tropical Life Science; Vol. 11 No. 3 (2021); 309 - 315</dc:source>
	<dc:source>2527-4376</dc:source>
	<dc:source>2087-5517</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/1780/pdf</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2021 Journal of Tropical Life Science</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by-nc/4.0</dc:rights>
</oai_dc:dc>