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Potential of Single Garlic to Prevent Pro Inflammatory Macrophage and Inflammation in HFD Mice

Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences · Vol. 12 No. 1 (2022) · hlm. 101–106

DOI
10.11594/jtls.12.01.10
ISSN
2527-4376, 2087-5517
Terbit
2022-02-17
Penerbit
Journal of Tropical Life Science
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc/4.0

Abstrak

A high-fat-enriched diet causes an increase in the level of oxidized LDL (Ox-LDL) in the blood. The presence of Ox-LDL will activate macrophages to secrete pro-inflammatory cytokines and lead to severe inflammation. Single bulb garlic has a potential anti-inflammatory effect due to of high-fat diet. This research aimed to investigate the effect of single bulb garlic extract (SBGE) on the pro-inflammatory cytokines TNF-α (CD11b+TNF-α+) and IL-1b (CD11b+IL-1b+) in the spleen, spleen weight, and TNF-α secretion in HFD mice. Twenty-four mice were divided into six groups: normal (healthy mice); HFD (HFD mice without any treatment); HFD + Simvastatin (HFD mice receiving simvastatin); HFD + SBGE 100; HFD + SBGE 200; and HFD + SBGE 400 (HFD mice receiving 100, 200, and 400 mg/kg BW of SBGE for 4 weeks). Blood serum was collected at the end of treatment, and macrophage was isolated from the spleen. The relative number of CD11b+TNF-α+ and CD11b+IL-1b+ were examined using flow cytometry. SBGE treatment significantly (plt;0.05) reduced the spleen weight and the relative number of CD11b+TNF-α+ and CD11b+IL-1b+ in the spleen of HFD mice. SBGE treatment also prevents the elevation of TNF- α levels in the blood serum. The optimal dose of SBGE to diminish the relative number of CD11b+TNF-α+, CD11b+IL-1b+ in the spleen, and TNF-α in the serum was 100 mg/kg BW.

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  • State University of Malang
  • National Yang Ming Chiao Tung University
  • University of Indonesia
  • Universitas Halu Oleo
  • National Research and Innovation Agency
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Rekan penulisOrganisasiArtikel bersama
Siti ZubaidahState University of Malang6
Dewi Sekar MiasihAfiliasi tidak diketahui4
Yuslinda AnnisaAfiliasi tidak diketahui4
Susriyati MahanalState University of Malang4
Abdul GofurUniversity of Indonesia3
Muhammad Sasmito DjatiAfiliasi tidak diketahui3
Yunita RakhmawatiAfiliasi tidak diketahui3
Sunaryono SunaryonoState University of Malang3
Dina MaulinaAfiliasi tidak diketahui2
Agung WitjoroAfiliasi tidak diketahui2
Alif Rosyidah El BarorohAfiliasi tidak diketahui2
Hadi SuwonoState University of Malang2
Najib MohammedAfiliasi tidak diketahui2
Nik Ahmad Nizam Nik MalekAfiliasi tidak diketahui2
Rony IrawantoNational Research and Innovation Agency2
Hidajah RachmawatiAfiliasi tidak diketahui2
Alif Rosyidah El BarorohAfiliasi tidak diketahui2
Sri Endah IndriwatiState University of Malang2
Dewi MurniAfiliasi tidak diketahui2
Paidi PaidiAfiliasi tidak diketahui2
Siti Nur ArifahAfiliasi tidak diketahui2
Herawati SusiloState University of Malang1
Herwim Enggar PratiwiState University of Malang1
Sutiman B SumitroAfiliasi tidak diketahui1
Muhammad AminUniversitas Halu Oleo1
Mohamad AminAfiliasi tidak diketahui1
Muhammad KhalilAfiliasi tidak diketahui1
Fatchiyah FatchiyahAfiliasi tidak diketahui1
Ahmad RudijantoAfiliasi tidak diketahui1
Ahmad TaufiqAfiliasi tidak diketahui1
Moch SholehAfiliasi tidak diketahui1
Agustina Tri EndhartiAfiliasi tidak diketahui1
Sa’diyatul Rizqie Amaliyah FirdausAfiliasi tidak diketahui1
Adeodatus Yuda HandayaAfiliasi tidak diketahui1
Hardianto HardiantoAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://jtrolis.ub.ac.id/index.php/jtrolis/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Potential of Single Garlic to Prevent Pro Inflammatory Macrophage and Inflammation in HFD Mice</dc:title>
	<dc:creator xml:lang="en">Anggraini, Putri Diyah</dc:creator>
	<dc:creator xml:lang="en">Mufinadiroh, Miftahul</dc:creator>
	<dc:creator xml:lang="en">Susanto, Hendra</dc:creator>
	<dc:creator xml:lang="en">Lukiati, Betty</dc:creator>
	<dc:creator xml:lang="en">Lestari, Sri Rahayu</dc:creator>
	<dc:subject xml:lang="en">Single Bulb Garlic</dc:subject>
	<dc:subject xml:lang="en">HFD</dc:subject>
	<dc:subject xml:lang="en">macrophage</dc:subject>
	<dc:subject xml:lang="en">CD11b</dc:subject>
	<dc:subject xml:lang="en">TNF-α</dc:subject>
	<dc:subject xml:lang="en">IL-1b</dc:subject>
	<dc:subject xml:lang="en">spleen</dc:subject>
	<dc:description xml:lang="en">A high-fat-enriched diet causes an increase in the level of oxidized LDL (Ox-LDL) in the blood. The presence of Ox-LDL will activate macrophages to secrete pro-inflammatory cytokines and lead to severe inflammation. Single bulb garlic has a potential anti-inflammatory effect due to of high-fat diet. This research aimed to investigate the effect of single bulb garlic extract (SBGE) on the pro-inflammatory cytokines TNF-α (CD11b+TNF-α+) and IL-1b (CD11b+IL-1b+) in the spleen, spleen weight, and TNF-α secretion in HFD mice. Twenty-four mice were divided into six groups: normal (healthy mice); HFD (HFD mice without any treatment); HFD + Simvastatin (HFD mice receiving simvastatin); HFD + SBGE 100; HFD + SBGE 200; and HFD + SBGE 400 (HFD mice receiving 100, 200, and 400 mg/kg BW of SBGE for 4 weeks). Blood serum was collected at the end of treatment, and macrophage was isolated from the spleen. The relative number of CD11b+TNF-α+ and CD11b+IL-1b+ were examined using flow cytometry. SBGE treatment significantly (plt;0.05) reduced the spleen weight and the relative number of CD11b+TNF-α+ and CD11b+IL-1b+ in the spleen of HFD mice. SBGE treatment also prevents the elevation of TNF- α levels in the blood serum. The optimal dose of SBGE to diminish the relative number of CD11b+TNF-α+, CD11b+IL-1b+ in the spleen, and TNF-α in the serum was 100 mg/kg BW.</dc:description>
	<dc:publisher xml:lang="en">Journal of Tropical Life Science</dc:publisher>
	<dc:date>2022-02-17</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/1930</dc:identifier>
	<dc:identifier>10.11594/jtls.12.01.10</dc:identifier>
	<dc:source xml:lang="en">Journal of Tropical Life Science; Vol. 12 No. 1 (2022); 101-106</dc:source>
	<dc:source>2527-4376</dc:source>
	<dc:source>2087-5517</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/1930/568</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2022 Journal of Tropical Life Science</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by-nc/4.0</dc:rights>
</oai_dc:dc>