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Chemical Compounds and Antibacterial Activity of Thymus Vulgaris Leaves’ Ethanolic Extract Against Salmonella typhimurium: Thymus vulgaris Against Salmonella typhimurium

Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences · Vol. 14 No. 1 (2024) · hlm. 77–82

DOI
10.11594/jtls.14.01.09
ISSN
2527-4376, 2087-5517
Terbit
2024-02-09
Penerbit
Journal of Tropical Life Science
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc/4.0

Abstrak

Invasive non-typhoidal Salmonella is an important pathogen that causes life-threatening bloodstream infections. Antibiotic resistance in non-typhoidal Salmonella has emerged as a result of the increasing use of antibiotics; therefore, an alternative source of therapeutic agents is required. This study aimed to investigate the active compound and antibacterial activity of Thymus vulgaris leaves’ ethanolic extract against Salmonella typhimurium. Thin-layer chromatography was performed to identify the active compound in the ethanolic extract of T. vulgaris leaves. The antibiotic effect of the extract was carried out by agar dilution assay using the following concentrations: 0%, 2.5%, 5.0%, 7.5%, 10.0%, 12.5%, and 15.0% (w/v). Thymol and carvacrol were detected in the thin-layer chromatography. The minimum inhibitory concentration of the extract was 10.0% (w/v). In conclusion, T. vulgaris leaves’ ethanolic extract demonstrated antimicrobial activity against S. typhimurium. Further investigation is required to analyze the role of thymol and carvacrol as active compounds against S. typhimurium.

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30 penulis · 106 tautan kepenulisan bersama · 38 lintas organisasi

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  • University of Brawijaya
  • State University of Malang
  • Universitas Jember
  • University of Technology Malaysia
  • Rumah Sakit Umum Pusat Dr. Sardjito
  • Sam Ratulangi University
  • North Sumatra Islamic University
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
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Rekan penulisOrganisasiArtikel bersama
Amin AlnawajhaUniversity of Brawijaya5
Roihatul Muti'ahAfiliasi tidak diketahui2
Sunarto SantosoUniversity of Brawijaya2
Irawan SatriotomoAfiliasi tidak diketahui2
Hendra SusantoState University of Malang1
Ahmad TaufiqState University of Malang1
Moch SholehUniversity of Brawijaya1
Nik Ahmad Nizam Nik MalekUniversity of Technology Malaysia1
Sa’diyatul Rizqie Amaliyah FirdausUniversity of Brawijaya1
Adeodatus Yuda HandayaRumah Sakit Umum Pusat Dr. Sardjito1
Ira Resmi MelaniUniversity of Brawijaya1
Muhammad Farid WafiUniversity of Brawijaya1
Mohammad Reza RiandinataUniversity of Brawijaya1
Putri Aulawiya Rosyida HalimUniversity of Brawijaya1
Rizka Nurul HidayahUniversity of Brawijaya1
Belia Bima NafisaUniversity of Brawijaya1
Miftah Saiful ‘ArifinUniversity of Brawijaya1
Niniek BurhanAfiliasi tidak diketahui1
Erma SulistyaningsihUniversitas Jember1
Hidayat SujutiUniversity of Brawijaya1
Bagus HermansyahUniversitas Jember1
Loeki Enggar FitriUniversity of Brawijaya1
Didi CandradikusumaUniversity of Brawijaya1
Samsul ArifinAfiliasi tidak diketahui1
Josef S. B. TudaSam Ratulangi University1
Umar ZeinNorth Sumatra Islamic University1

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Sumber metadata: OAI-PMH (metadata jurnal) http://jtrolis.ub.ac.id/index.php/jtrolis/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Chemical Compounds and Antibacterial Activity of Thymus Vulgaris Leaves’ Ethanolic Extract Against Salmonella typhimurium: Thymus vulgaris Against Salmonella typhimurium</dc:title>
	<dc:creator xml:lang="en">Abousouh, Emad Khaleefah</dc:creator>
	<dc:creator xml:lang="en">Endharti, Agustina Tri</dc:creator>
	<dc:creator xml:lang="en">Santoso, Sanarto</dc:creator>
	<dc:creator xml:lang="en">Santosaningsih, Dewi</dc:creator>
	<dc:subject xml:lang="en">Antibacterial activity</dc:subject>
	<dc:subject xml:lang="en"> Carvacrol</dc:subject>
	<dc:subject xml:lang="en">Minimal inhibitory concentration</dc:subject>
	<dc:subject xml:lang="en"> Sal-monella</dc:subject>
	<dc:subject xml:lang="en"> Thymol</dc:subject>
	<dc:subject xml:lang="en"> Thymus vulgaris</dc:subject>
	<dc:description xml:lang="en">Invasive non-typhoidal Salmonella is an important pathogen that causes life-threatening bloodstream infections. Antibiotic resistance in non-typhoidal Salmonella has emerged as a result of the increasing use of antibiotics; therefore, an alternative source of therapeutic agents is required. This study aimed to investigate the active compound and antibacterial activity of Thymus vulgaris leaves’ ethanolic extract against Salmonella typhimurium. Thin-layer chromatography was performed to identify the active compound in the ethanolic extract of T. vulgaris leaves. The antibiotic effect of the extract was carried out by agar dilution assay using the following concentrations: 0%, 2.5%, 5.0%, 7.5%, 10.0%, 12.5%, and 15.0% (w/v). Thymol and carvacrol were detected in the thin-layer chromatography. The minimum inhibitory concentration of the extract was 10.0% (w/v). In conclusion, T. vulgaris leaves’ ethanolic extract demonstrated antimicrobial activity against S. typhimurium. Further investigation is required to analyze the role of thymol and carvacrol as active compounds against S. typhimurium.</dc:description>
	<dc:publisher xml:lang="en">Journal of Tropical Life Science</dc:publisher>
	<dc:date>2024-02-09</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/2939</dc:identifier>
	<dc:identifier>10.11594/jtls.14.01.09</dc:identifier>
	<dc:source xml:lang="en">Journal of Tropical Life Science; Vol. 14 No. 1 (2024); 77 – 82</dc:source>
	<dc:source>2527-4376</dc:source>
	<dc:source>2087-5517</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/2939/710</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Journal of Tropical Life Science</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by-nc/4.0</dc:rights>
</oai_dc:dc>