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Antioxidant Activity of Baby Java Citrus Peel Extract Promotes Lung Tissue Repair in Mice Challenged by Lipopolysaccharides: Antioxidant Activity of BJE Promotes Lung Tissue Repair

Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences · Vol. 14 No. 2 (2024) · hlm. 229–236

DOI
10.11594/jtls.14.02.03
ISSN
2527-4376, 2087-5517
Terbit
2024-05-31
Penerbit
Journal of Tropical Life Science
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc/4.0

Abstrak

Acute lung injury tends to be induced by infection or sepsis that disrupt alveolar and vascular permeability, neutrophil influx, and edema. Those impairments are worsened by the increase of oxidative stress along with hyperinflammation response. Oxidative stress in lung tissue could be indicated by malondialdehyde (MDA) and nuclear factor erythroid 2-related factor 2 (Nrf2) expression. This research aimed to evaluate the efficacy of Baby Java citrus peel extract (BJE) in suppressing oxidative stress and preventing lung injury in lipopolysaccharides (LPS)-induced mice. Twenty-five male BALB/c mice were divided into five groups consisting of untreated (N), LPS (A), and LPS-induced followed by treatment using BJE at various doses: 75 mg/kg BW (BJE-1), 105 mg/kg BW (BJE-2), and 150 mg/kg BW (BJE-3). Lungs were isolated for histopathological analysis also detection of MDA and Nrf2 using flow cytometry. BJE at the dose of 105 mg/kg BW could inhibit the alteration of lung histology following LPS challenge including alveolar and interstitial neutrophil infiltration, proteinaceous debris, and septal thickening. The same dose also showed good potency in suppressing MDA and Nrf2 levels as oxidative stress indicators. Our findings demonstrated protective effects of Baby Java citrus peel in acute lung injury and oxidative stress prevention after LPS exposure.

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  • University of Brawijaya
  • IPB University
  • Universitas Jambi
  • Universitas Jember
  • Universitas Nahdlatul Ulama Lampung
  • Universitas Halu Oleo
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Rekan penulisOrganisasiArtikel bersama
Sri RahayuUniversity of Brawijaya8
Yoga Dwi JatmikoUniversity of Brawijaya7
Sri WidyartiUniversity of Brawijaya7
Muhammad Halim NatsirUniversity of Brawijaya6
Muhammad Sasmito DjatiUniversity of Brawijaya5
Nashi WidodoUniversity of Brawijaya4
Yudi YudiUniversitas Jambi4
Sri WidyartiAfiliasi tidak diketahui4
Moh DliyauddinUniversitas Jember4
Rahayu RahayuUniversitas Jambi3
Dheny WahyudhiUniversitas Jambi3
Luki AbdullahIPB University2
Asnath Maria FuahAfiliasi tidak diketahui2
Herry LiyusUniversitas Jambi2
Dwi Purno WidekdoUniversity of Brawijaya2
Wayan Firdaus MahmudyUniversity of Brawijaya1
Achmad RidokUniversity of Brawijaya1
Cece SumantriIPB University1
Asep GunawanIPB University1
Ratna Sholatia HarahapIPB University1
Kasita ListyariniIPB University1
Salman YusufAfiliasi tidak diketahui1
Rachmat SomanjayaAfiliasi tidak diketahui1
Mohamad Agus SetiadiAfiliasi tidak diketahui1
Agung Prastyo NugrohoAfiliasi tidak diketahui1
Merryafinola IfaniAfiliasi tidak diketahui1
Suhartati SuhartatiAfiliasi tidak diketahui1
Anhar Faisal FananiUniversitas Nahdlatul Ulama Lampung1
Komang Gede WiryawanIPB University1
Salundik SalundikAfiliasi tidak diketahui1
La Ode Safiun ArihiUniversitas Halu Oleo1
Hikmawati HikmawatiAfiliasi tidak diketahui1
Irdam IrdamAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://jtrolis.ub.ac.id/index.php/jtrolis/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en">Antioxidant Activity of Baby Java Citrus Peel Extract Promotes Lung Tissue Repair in Mice Challenged by Lipopolysaccharides: Antioxidant Activity of BJE Promotes Lung Tissue Repair</dc:title>
	<dc:creator xml:lang="en">Rachmawati, Farida</dc:creator>
	<dc:creator xml:lang="en">Sari, Fikriya Novita</dc:creator>
	<dc:creator xml:lang="en">Sakti, Sefihara Paramitha</dc:creator>
	<dc:creator xml:lang="en">Sakti, Muhammad Wisam Wira</dc:creator>
	<dc:creator xml:lang="en">Rahayu, Sri</dc:creator>
	<dc:creator xml:lang="en">Soewondo, Aris</dc:creator>
	<dc:creator xml:lang="en">Rifa'i, Muhaimin</dc:creator>
	<dc:subject xml:lang="en">Acute lung injury</dc:subject>
	<dc:subject xml:lang="en">Antioxidant</dc:subject>
	<dc:subject xml:lang="en">Baby Java citrus peel</dc:subject>
	<dc:subject xml:lang="en">MDA</dc:subject>
	<dc:subject xml:lang="en">Nrf2</dc:subject>
	<dc:description xml:lang="en">Acute lung injury tends to be induced by infection or sepsis that disrupt alveolar and vascular permeability, neutrophil influx, and edema. Those impairments are worsened by the increase of oxidative stress along with hyperinflammation response. Oxidative stress in lung tissue could be indicated by malondialdehyde (MDA) and nuclear factor erythroid 2-related factor 2 (Nrf2) expression. This research aimed to evaluate the efficacy of Baby Java citrus peel extract (BJE) in suppressing oxidative stress and preventing lung injury in lipopolysaccharides (LPS)-induced mice. Twenty-five male BALB/c mice were divided into five groups consisting of untreated (N), LPS (A), and LPS-induced followed by treatment using BJE at various doses: 75 mg/kg BW (BJE-1), 105 mg/kg BW (BJE-2), and 150 mg/kg BW (BJE-3). Lungs were isolated for histopathological analysis also detection of MDA and Nrf2 using flow cytometry. BJE at the dose of 105 mg/kg BW could inhibit the alteration of lung histology following LPS challenge including alveolar and interstitial neutrophil infiltration, proteinaceous debris, and septal thickening. The same dose also showed good potency in suppressing MDA and Nrf2 levels as oxidative stress indicators. Our findings demonstrated protective effects of Baby Java citrus peel in acute lung injury and oxidative stress prevention after LPS exposure.</dc:description>
	<dc:publisher xml:lang="en">Journal of Tropical Life Science</dc:publisher>
	<dc:date>2024-05-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/3121</dc:identifier>
	<dc:identifier>10.11594/jtls.14.02.03</dc:identifier>
	<dc:source xml:lang="en">Journal of Tropical Life Science; Vol. 14 No. 2 (2024); 229 – 236</dc:source>
	<dc:source>2527-4376</dc:source>
	<dc:source>2087-5517</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/3121/727</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2024 Journal of Tropical Life Science</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by-nc/4.0</dc:rights>
</oai_dc:dc>