Melola Discovery

← Melola Discovery

Akses terbuka Jurnal SINTA 1

Natural Deep Eutectic Solvent–Extracted Old and Young Mangrove Avicennia marina Leaves: Comparative Antibacterial Activity Against Propionibacterium acnes

Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences · Vol. 15 No. 3 (2026) · hlm. 575–590

DOI
10.11594/jtls.15.03.13
ISSN
2527-4376, 2087-5517
Terbit
2026-03-09
Penerbit
Journal of Tropical Life Science
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc/4.0

Abstrak

Acne vulgaris is a common inflammatory skin disorder largely associated with the proliferation of Propionibacterium acnes. Although antibiotics are widely used for acne treatment, the increasing incidence of antibiotic resistance necessitates the exploration of effective natural alternatives. Mangrove plants are known to contain diverse bioactive compounds with antimicrobial potential. This study aimed to evaluate the antibacterial activity of Natural Deep Eutectic Solvent (NADES) extracts derived from young and old leaves of Avicennia marina against P. acnes. Extraction was conducted using citric acid–glucose-based NADES with different molar ratios: P1 (1:1), P2 (2:1), P3 (3:1), and P4 (4:1), to assess the effect of solvent composition on antibacterial performance. Antibacterial activity was determined using inhibition zone assays, while molecular docking analysis was performed to investigate interactions between extracted metabolites and P. acnes target proteins. The results showed that both young and old leaf extracts exhibited significant antibacterial activity, strongly influenced by the NADES formulation. Young leaf extracts produced the largest inhibition zone with the P4 formulation (24.51±0.75 mm) and the smallest with P1 (21.63±0.67 mm). Similarly, old leaf extracts showed maximum inhibition in P4 (37.38±4.34 mm) and minimum inhibition in P1 (22.62±1.40 mm). Increasing the proportion of citric acid enhanced the extraction of bioactive compounds responsible for antibacterial activity. Molecular docking confirmed strong binding affinities between key metabolites and P. acnes target proteins, supporting the experimental findings. Thus, NADES extracts of A. marina leaves, particularly those prepared using a 4:1 citric acid–glucose ratio, demonstrate strong potential as natural antibacterial agents for acne prevention and treatment.

Kata kunci

Jaringan kolaborasi para penulis

40 penulis · 132 tautan kepenulisan bersama · menampilkan 40 yang paling banyak terhubung

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

  • Hasanuddin University
  • Afiliasi tidak diketahui
  • Organisasi berbeda
  • Organisasi sama
  • Afiliasi tidak diketahui
  • Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel
Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Happy NursyamAfiliasi tidak diketahui3
Anies ChamidahAfiliasi tidak diketahui3
Jayana Suryana KembaraAfiliasi tidak diketahui2
Nursinah AmirHasanuddin University2
Hardoko HardokoAfiliasi tidak diketahui2
Titik Dwi SulistiyatiAfiliasi tidak diketahui2
Hefni Citra AfriliaAfiliasi tidak diketahui2
Hadrian Indra MapaAfiliasi tidak diketahui1
Visman VismanAfiliasi tidak diketahui1
Hasrun HasrunAfiliasi tidak diketahui1
Ijang AsbarAfiliasi tidak diketahui1
Devi Faustine Elvina NuryadinAfiliasi tidak diketahui1
Anne Mumtaza PutriAfiliasi tidak diketahui1
Ginanjar PratamaAfiliasi tidak diketahui1
Bhatara Ayi MeataAfiliasi tidak diketahui1
Sakinah HaryatiAfiliasi tidak diketahui1
Dini SurilayaniAfiliasi tidak diketahui1
Ato UdinAfiliasi tidak diketahui1
Aris MunandarAfiliasi tidak diketahui1
Astry Ayu PraharsiniAfiliasi tidak diketahui1
Ervina ErvinaAfiliasi tidak diketahui1
Muhammad BasirAfiliasi tidak diketahui1
Fivo FreitasAfiliasi tidak diketahui1
Hamka NapingAfiliasi tidak diketahui1
Cahya Intan SalsabilaAfiliasi tidak diketahui1
Mirza Gulam AhmadAfiliasi tidak diketahui1
Liliek SoeprijadiAfiliasi tidak diketahui1
Natalia Prodiana SetiawatiAfiliasi tidak diketahui1
Trisna NingsihAfiliasi tidak diketahui1
Agusta Putri Balqis Linda SoeharsoAfiliasi tidak diketahui1

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) http://jtrolis.ub.ac.id/index.php/jtrolis/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Natural Deep Eutectic Solvent–Extracted Old and Young Mangrove Avicennia marina Leaves: Comparative Antibacterial Activity Against Propionibacterium acnes</dc:title>
	<dc:creator xml:lang="en">Djamaludin, Heder</dc:creator>
	<dc:creator xml:lang="en">Firdaus, Shelina Innasa</dc:creator>
	<dc:creator xml:lang="en">Suprayitno, Eddy</dc:creator>
	<dc:creator xml:lang="en">Yahya, Yahya</dc:creator>
	<dc:creator xml:lang="en">Arisandi, Desy</dc:creator>
	<dc:creator xml:lang="en">Ahmad, Mirza Gulam</dc:creator>
	<dc:creator xml:lang="en">Tambunan, Jeny Ernawati</dc:creator>
	<dc:creator xml:lang="en">Ahmad, Nurul Hawa</dc:creator>
	<dc:creator xml:lang="en">Ramli, Nurul Shazini</dc:creator>
	<dc:creator xml:lang="en">Kartikaningsih, Hartati</dc:creator>
	<dc:subject xml:lang="en">Antimicrobial agents</dc:subject>
	<dc:subject xml:lang="en">Green extraction technology</dc:subject>
	<dc:subject xml:lang="en">Mangrove-derived compounds</dc:subject>
	<dc:subject xml:lang="en">Sustainable bioactive resources</dc:subject>
	<dc:subject xml:lang="en">Food Security</dc:subject>
	<dc:description xml:lang="en">Acne vulgaris is a common inflammatory skin disorder largely associated with the proliferation of Propionibacterium acnes. Although antibiotics are widely used for acne treatment, the increasing incidence of antibiotic resistance necessitates the exploration of effective natural alternatives. Mangrove plants are known to contain diverse bioactive compounds with antimicrobial potential. This study aimed to evaluate the antibacterial activity of Natural Deep Eutectic Solvent (NADES) extracts derived from young and old leaves of Avicennia marina against P. acnes. Extraction was conducted using citric acid–glucose-based NADES with different molar ratios: P1 (1:1), P2 (2:1), P3 (3:1), and P4 (4:1), to assess the effect of solvent composition on antibacterial performance. Antibacterial activity was determined using inhibition zone assays, while molecular docking analysis was performed to investigate interactions between extracted metabolites and P. acnes target proteins. The results showed that both young and old leaf extracts exhibited significant antibacterial activity, strongly influenced by the NADES formulation. Young leaf extracts produced the largest inhibition zone with the P4 formulation (24.51±0.75 mm) and the smallest with P1 (21.63±0.67 mm). Similarly, old leaf extracts showed maximum inhibition in P4 (37.38±4.34 mm) and minimum inhibition in P1 (22.62±1.40 mm). Increasing the proportion of citric acid enhanced the extraction of bioactive compounds responsible for antibacterial activity. Molecular docking confirmed strong binding affinities between key metabolites and P. acnes target proteins, supporting the experimental findings. Thus, NADES extracts of A. marina leaves, particularly those prepared using a 4:1 citric acid–glucose ratio, demonstrate strong potential as natural antibacterial agents for acne prevention and treatment.</dc:description>
	<dc:publisher xml:lang="en">Journal of Tropical Life Science</dc:publisher>
	<dc:date>2026-03-09</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/3832</dc:identifier>
	<dc:identifier>10.11594/jtls.15.03.13</dc:identifier>
	<dc:source xml:lang="en">Journal of Tropical Life Science; Vol. 15 No. 3; 575 – 590</dc:source>
	<dc:source>2527-4376</dc:source>
	<dc:source>2087-5517</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jtrolis.ub.ac.id/index.php/jtrolis/article/view/3832/825</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2026 Journal of Tropical Life Science</dc:rights>
	<dc:rights xml:lang="en">https://creativecommons.org/licenses/by-nc/4.0</dc:rights>
</oai_dc:dc>