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The Activity of Mixed Microalgae Polysaccharides from Indonesia as Anti-Malaria in Vitro

Jurnal Ilmiah Perikanan dan Kelautan · Vol. 14 No. 2 (2022) · hlm. 396–403

DOI
10.20473/jipk.v14i2.34766
ISSN
2528-0759, 2085-5842
Terbit
2022-08-30
Penerbit
Faculty of Fisheries and Marine Universitas Airlangga
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-sa/4.0

Abstrak

Highlight Research One of the content of microalgae that is beneficial for health is polysaccharides Polysaccharides of Indonesian microalgae can be promoted as anti-malarial Polysaccharides from Glagah, Spirulina and East Java microalgae inhibited the growth of plasmodium in vitro and had IC50 values of 3.18 µg/mL, 5.43µg/mL and 9.87 µg/mL, respectively Abstract Malaria is an infectious disease caused by protozoan parasites of the genus Plasmodium that categorized as deadliest diseases in the world. Artemisinin and its derivatives are still recommended drugs for malaria therapy, however, there have been indications that Plasmodium parasites are resistant to this drug. Therefore, a study on polysaccharides from microalgae may be a potential as bioactive compound for anti-malaria. The aim of this study was to determine the effectiveness of the mixed microalgae polysaccharides as anti-malarial in vitro. Polysaccharides were extracted from three microalgae Spirulina sp., mixed microalgae Glagah and mixed microalgae East Java using the alkaline extraction method. The anti-malarial activity test refers to the concentration of polysaccharides used in calculating the IC50 value by probit analysis. The concentration of polysaccharides of the three microalgae used were 0; 0.01; 0.01, 1, 10 and 100 µg/mL. The results showed that the IC50 values of polysaccharides of Glagah, Spirulina sp. and East Java microalgae were 3.18 µg/mL, 5.43µg/mL, and 9.87 µg/mL, respectively. In Conclusion, polysaccharides of Indonesian mixed microalgae can be promoted as anti-malarial.

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  • Universitas Gadjah Mada
  • Universitas Airlangga
  • IPB University
  • National Research and Innovation Agency
  • Bandung Institute of Technology
  • Universitas Ahmad Dahlan
  • Diponegoro University
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Rekan penulisOrganisasiArtikel bersama
Tia ErfiantiUniversitas Gadjah Mada10
Rochmadi RochmadiUniversitas Gadjah Mada9
Renata Adaranyssa Egistha PutriUniversitas Gadjah Mada5
Brilian Ryan SadewoUniversitas Gadjah Mada5
Budhijanto BudhijantoUniversitas Gadjah Mada4
Dedy KurniantoNational Research and Innovation Agency4
Budi Setiadi DaryonoUniversitas Gadjah Mada4
Iskandar Zulkarnaen SiregarIPB University3
Siti JamilatunUniversitas Ahmad Dahlan3
Khusnul Qonita MaghfirohUniversitas Gadjah Mada3
Ria AmeliaUniversitas Gadjah Mada3
Dedy KurniantoUniversitas Gadjah Mada3
Hadiyanto HadiyantoDiponegoro University3
Mufasirin MufasirinUniversitas Airlangga3
Endang SuprihatiUniversitas Airlangga3
Siti MudrikahUniversitas Gadjah Mada3
Nugroho DewayantoUniversitas Gadjah Mada3
Angga Puja AsianduUniversitas Gadjah Mada3
Aswin Rafif KhairullahNational Research and Innovation Agency3
Dwi Umi SiswantiUniversitas Gadjah Mada2
Ratna Dewi KusumaningtyasState University of Semarang2
Eni BudiyatiMuhammadiyah University of Surakarta2
Panut MulyonoUniversitas Gadjah Mada2
Wusana Agung WibowoSebelas Maret University2
Rochim Bakti CahyonoUniversitas Gadjah Mada2
Adam AstitiUniversitas Gadjah Mada2
Istini NurafifahUniversitas Gadjah Mada2
Heni PuspitasariUniversitas Airlangga2
Eduardus Bimo AksonoUniversitas Airlangga2
Sri Agus SudjarwoUniversitas Airlangga2
Ira Sari YudaniayantiUniversitas Airlangga2

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/index.php/JIPK/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">The Activity of Mixed Microalgae Polysaccharides from Indonesia as Anti-Malaria in Vitro</dc:title>
	<dc:creator>Pujiyanto, Mahendra </dc:creator>
	<dc:creator>Afililla, Zhaza </dc:creator>
	<dc:creator>Maslachah, Lilik </dc:creator>
	<dc:creator>Widiyatno, Thomas Valentinus </dc:creator>
	<dc:creator>Koerniawan, Mochamad Donny </dc:creator>
	<dc:creator>Suyono, Eko Agus </dc:creator>
	<dc:creator>Budiman, Arief </dc:creator>
	<dc:creator>Siregar, Ulfah Juniarti </dc:creator>
	<dc:creator>Suwanti, Lucia Tri</dc:creator>
	<dc:subject xml:lang="en-US">Anti-Malaria Drug</dc:subject>
	<dc:subject xml:lang="en-US">Infectious Disease</dc:subject>
	<dc:subject xml:lang="en-US">Malaria</dc:subject>
	<dc:subject xml:lang="en-US">Tropical Disease</dc:subject>
	<dc:description xml:lang="en-US">Highlight Research

One of the content of microalgae that is beneficial for health is polysaccharides
Polysaccharides of Indonesian microalgae can be promoted as anti-malarial
Polysaccharides from Glagah, Spirulina and East Java microalgae inhibited the growth of plasmodium in vitro and had IC50 values of 3.18 µg/mL, 5.43µg/mL and 9.87 µg/mL, respectively

 
Abstract
Malaria is an infectious disease caused by protozoan parasites of the genus Plasmodium that categorized as deadliest diseases in the world. Artemisinin and its derivatives are still recommended drugs for malaria therapy, however, there have been indications that Plasmodium parasites are resistant to this drug. Therefore, a study on polysaccharides from microalgae may be a potential as bioactive compound for anti-malaria. The aim of this study was to determine the effectiveness of the mixed microalgae polysaccharides as anti-malarial in vitro. Polysaccharides were extracted from three microalgae Spirulina sp., mixed microalgae Glagah and mixed microalgae East Java using the alkaline extraction method. The anti-malarial activity test refers to the concentration of polysaccharides used in calculating the IC50 value by probit analysis.  The concentration of polysaccharides of the three microalgae used were 0; 0.01; 0.01, 1, 10 and 100 µg/mL. The results showed that the IC50 values of polysaccharides of Glagah, Spirulina sp. and East Java microalgae were 3.18 µg/mL, 5.43µg/mL, and 9.87 µg/mL, respectively. In Conclusion, polysaccharides of Indonesian mixed microalgae can be promoted as anti-malarial.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Fisheries and Marine Universitas Airlangga</dc:publisher>
	<dc:date>2022-08-30</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:format>text/xml</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/JIPK/article/view/34766</dc:identifier>
	<dc:identifier>10.20473/jipk.v14i2.34766</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Ilmiah Perikanan dan Kelautan; Vol. 14 No. 2 (2022): JURNAL ILMIAH PERIKANAN DAN KELAUTAN; 396-403</dc:source>
	<dc:source>2528-0759</dc:source>
	<dc:source>2085-5842</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/JIPK/article/view/34766/22310</dc:relation>
	<dc:relation>https://e-journal.unair.ac.id/JIPK/article/view/34766/40775</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Jurnal Ilmiah Perikanan dan Kelautan</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
</oai_dc:dc>