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Saltwater Fish Nanoparticles: Biological Effects on COL1A1 Expression in Fetal Mice and Tablet Formula Optimization

Jurnal Ilmiah Perikanan dan Kelautan · Vol. 18 No. 1 (2025) · hlm. 155–166

DOI
10.20473/jipk.v18i1.76746
ISSN
2528-0759, 2085-5842
Terbit
2025-10-31
Penerbit
Faculty of Fisheries and Marine Universitas Airlangga
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-sa/4.0

Abstrak

Graphical Abstract Highlight Research Saltwater fish Nano powder modulates the expression of matrix proteins, influencing early dental tissue development. Administration significantly decreases COL1A1 expression in fetal mouse teeth, affecting biomineralization. Increasing talc concentration improves flowability and formulation stability by reducing angle of repose, Carr’s index, and Hausner ratio. Findings suggest marine-derived nanoparticles regulate cellular differentiation during dental development. Supports potential applications of marine natural materials in prenatal nutrition and dental tissue engineering. Abstract Saltwater fish nanoparticle-based tablets represent a novel nutritional strategy aimed enhancing dental hard tissue density, particularly enamel. These tablets incorporate bioactive proteins, omega-3 fatty acids, and essential minerals such as calcium, phosphate, and magnesium to support enamel biomineralization. The nanoparticle formulation facilitates efficient cellular absorption, thereby increasing the expression of key enamel proteins like collagen type I alpha 1 chain (COL1A1) during enamel matrix development. This study investigated the effect of saltwater fish nanoparticles on COL1A1 expression in ameloblast cells and evaluated the physicochemical properties of tablets with talc concentrations of 1%, 5%, and 10%. Using a true experimental design with a post-test only control group, two groups of mice were assigned: a control group fed standard diet, and a treatment group fed a standard diet supplemented with saltwater fish nanoparticles (2.17 mg/0.5 mL). Tablet formulations were analyzed across the three talc concentrations. Data were subjected to independent T-tests for COL1A1 expression and One-way ANOVA for physicochemical properties. Results revealed a significant reduction in COL1A1 expression in the treatment group. Additionally, talc concentration significantly influenced tablet physicochemical characteristics, with the 10% talc formulation exhibiting the most optimal properties. These findings suggest potential for nanoparticle-based nutritional interventions to promote enamel formation.

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  • Sultan Agung Islamic University
  • Aligarh Muslim University
  • Universitas Airlangga
  • Politeknik Negeri Jember
  • Riau University
  • Universiti Sains Islam Malaysia
  • Badan Pengkajian dan Penerapan Teknologi
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Rekan penulisOrganisasiArtikel bersama
Seno PradopoUniversitas Airlangga4
Yayun Siti RochmahSultan Agung Islamic University4
Zurairah IbrahimUniversiti Sains Islam Malaysia4
I Ketut SudianaUniversitas Airlangga2
Regilia Shinta MayangsariSultan Agung Islamic University2
- SuparmiAfiliasi tidak diketahui2
Savira Nurazky YuniarSultan Agung Islamic University2
Novia IndasariSultan Agung Islamic University2
Arlina NurhapsariSultan Agung Islamic University2
Veramita Nanda PradanaSultan Agung Islamic University1
Ratnawati RatnawatiSultan Agung Islamic University1
S. AbiramiAfiliasi tidak diketahui1
Tabassum NawabAligarh Muslim University1
Geeta RajputAligarh Muslim University1
Muhamad Hafiidh Naafi’yanAfiliasi tidak diketahui1
Agus Hadi PrayitnoPoliteknik Negeri Jember1
Faradinda LorenzaPoliteknik Negeri Jember1
Taufik HidayatBadan Pengkajian dan Penerapan Teknologi1
Sumarto SumartoRiau University1
Suparmi SuparmiAfiliasi tidak diketahui1
Nur Ira SariRiau University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/index.php/JIPK/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Saltwater Fish Nanoparticles: Biological Effects on COL1A1 Expression in Fetal Mice and Tablet Formula Optimization</dc:title>
	<dc:creator>Christiono, Sandy</dc:creator>
	<dc:creator>Hutami, Islamy Rahma</dc:creator>
	<dc:creator>Suparmi, Suparmi</dc:creator>
	<dc:creator>Afroz, Shaista</dc:creator>
	<dc:creator>Clarasya, Amara Danish</dc:creator>
	<dc:creator>Ahmad, Rayyan Orvin Pradipta</dc:creator>
	<dc:creator>Subiyono, Amelia Febriani</dc:creator>
	<dc:subject xml:lang="en-US">nanopartikel</dc:subject>
	<dc:subject xml:lang="en-US">Saltwater Fish</dc:subject>
	<dc:subject xml:lang="en-US">COL1A1 expression</dc:subject>
	<dc:subject xml:lang="en-US">Fetal tooth development</dc:subject>
	<dc:subject xml:lang="en-US">Tablet formulation</dc:subject>
	<dc:subject xml:lang="en-US">Nanoparticles,   Saltwater fish COL1A1 expression Fetal tooth development Tablet formulation</dc:subject>
	<dc:description xml:lang="en-US">Graphical Abstract 

Highlight Research

Saltwater fish Nano powder modulates the expression of matrix proteins, influencing early dental tissue development.
Administration significantly decreases COL1A1 expression in fetal mouse teeth, affecting biomineralization.
Increasing talc concentration improves flowability and formulation stability by reducing angle of repose, Carr’s index, and Hausner ratio.
Findings suggest marine-derived nanoparticles regulate cellular differentiation during dental development.
Supports potential applications of marine natural materials in prenatal nutrition and dental tissue engineering.

 
Abstract
Saltwater fish nanoparticle-based tablets represent a novel nutritional strategy aimed enhancing dental hard tissue density, particularly enamel. These tablets incorporate bioactive proteins, omega-3 fatty acids, and essential minerals such as calcium, phosphate, and magnesium to support enamel biomineralization. The nanoparticle formulation facilitates efficient cellular absorption, thereby increasing the expression of key enamel proteins like collagen type I alpha 1 chain (COL1A1) during enamel matrix development. This study investigated the effect of saltwater fish nanoparticles on COL1A1 expression in ameloblast cells and evaluated the physicochemical properties of tablets with talc concentrations of 1%, 5%, and 10%. Using a true experimental design with a post-test only control group, two groups of mice were assigned: a control group fed standard diet, and a treatment group fed a standard diet supplemented with saltwater fish nanoparticles (2.17 mg/0.5 mL). Tablet formulations were analyzed across the three talc concentrations. Data were subjected to independent T-tests for COL1A1 expression and One-way ANOVA for physicochemical properties. Results revealed a significant reduction in COL1A1 expression in the treatment group. Additionally, talc concentration significantly influenced tablet physicochemical characteristics, with the 10% talc formulation exhibiting the most optimal properties. These findings suggest potential for nanoparticle-based nutritional interventions to promote enamel formation.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Fisheries and Marine Universitas Airlangga</dc:publisher>
	<dc:date>2025-10-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>text/xml</dc:format>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/JIPK/article/view/76746</dc:identifier>
	<dc:identifier>10.20473/jipk.v18i1.76746</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Ilmiah Perikanan dan Kelautan; Vol. 18 No. 1 (2026): JURNAL ILMIAH PERIKANAN DAN KELAUTAN; 155-166</dc:source>
	<dc:source>2528-0759</dc:source>
	<dc:source>2085-5842</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/JIPK/article/view/76746/40603</dc:relation>
	<dc:relation>https://e-journal.unair.ac.id/JIPK/article/view/76746/35534</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 Jurnal Ilmiah Perikanan dan Kelautan</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
</oai_dc:dc>