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Chitosan nanoparticle of hCG (Human Chorionic Gonadotrophin) hormone in increasing induction of dairy cattle ovulation

Jurnal Ilmu Ternak dan Veteriner · Vol. 21 No. 1 (2016) · hlm. 34–40

DOI
10.14334/jitv.v21i1.1343
ISSN
2252-696X, 0853-7380
Terbit
2016-03-31
Penerbit
APPERTANI
Bahasa
eng
Lisensi
creativecommons.org/licenses/by/4.0

Abstrak

A controlled release delivery system of human chorionic gonadotropin (hCG) hormone helps to overcome the rapid degradation of hCG hormone in the blood, to avoid the use of multiple injections for ovulation induction and to enhance reproductive efficacy. This study aimed to prepare chitosan nanoparticles hCG (CS-NPh) and to determine its efficacy as nasal spray of CS-NPh. The observed parameters include physico-chemical characteristics of CS-NPh and the follicle size, corpus luteum, the time of ovulation and onset of estrus performed after administration of CS-NPh as a nasal spray compared with intramuscular hCG (control) at a dose of 1,000 IU in dairy cattle. The result showed that the formation of the hormone hCG nanoparticles is still in the size range of nanoparticles with a well and more stable molecular mass distribution, so it can be used as a carrier component of hormones. The result showed that the time of ovulation after hCG by intramuscular (day to 3.13±0.35) and CS-NPh as a nasal spray (days to 3.33±0.49) with the follicle size by 1.62±0.22 and 1.76±0.28 cm showed no significant differences (p 0.05), likewise the size of the corpus luteum and onset of oestrus. This indicates that administration of CS-NPh as a nasal spray can be used in enhancing the induction of ovulation in dairy cattles.Key Words: Nanoparticles, hCG, Nasal Spray, Ovulation

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Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Chitosan nanoparticle of hCG (Human Chorionic Gonadotrophin) hormone in increasing induction of dairy cattle ovulation</dc:title>
	<dc:creator>Pamungkas, Fitra Aji</dc:creator>
	<dc:creator>Sianturi, Ria Sari Gail</dc:creator>
	<dc:creator>Wina, Elizabeth</dc:creator>
	<dc:creator>Kusumaningrum, Diana Andrianita</dc:creator>
	<dc:subject xml:lang="en-US">Nanoparticles; hCG; Nasal Spray; Ovulation</dc:subject>
	<dc:subject xml:lang="en-US"></dc:subject>
	<dc:description xml:lang="en-US">A controlled release delivery system of human chorionic gonadotropin (hCG) hormone helps to overcome the rapid degradation of hCG hormone in the blood, to avoid the use of multiple injections for ovulation induction and to enhance reproductive efficacy. This study aimed to prepare chitosan nanoparticles hCG (CS-NPh) and to determine its efficacy as nasal spray of CS-NPh. The observed parameters include physico-chemical characteristics of CS-NPh and the follicle size, corpus luteum, the time of ovulation and onset of estrus performed after administration of CS-NPh as a nasal spray compared with intramuscular hCG (control) at a dose of 1,000 IU in dairy cattle. The result showed that the formation of the hormone hCG nanoparticles is still in the size range of nanoparticles with a well and more stable molecular mass distribution, so it can be used as a carrier component of hormones. The result showed that the time of ovulation after hCG by intramuscular (day to 3.13±0.35) and CS-NPh as a nasal spray (days to 3.33±0.49) with the follicle size by 1.62±0.22 and 1.76±0.28 cm showed no significant differences (p 0.05), likewise the size of the corpus luteum and onset of oestrus. This indicates that administration of CS-NPh as a nasal spray can be used in enhancing the induction of ovulation in dairy cattles.Key Words: Nanoparticles, hCG, Nasal Spray, Ovulation</dc:description>
	<dc:publisher xml:lang="en-US">APPERTANI</dc:publisher>
	<dc:contributor xml:lang="en-US"></dc:contributor>
	<dc:date>2016-03-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://medpub.appertani.org/index.php/jitv/article/view/1343</dc:identifier>
	<dc:identifier>10.14334/jitv.v21i1.1343</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Ilmu Ternak dan Veteriner; Vol 21, No 1 (2016): MARCH 2016; 34-40</dc:source>
	<dc:source>2252-696X</dc:source>
	<dc:source>0853-7380</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://medpub.appertani.org/index.php/jitv/article/view/1343/pdf-</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2016 Indonesian Journal of Animal and Veterinary Sciences</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by/4.0</dc:rights>
</oai_dc:dc>