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Correlation between Neutrophil/Lymphocyte Ratio (NLR), lipid profile, lesion location and vascular cognitive impairment in acute ischemic stroke patients

Jurnal Keperawatan Padjadjaran · Vol. 12 No. 2 (2024) · hlm. 144–152

DOI
10.24198/jkp.v12i2.2526
ISSN
2442-7276, 2338-5324
Terbit
2024-08-23
Penerbit
Faculty of Nursing Universitas Padjadjaran
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-sa/4.0/

Abstrak

Background: Stroke is the leading cause of long-term disability with significant clinical and socioeconomic impact worldwide. Hyperlipidemia and inflammation play major roles in ischemic stroke. This research focuses on the correlation of three factors, namely Neutrophil-Lymphocyte Ratio (NLR), lipid profile, and lesion location, with Vascular Cognitive Impairment (VCI). These factors may serve as potential predictors for VCI. Purpose: This research aims to study the correlation between NLR, lipid profile, and lesion location with vascular cognitive impairment. Besides, this research aims to explore those potential biomarkers as predictors of vascular cognitive impairment. Methods: This was a cross-sectional study which included 107 patients diagnosed with ischemic stroke from February 2022 to January 2023 with a history of admission to the hospital within 72 hours. After signed an informed consent form, every patient had history taking, physical exam, lipid profile, routine blood test, Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment Indonesian Version (MoCA-Ina) on the first hospital day. Statistical tests were done with Spearman correlation method. Results: The data distribution was not normal for INR and MoCA-INA values (p<0.05). Total cholesterol was insignificantly (p=0.092) correlated with MoCA-INA score with low correlation value (r=-0.293). HDL was significantly (p=0.035) correlated with MoCA-INA score with moderate correlation value (r=0.461). LDL was significantly (p=0.028) correlated with MoCA-INA score with low correlation value (r=-0.387). Triglycerides was insignificantly (p=0.440) correlated with MoCA-INA score with very weak correlation value (r=-0.137). NLR was significantly (p=0.015) correlated with MoCA-INA score with moderate correlation value (r=-0.412). Conclusions: Lipid profile is correlated with cognitive impairment in post stroke patients, with HDL being a protective factor, and LDL as risk factor. NLR was associated with worse cognitive function and LDL was directly proportional to NLR. Lesion location reporting was highly heterogeneous and more uniformed reporting is recommended for future research.

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  • Sebelas Maret University
  • Muhammadiyah University of Surakarta
  • Institut National des Sciences Appliquées Centre Val de Loire
  • Diponegoro University
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Rekan penulisOrganisasiArtikel bersama
Subandi SubandiSebelas Maret University28
Lawly Arrel Dionnie GreatalyaAfiliasi tidak diketahui12
Suroto SurotoDiponegoro University12
Vivienne TjungSebelas Maret University12
Rudi IlhamsyahSebelas Maret University6
Dewi Hayu KiranaSebelas Maret University5
Faizal MuhammadSebelas Maret University5
Wilson ArpinSebelas Maret University5
Yeremia Suryo PratamaSebelas Maret University5
Cynthia Hanny LestariSebelas Maret University5
Christopher Daniel TristanSebelas Maret University5
Lestari HandayaniInstitut National des Sciences Appliquées Centre Val de Loire3
Umi Budi RahayuMuhammadiyah University of Surakarta1
Wanda Kurnia YudaMuhammadiyah University of Surakarta1
Yusuf PerdanaAfiliasi tidak diketahui1
Rinaldo Adi PratamaAfiliasi tidak diketahui1
Sumargono SumargonoAfiliasi tidak diketahui1
Muchtaruddin MansyurAfiliasi tidak diketahui1
Lugyanti SukrismanAfiliasi tidak diketahui1
Al RasyidAfiliasi tidak diketahui1
Jusuf MisbachAfiliasi tidak diketahui1
Jan S PurbaAfiliasi tidak diketahui1
Ina S TimanAfiliasi tidak diketahui1
Efta YudiarsahAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://jkp.fkep.unpad.ac.id/index.php/jkp/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Correlation between Neutrophil/Lymphocyte Ratio (NLR), lipid profile, lesion location and vascular cognitive impairment in acute ischemic stroke patients</dc:title>
	<dc:creator>Ristinawati, Ira</dc:creator>
	<dc:creator>Tan, Kenneth</dc:creator>
	<dc:creator>Benedictus, Benedictus</dc:creator>
	<dc:creator>Hafizhan, Muhammad</dc:creator>
	<dc:creator>Putra, Stefanus Erdana</dc:creator>
	<dc:creator>Suroto, Suroto</dc:creator>
	<dc:creator>Mirawati, Diah Kurnia</dc:creator>
	<dc:creator>Subandi, Subandi</dc:creator>
	<dc:creator>Danuaji, Rivan</dc:creator>
	<dc:creator>Budianto, Pepi</dc:creator>
	<dc:creator>Hambarsari, Yetty</dc:creator>
	<dc:creator>Hamidi, Baarid Luqman</dc:creator>
	<dc:creator>Prabaningtyas, Hanindia Riani</dc:creator>
	<dc:creator>Hutabarat, Ervina Arta Jayanti</dc:creator>
	<dc:creator>Tejomukti, Teddy</dc:creator>
	<dc:creator>Tedjo, Raden Andi Ario</dc:creator>
	<dc:subject xml:lang="en-US">cognitive</dc:subject>
	<dc:subject xml:lang="en-US">HDL</dc:subject>
	<dc:subject xml:lang="en-US">LDL</dc:subject>
	<dc:subject xml:lang="en-US">location</dc:subject>
	<dc:subject xml:lang="en-US">NLR</dc:subject>
	<dc:subject xml:lang="en-US">stroke</dc:subject>
	<dc:description xml:lang="en-US">Background: Stroke is the leading cause of long-term disability with significant clinical and socioeconomic impact worldwide. Hyperlipidemia and inflammation play major roles in ischemic stroke. This research focuses on the correlation of three factors, namely Neutrophil-Lymphocyte Ratio (NLR), lipid profile, and lesion location, with Vascular Cognitive Impairment (VCI). These factors may serve as potential predictors for VCI.
Purpose: This research aims to study the correlation between NLR, lipid profile, and lesion location with vascular cognitive impairment. Besides, this research aims to explore those potential biomarkers as predictors of vascular cognitive impairment.
Methods: This was a cross-sectional study which included 107 patients diagnosed with ischemic stroke from February 2022 to January 2023 with a history of admission to the hospital within 72 hours. After signed an informed consent form, every patient had history taking, physical exam, lipid profile, routine blood test, Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment Indonesian Version (MoCA-Ina) on the first hospital day. Statistical tests were done with Spearman correlation method.
Results: The data distribution was not normal for INR and MoCA-INA values (p&amp;lt;0.05).  Total cholesterol was insignificantly (p=0.092) correlated with MoCA-INA score with low correlation value (r=-0.293). HDL was significantly (p=0.035) correlated with MoCA-INA score with moderate correlation value (r=0.461). LDL was significantly (p=0.028) correlated with MoCA-INA score with low correlation value (r=-0.387). Triglycerides was insignificantly (p=0.440) correlated with MoCA-INA score with very weak correlation value (r=-0.137). NLR was significantly (p=0.015) correlated with MoCA-INA score with moderate correlation value (r=-0.412).
Conclusions: Lipid profile is correlated with cognitive impairment in post stroke patients, with HDL being a protective factor, and LDL as risk factor. NLR was associated with worse cognitive function and LDL was directly proportional to NLR. Lesion location reporting was highly heterogeneous and more uniformed reporting is recommended for future research.</dc:description>
	<dc:publisher xml:lang="en-US">Faculty of Nursing Universitas Padjadjaran</dc:publisher>
	<dc:date>2024-08-23</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jkp.fkep.unpad.ac.id/index.php/jkp/article/view/2526</dc:identifier>
	<dc:identifier>10.24198/jkp.v12i2.2526</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Keperawatan Padjadjaran; Vol. 12 No. 2 (2024): Jurnal Keperawatan Padjadjaran; 144-152</dc:source>
	<dc:source>2442-7276</dc:source>
	<dc:source>2338-5324</dc:source>
	<dc:source>10.24198/jkp.v12i2</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jkp.fkep.unpad.ac.id/index.php/jkp/article/view/2526/396</dc:relation>
	<dc:relation>10.24198/jkp.v9i1.1446.s771</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 Ira Ristinawati, Kenneth Tan, Benedictus Benedictus, Muhammad Hafizhan, Stefanus Erdana Putra, Suroto Suroto, Diah Kurnia Mirawati, Subandi Subandi, Rivan Danuaji, Pepi Budianto, Yetty Hambarsari, Baarid Luqman Hamidi, Hanindia Riani Prabaningtyas, Ervina Arta Jayanti Hutabarat, Teddy Tejomukti, Raden Andi Ario Tedjo</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-sa/4.0/</dc:rights>
</oai_dc:dc>