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Genetic Analysis of The Leptin Gene in Goats Based on GenBank DNA Sequences

Jurnal Medik Veteriner · Vol. 6 No. 1 (2023) · hlm. 125–131

DOI
10.20473/jmv.vol6.iss1.2023.125-131
ISSN
2581-012X, 2615-7497
Terbit
2023-04-01
Penerbit
Universitas Airlangga
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-sa/4.0

Abstrak

The Leptin gene is the gene that produces the leptin hormone, which is released from adipose tissue and can increase the productivity of animals. This study aimed to identify polymorphic nucleotides, changes in amino acid components, and species of goats based on GenBank Leptin DNA sequence data. A total of five goat leptin DNA sequences were extracted from NCBI GenBank data. The leptin DNA sequence was aligned with Bioedit to locate SNPs and amino acid changes. The tree produces cultivars grown using Clustal Omega Ver. 1.2.4. Based on the DNA sequencing results of leptin genes in five goats, five SNPs were located in the coding sequence (CDS), SNPs g.17T/A, g.43T/A, g.74G/A, g.93C/A. and d. 386A/G. SNP was a missense mutation and a silent mutation. The analysis of phylogenetic trees of Leptin showed that there were three breeds of goats in one branch and two breeds of goats in different branches. These results provided the first report for further studies on the genetic diversity of leptin genes in different local goat breeds.

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  • Diponegoro University
  • Universitas Islam Negeri Antasari Banjarmasin
  • Universitas Muslim Indonesia
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Ragil Angga PrastiyaAfiliasi tidak diketahui7
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Rimayanti RimayantiUniversitas Islam Negeri Antasari Banjarmasin6
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Hermin RatnaniAfiliasi tidak diketahui4
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Hartono HartonoDiponegoro University1
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Adi Kurniawan YusimDiponegoro University1
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Angga Aldilla GussmanAfiliasi tidak diketahui1
Samsidar SamsidarUniversitas Muslim Indonesia1
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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/JMV/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Genetic Analysis of The Leptin Gene in Goats Based on GenBank DNA Sequences</dc:title>
	<dc:creator>Amrullah, Muhammad Fajar</dc:creator>
	<dc:creator>Utomo, Budi</dc:creator>
	<dc:creator>Utama, Suzanita</dc:creator>
	<dc:creator>Suprayogi, Tri Wahyu</dc:creator>
	<dc:creator>Lestari, Tita Damayanti </dc:creator>
	<dc:creator>Restiadi, Tjuk Imam</dc:creator>
	<dc:creator>Belgania, Ristaqul Husna</dc:creator>
	<dc:subject xml:lang="en-US">genetic diversity</dc:subject>
	<dc:subject xml:lang="en-US">goat</dc:subject>
	<dc:subject xml:lang="en-US">leptin gene</dc:subject>
	<dc:subject xml:lang="en-US">phylogenetic tree</dc:subject>
	<dc:subject xml:lang="en-US">SNPs</dc:subject>
	<dc:description xml:lang="en-US">The Leptin gene is the gene that produces the leptin hormone, which is released from adipose tissue and can increase the productivity of animals. This study aimed to identify polymorphic nucleotides, changes in amino acid components, and species of goats based on GenBank Leptin DNA sequence data. A total of five goat leptin DNA sequences were extracted from NCBI GenBank data. The leptin DNA sequence was aligned with Bioedit to locate SNPs and amino acid changes. The tree produces cultivars grown using Clustal Omega Ver. 1.2.4. Based on the DNA sequencing results of leptin genes in five goats, five SNPs were located in the coding sequence (CDS), SNPs g.17T/A, g.43T/A, g.74G/A, g.93C/A. and d. 386A/G. SNP was a missense mutation and a silent mutation. The analysis of phylogenetic trees of Leptin showed that there were three breeds of goats in one branch and two breeds of goats in different branches. These results provided the first report for further studies on the genetic diversity of leptin genes in different local goat breeds.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Airlangga</dc:publisher>
	<dc:date>2023-04-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/JMV/article/view/40246</dc:identifier>
	<dc:identifier>10.20473/jmv.vol6.iss1.2023.125-131</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Medik Veteriner; Vol. 6 No. 1 (2023): April; 125-131</dc:source>
	<dc:source>2581-012X</dc:source>
	<dc:source>2615-7497</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/JMV/article/view/40246/24223</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Muhammad Fajar Amrullah, Budi Utomo, Suzanita Utama, Tri Wahyu Suprayogi, Tita Damayanti Lestari, Tjuk Imam Restiadi, Ristaqul Husna Belgania</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
</oai_dc:dc>