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Essential Oil of Patchouli Inhalation Exhibits An Anxiolytic-Like Effect in Mice: Elevated Plus-Maze Test

Jurnal Medik Veteriner · Vol. 6 No. 3 (2023) · hlm. 31–36

DOI
10.20473/jmv.vol6.iss3.2023.31-36
ISSN
2581-012X, 2615-7497
Terbit
2023-12-31
Penerbit
Universitas Airlangga
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-sa/4.0

Abstrak

Anxiety disorder is one of the important public health problems. This study aimed to find out whether patchouli (Pogostemon cablin (Blanco) Benth.) essential oil (PEO) has an anxiolytic-like effect in mice. A total of 20 mice were divided into five treatment groups i.e. (C1) was treated with 1 mg/kg of saline intraperitoneally; (C2) was treated with 1 mg/kg of diazepam intraperitoneally; (T1) 1% PEO inhalation, (T2) 2.5% PEO inhalation, and (T3) 5% PEO inhalation. All experimental animals were put in the Elevated Plus-Maze (EPM), observed for five minutes, and investigated the following parameters i.e. the total number of squares that are transverse in the open arms (STO), the number of visits to the open arms (VOA), the number of visits to the closed arms (VCA), the time spent in the open arms (TOA), and the time spent in the closed arms (TCA). In results, T1 and T2 groups had a minor impact on the VOA. T1 group also had little effect on TOA. Closed-arm activities (VCA and TCA) were unaffected by any of the treatments. The conclusion was revealed that T1 or less of PEO inhalation can potentially provide anxiolytic-like effects in mice.

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  • Universitas Airlangga
  • Universitas Hang Tuah
  • National Research and Innovation Agency
  • IPB University
  • Universitas Djuanda
  • Pusat Penelitian dan Pengembangan Peternakan
  • Universitas Halu Oleo
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Rekan penulisOrganisasiArtikel bersama
Erma SafitriUniversitas Airlangga6
Imam MustofaUniversitas Airlangga3
Tatik HernawatiUniversitas Airlangga3
Pudji SriantoUniversitas Airlangga2
Tita Damayanti LestariUniversitas Airlangga2
Tri Wahyu SuprayogiUniversitas Airlangga2
Herry Agoes HermadiUniversitas Airlangga2
Thomas Valentinus WidiyatnoUniversitas Airlangga2
Ira Sari YudaniayantiUniversitas Airlangga2
Aswin Rafif KhairullahNational Research and Innovation Agency2
Ratih Novita PrajaUniversitas Airlangga2
Maya Nurwartanti YunitaUniversitas Airlangga2
Tisya Yumn Al-ZuhrohUniversitas Airlangga2
Rima Parwati SariUniversitas Hang Tuah1
Retno Pudji RahayuUniversitas Airlangga1
Syamsulina ReviantiUniversitas Hang Tuah1
Widyasri PrananingrumUniversitas Hang Tuah1
Hansen KurniawanUniversitas Hang Tuah1
Aisah Faiz BachmidUniversitas Hang Tuah1
La Ode NafiuUniversitas Halu Oleo1
SubandriyoUniversitas Djuanda1
Bess TiesnamurtiPusat Penelitian dan Pengembangan Peternakan1
Ismeth InounuIPB University1
Tjuk Imam RestiadiUniversitas Airlangga1
Mitha Ardila RahmawatiUniversitas Airlangga1
Mas’ud HariadiUniversitas Airlangga1
Linda ListyoriniAfiliasi tidak diketahui1
Budi UtomoUniversitas Airlangga1
Syuhuud Arumbinang WajdiSatya Wacana Christian University1
Wurlina WurlinaUniversitas Airlangga1
Sri Pantja MadyawatiUniversitas Airlangga1
Enggar HardaningtyasAfiliasi tidak diketahui1
Made Bagus ErlanggaUniversitas Airlangga1

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/JMV/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Essential Oil of Patchouli Inhalation Exhibits An Anxiolytic-Like Effect in Mice: Elevated Plus-Maze Test</dc:title>
	<dc:creator>Johansyah, Fadilla Anita Kinksky</dc:creator>
	<dc:creator>Hestianah, Eka Pramyrtha </dc:creator>
	<dc:creator>Rimayanti, Rimayanti</dc:creator>
	<dc:creator>Hidajati, Nove</dc:creator>
	<dc:creator>Santoso, Kuncoro Puguh</dc:creator>
	<dc:creator>Sudjarwo, Sri Agus</dc:creator>
	<dc:creator>Hidayatik, Nanik</dc:creator>
	<dc:subject xml:lang="en-US">anxiety</dc:subject>
	<dc:subject xml:lang="en-US">elevated plus-maze test</dc:subject>
	<dc:subject xml:lang="en-US">essential oil</dc:subject>
	<dc:subject xml:lang="en-US">patchouli</dc:subject>
	<dc:subject xml:lang="en-US">public health</dc:subject>
	<dc:description xml:lang="en-US">Anxiety disorder is one of the important public health problems. This study aimed to find out whether patchouli (Pogostemon cablin (Blanco) Benth.) essential oil (PEO) has an anxiolytic-like effect in mice. A total of 20 mice were divided into five treatment groups i.e. (C1) was treated with 1 mg/kg of saline intraperitoneally; (C2) was treated with 1 mg/kg of diazepam intraperitoneally; (T1) 1% PEO inhalation, (T2) 2.5% PEO inhalation, and (T3) 5% PEO inhalation. All experimental animals were put in the Elevated Plus-Maze (EPM), observed for five minutes, and investigated the following parameters i.e. the total number of squares that are transverse in the open arms (STO), the number of visits to the open arms (VOA), the number of visits to the closed arms (VCA), the time spent in the open arms (TOA), and the time spent in the closed arms (TCA). In results, T1 and T2 groups had a minor impact on the VOA. T1 group also had little effect on TOA. Closed-arm activities (VCA and TCA) were unaffected by any of the treatments. The conclusion was revealed that T1 or less of PEO inhalation can potentially provide anxiolytic-like effects in mice.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Airlangga</dc:publisher>
	<dc:date>2023-12-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/JMV/article/view/46205</dc:identifier>
	<dc:identifier>10.20473/jmv.vol6.iss3.2023.31-36</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Medik Veteriner; Vol. 6 No. 3 (2023): Special Issue: International Conference on Veterinary Medicine and Health Sciences (ICVMHS); 31-36</dc:source>
	<dc:source>2581-012X</dc:source>
	<dc:source>2615-7497</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/JMV/article/view/46205/27570</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Fadilla Anita Kinksky Johansyah, Eka Pramyrtha Hestianah, Rimayanti, Nove Hidajati, Kuncoro Puguh Santoso, Sri Agus Sudjarwo, Nanik Hidayatik</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
</oai_dc:dc>