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Protective Effects of Apis Dorsata Honey Supplementation on Kidney Histopathology in Mice with Monosodium Glutamate Exposure

Jurnal Medik Veteriner · Vol. 6 No. 3 (2023) · hlm. 63–69

DOI
10.20473/jmv.vol6.iss3.2023.63-69
ISSN
2581-012X, 2615-7497
Terbit
2023-12-31
Penerbit
Universitas Airlangga
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-sa/4.0

Abstrak

This study was conducted to investigate the protective effects of Apis dorsata honey on the histopathological changes of the kidney in mice exposed to monosodium glutamate. This study used 25 male mice as the experimental animal which were divided into five groups with five replication, respectively i.e. (C-) was administered basal diet, (C+) was administered 4 mg/g BW MSG, (T1) was administered A. dorsata honey of 53.82 mg/20g BW followed by MSG 4 mg/g BW, (T2) was administered A. dorsata honey of 107.64 mg/20g BW followed by MSG 4 mg/g BW, and (T3) was administered A. dorsata honey of 161.46 g/20g BW followed by MSG 4 mg/g BW. All treatments were carried out orally for 52 days. This study was observed tubular epithelial hydropic degeneration, epithelial necrosis, and glomerular necrosis. Data were analyzed using Kruskal-Wallis test followed by the Mann-Whitney test. As a result, for the epithelial and glomerular necrosis variables, the T3 group showed significant results when compared with C+, T1, and T2 groups. Moreover, T3 was not significantly different from the C- group. It can be concluded that A. dorsata honey in T3 group could protect mice kidneys from the damaging effect of MSG.

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  • Universitas Islam Negeri Antasari Banjarmasin
  • Diponegoro University
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Rekan penulisOrganisasiArtikel bersama
Sri HidanahAfiliasi tidak diketahui13
Mohammad Anam Al ArifAfiliasi tidak diketahui9
Ira Sari YudaniayantiAfiliasi tidak diketahui8
Soeharsono SoeharsonoAfiliasi tidak diketahui7
Amung Logam SaputroAfiliasi tidak diketahui7
Rimayanti RimayantiUniversitas Islam Negeri Antasari Banjarmasin7
Aditya YudhanaAfiliasi tidak diketahui7
Mirni LamidAfiliasi tidak diketahui6
Maya Nurwartanti YunitaAfiliasi tidak diketahui6
Nenny HarijaniAfiliasi tidak diketahui5
Muhammad Anam Al-ArifAfiliasi tidak diketahui5
Suherni SusilowatiAfiliasi tidak diketahui5
Iwan Sahrial HamidAfiliasi tidak diketahui5
Tri Wahyu SuprayogiAfiliasi tidak diketahui4
Imam MustofaAfiliasi tidak diketahui4
Sri Pantja MadyawatiAfiliasi tidak diketahui4
Tita Damayanti LestariAfiliasi tidak diketahui4
Bodhi AgustonoAfiliasi tidak diketahui4
Ragil Angga PrastiyaAfiliasi tidak diketahui3
Tatik HernawatiAfiliasi tidak diketahui3
Pudji SriantoAfiliasi tidak diketahui3
Sunaryo Hadi WarsitoAfiliasi tidak diketahui3
Ahmad AswinAfiliasi tidak diketahui3
Diyantoro DiyantoroAfiliasi tidak diketahui3
Prima Ayu WibawatiAfiliasi tidak diketahui3
Boedi SetiawanAfiliasi tidak diketahui3
Herry Agoes HermadiAfiliasi tidak diketahui3
Wiwik Misaco YuniartiAfiliasi tidak diketahui3
Epy Muhammad LuqmanAfiliasi tidak diketahui3
Syarief Thaufik HidayatAfiliasi tidak diketahui2
Agustono AgustonoSebelas Maret University2
Budi UtomoDiponegoro University2
Wiwiek TyasningsihAfiliasi tidak diketahui2

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/JMV/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc)
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	<dc:title xml:lang="en-US">Protective Effects of Apis Dorsata Honey Supplementation on Kidney Histopathology in Mice with Monosodium Glutamate Exposure</dc:title>
	<dc:creator>Rao, Sherbrina Bai Seenivasa </dc:creator>
	<dc:creator>Widjiati, Widjiati</dc:creator>
	<dc:creator> Lokapirnasari, Widya Paramita</dc:creator>
	<dc:creator> Triakoso, Nusdianto</dc:creator>
	<dc:creator>Safitri, Erma </dc:creator>
	<dc:creator>Kuncorojakti, Suryo </dc:creator>
	<dc:creator>Proboningrat, Annise</dc:creator>
	<dc:subject xml:lang="en-US">Apis dorsata</dc:subject>
	<dc:subject xml:lang="en-US">health</dc:subject>
	<dc:subject xml:lang="en-US">honey</dc:subject>
	<dc:subject xml:lang="en-US">kidney</dc:subject>
	<dc:subject xml:lang="en-US">monosodium glutamate</dc:subject>
	<dc:description xml:lang="en-US">This study was conducted to investigate the protective effects of Apis dorsata honey on the histopathological changes of the kidney in mice exposed to monosodium glutamate. This study used 25 male mice as the experimental animal which were divided into five groups with five replication, respectively i.e. (C-) was administered basal diet, (C+) was administered 4 mg/g BW MSG, (T1) was administered A. dorsata honey of 53.82 mg/20g BW followed by MSG 4 mg/g BW, (T2) was administered A. dorsata honey of 107.64 mg/20g BW followed by MSG 4 mg/g BW, and (T3) was administered A. dorsata honey of 161.46 g/20g BW followed by MSG 4 mg/g BW. All treatments were carried out orally for 52 days. This study was observed tubular epithelial hydropic degeneration, epithelial necrosis, and glomerular necrosis. Data were analyzed using Kruskal-Wallis test followed by the Mann-Whitney test. As a result, for the epithelial and glomerular necrosis variables, the T3 group showed significant results when compared with C+, T1, and T2 groups. Moreover, T3 was not significantly different from the C- group. It can be concluded that A. dorsata honey in T3 group could protect mice kidneys from the damaging effect of MSG.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Airlangga</dc:publisher>
	<dc:date>2023-12-31</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/JMV/article/view/46242</dc:identifier>
	<dc:identifier>10.20473/jmv.vol6.iss3.2023.63-69</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Medik Veteriner; Vol. 6 No. 3 (2023): Special Issue: International Conference on Veterinary Medicine and Health Sciences (ICVMHS); 63-69</dc:source>
	<dc:source>2581-012X</dc:source>
	<dc:source>2615-7497</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/JMV/article/view/46242/27575</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Sherbrina Bai Seenivasa Rao, Widjiati, Widya Paramita Lokapirnasari, Nusdianto Triakoso, Erma Safitri, Suryo Kuncorojakti, Annise Proboningrat</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
</oai_dc:dc>