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Acute Toxicity of Ethanol Extract of Curcuma zedoaria Rosc (Zingiberaceae) Rhizomes on Brine Shrimp Larvae and Zebrafish Embryos

Jurnal Medik Veteriner · Vol. 7 No. 1 (2024) · hlm. 7–18

DOI
10.20473/jmv.vol7.iss1.2024.7-18
ISSN
2581-012X, 2615-7497
Terbit
2024-04-01
Penerbit
Universitas Airlangga
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-sa/4.0

Abstrak

Curcuma zedoaria Rosc (Zingiberaceae), known as white turmeric or temu putih, is commonly used as traditional medicine in Indonesia. The toxicity of this herb needs to be studied to improve its application. This study aimed to evaluate the toxicity of the crude ethanol extract of temu putih rhizome against brine shrimp (Artemia salina) larvae and zebrafish (Danio rerio) embryos and to analyze the potential active compounds contained in the extract. The crude ethanol extract showed a 50% lethal concentration value (LC50) at 588 ppm against brine shrimp larvae and 224 ppm against zebrafish embryos. Based on the gas chromatography-mass spectrometry analysis, the suspected active compounds that play a role in the toxicity were epicurzerenone, curzerene, and curzerenone, while 2,4,6-trimethylacetophenone was the predominant compound.

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Rekan penulisOrganisasiArtikel bersama
Wahono Esthi PrasetyaningtyasIPB University2
I Ketut Mudite AdnyaneIPB University2
Yanti SulistyanaIPB University2
Aryani Sismin SatyaningtijasIPB University1
Elsi RahmadhaniIPB University1
Damiana Rita EkastutiIPB University1
Ronald TariganIPB University1
Iman SupriatnaIPB University1
Ita DjuwitaIPB University1
NurbariahIPB University1
Arindina MahendraIPB University1
Aryani SatyaningtijasIPB University1
Elsi RahmadhaniIPB University1
Ronald TariganIPB University1
Damiana Rita EkastutiIPB University1
I Ketut Mudite AdnyaneIPB University1
Arinana ArinanaIPB University1
Irmanida BatubaraIPB University1
Auliya IlmiawatiIPB University1
Ummahatul MujahidahIPB University1
Shabrina ShabrinaIPB University1
Sri MulijaniIPB University1
Komar SutriahIPB University1
Friselsa PardedeIPB University1
Nindya Anandaputri RahardiAfiliasi tidak diketahui1
Syafri EdwarAfiliasi tidak diketahui1
Nurhidayat NurhidayatIPB University1
Mokhamad FahrudinIPB University1
Arief BoedionoIPB University1
Harry MurtiAfiliasi tidak diketahui1
Adrian SitumeangUniversity of Indonesia1
Handina RakhmawatiIPB University1
Andri Maruli Tua LubisUniversity of Indonesia1

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/JMV/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Acute Toxicity of Ethanol Extract of Curcuma zedoaria Rosc (Zingiberaceae) Rhizomes on Brine Shrimp Larvae and Zebrafish Embryos</dc:title>
	<dc:creator>Syahbirin, Gustini</dc:creator>
	<dc:creator>Aditianingrum, Kurnia Alysia</dc:creator>
	<dc:creator>Mohamad, Kusdiantoro</dc:creator>
	<dc:subject xml:lang="en-US">acute toxicity</dc:subject>
	<dc:subject xml:lang="en-US">Artemia salina</dc:subject>
	<dc:subject xml:lang="en-US">Curcuma zedoaria</dc:subject>
	<dc:subject xml:lang="en-US">Danio rerio</dc:subject>
	<dc:subject xml:lang="en-US">LC50</dc:subject>
	<dc:description xml:lang="en-US">Curcuma zedoaria Rosc (Zingiberaceae), known as white turmeric or temu putih, is commonly used as traditional medicine in Indonesia. The toxicity of this herb needs to be studied to improve its application. This study aimed to evaluate the toxicity of the crude ethanol extract of temu putih rhizome against brine shrimp (Artemia salina) larvae and zebrafish (Danio rerio) embryos and to analyze the potential active compounds contained in the extract. The crude ethanol extract showed a 50% lethal concentration value (LC50) at 588 ppm against brine shrimp larvae and 224 ppm against zebrafish embryos. Based on the gas chromatography-mass spectrometry analysis, the suspected active compounds that play a role in the toxicity were epicurzerenone, curzerene, and curzerenone, while 2,4,6-trimethylacetophenone was the predominant compound.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Airlangga</dc:publisher>
	<dc:date>2024-04-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/JMV/article/view/50071</dc:identifier>
	<dc:identifier>10.20473/jmv.vol7.iss1.2024.7-18</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Medik Veteriner; Vol. 7 No. 1 (2024): April; 7-18</dc:source>
	<dc:source>2581-012X</dc:source>
	<dc:source>2615-7497</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/JMV/article/view/50071/28252</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2024 Gustini Syahbirin, Kurnia Alysia Aditianingrum, Kusdiantoro Mohamad</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
</oai_dc:dc>