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Evaluation and Its Impact of SARS-CoV-2 Inactivated Vaccine Candidate in K18-hACE2 Mice

Jurnal Medik Veteriner · Vol. 8 No. 1 (2025) · hlm. 54–62

DOI
10.20473/jmv.vol8.iss1.2025.54-62
ISSN
2581-012X, 2615-7497
Terbit
2025-04-01
Penerbit
Universitas Airlangga
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-sa/4.0

Abstrak

The COVID-19 pandemic caused by SARS-CoV-2 requires effective vaccines to be developed. This study aimed to assess the impact of a SARS-CoV-2 inactivated vaccine candidate in k18-hACE2 mice by monitoring their body weight, immune activation, and inflammatory cytokines including IL-4, IL-6, TNF-α, and IFN-γ. The study utilized k18-hACE2 mice expressing the human angiotensin-converting enzyme 2 (hACE2) receptor. The mice were administered the inactivated vaccine candidate compared with sham and vehicle. Body weight was monitored, and serum samples were collected to measure IL-4, IL-6, TNF-α, and IFN-γ levels using ELISA. Data were evaluated using SPSS statistical analysis software. The administration of the SARS-CoV-2 inactivated vaccine candidate in k18-hACE2 mice did not result in significant changes in body weight compared to the control group. Furthermore, the levels of IL-4, IL-6, TNF-α, and IFN-γ were significantly reduced in the vaccinated mice compared to the control group, suggesting a dampening effect on the inflammatory response. This study demonstrates that the SARS-CoV-2 inactivated vaccine candidate has a minimal impact on the body weight of k18-hACE2 mice. Nevertheless, it successfully regulates the levels of IL-4, IL-6, TNF-α, and IFN-γ, suggesting its safety and beneficial impact. These findings contribute to understanding the vaccine's efficacy and safety profile in vaccine development.

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  • Institut Teknologi Medan
  • Universitas Pendidikan Ganesha
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Tampilkan sebagai tabel
Rekan penulisOrganisasiArtikel bersama
Suwarno SuwarnoInstitut Teknologi Medan13
Nusdianto TriakosoAfiliasi tidak diketahui10
Prima Ayu WibawatiAfiliasi tidak diketahui8
Maya Nurwartanti YunitaAfiliasi tidak diketahui7
Amung Logam SaputroAfiliasi tidak diketahui7
Ratih Novita PrajaAfiliasi tidak diketahui6
Wiwiek TyasningsihAfiliasi tidak diketahui6
Aswin Rafif KhairullahAfiliasi tidak diketahui6
Aditya YudhanaAfiliasi tidak diketahui5
Iwan Sahrial HamidAfiliasi tidak diketahui5
Kusnoto KusnotoAfiliasi tidak diketahui5
Mufasirin MufasirinAfiliasi tidak diketahui4
Muchammad YunusAfiliasi tidak diketahui4
Eduardus Bimo AksonoAfiliasi tidak diketahui4
Thomas Valentinus WidiyatnoAfiliasi tidak diketahui4
Endang SuprihatiAfiliasi tidak diketahui3
Mohammad Anam Al ArifAfiliasi tidak diketahui3
RoziAfiliasi tidak diketahui3
Putri Desi Wulan SariAfiliasi tidak diketahui3
Annas SallehAfiliasi tidak diketahui3
Bodhi AgustonoAfiliasi tidak diketahui3
Hardany PrimarizkyAfiliasi tidak diketahui3
Ratna DamayantiAfiliasi tidak diketahui3
I Ketut SudianaUniversitas Pendidikan Ganesha2
Eko Agus SuyonoAfiliasi tidak diketahui2
Arief BudimanAfiliasi tidak diketahui2
Ulfah Juniarti SiregarAfiliasi tidak diketahui2
Heni PuspitasariAfiliasi tidak diketahui2

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/JMV/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">Evaluation and Its Impact of SARS-CoV-2 Inactivated Vaccine Candidate in K18-hACE2 Mice</dc:title>
	<dc:creator>A'la, Rofiqul</dc:creator>
	<dc:creator>Rantam, Fedik Abdul</dc:creator>
	<dc:creator>Wijaya, Andi Yasmin</dc:creator>
	<dc:creator>Susilowati, Helen</dc:creator>
	<dc:creator>Kuncorojakti, Suryo</dc:creator>
	<dc:creator>Diyantoro, Diyantoro</dc:creator>
	<dc:creator>Aswin, Ahmad</dc:creator>
	<dc:creator>Rahmahani, Jola</dc:creator>
	<dc:creator>Suwanti, Lucia Tri</dc:creator>
	<dc:creator>Lukiswanto, Bambang Sektiari</dc:creator>
	<dc:creator>Yudaniayanti, Ira Sari</dc:creator>
	<dc:creator>Setiawan, Boedi</dc:creator>
	<dc:subject xml:lang="en-US">COVID-19</dc:subject>
	<dc:subject xml:lang="en-US">K18-hACE2</dc:subject>
	<dc:subject xml:lang="en-US">SARS-CoV-2</dc:subject>
	<dc:subject xml:lang="en-US">transgenic</dc:subject>
	<dc:subject xml:lang="en-US">vaccination</dc:subject>
	<dc:description xml:lang="en-US">The COVID-19 pandemic caused by SARS-CoV-2 requires effective vaccines to be developed. This study aimed to assess the impact of a SARS-CoV-2 inactivated vaccine candidate in k18-hACE2 mice by monitoring their body weight, immune activation, and inflammatory cytokines including IL-4, IL-6, TNF-α, and IFN-γ. The study utilized k18-hACE2 mice expressing the human angiotensin-converting enzyme 2 (hACE2) receptor. The mice were administered the inactivated vaccine candidate compared with sham and vehicle. Body weight was monitored, and serum samples were collected to measure IL-4, IL-6, TNF-α, and IFN-γ levels using ELISA. Data were evaluated using SPSS statistical analysis software. The administration of the SARS-CoV-2 inactivated vaccine candidate in k18-hACE2 mice did not result in significant changes in body weight compared to the control group. Furthermore, the levels of IL-4, IL-6, TNF-α, and IFN-γ were significantly reduced in the vaccinated mice compared to the control group, suggesting a dampening effect on the inflammatory response. This study demonstrates that the SARS-CoV-2 inactivated vaccine candidate has a minimal impact on the body weight of k18-hACE2 mice. Nevertheless, it successfully regulates the levels of IL-4, IL-6, TNF-α, and IFN-γ, suggesting its safety and beneficial impact. These findings contribute to understanding the vaccine's efficacy and safety profile in vaccine development.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Airlangga</dc:publisher>
	<dc:date>2025-04-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/JMV/article/view/59552</dc:identifier>
	<dc:identifier>10.20473/jmv.vol8.iss1.2025.54-62</dc:identifier>
	<dc:source xml:lang="en-US">Jurnal Medik Veteriner; Vol. 8 No. 1 (2025): April; 54-62</dc:source>
	<dc:source>2581-012X</dc:source>
	<dc:source>2615-7497</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/JMV/article/view/59552/32224</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 Rofiqul A'la, Fedik Abdul Rantam, Andi Yasmin Wijaya, Helen Susilowati, Suryo Kuncorojakti, Diyantoro Diyantoro, Ahmad Aswin, Jola Rahmahani, Lucia Tri Suwanti, Bambang Sektiari Lukiswanto, Ira Sari Yudaniayanti, Boedi Setiawan</dc:rights>
	<dc:rights xml:lang="en-US">http://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
</oai_dc:dc>