Jurnal SINTA 1
The Effect of Orlistat, Green Coffee Bean Extract, and Its Combinations on Lipid Profi le and Adiponectin Levels
Jurnal Ners · Vol. 9 No. 1 (2017) · hlm. 26–34
- ISSN
- 2502-5791, 1858-3598
- Terbit
- 2017-01-27
- Penerbit
- Universitas Airlangga
- Bahasa
- eng
Abstrak
Introduction: Obesity prevalence is estimated increases, reached 19.1% of the population aged 15 years and over. This study aimed to determine the differences of the anti- obesity effect of orlistat, an extract of green coffee beans (Coffea canephora robusta), and its combination to the adiponectin levels and lipid profile.Method: This research was true experimental post -test only with control group design with completely randomized design (CRD). Experimental animals (Rattus novergicus) were divided into 6 group, group 1 ( negative control ), group 2 ( positive control ), group 3 was group of obese rats fed orlistat dose of 15.9 mg/kg, group 4 was the group of obese rats were fed ethanol extract of green coffee beans dose of 400 mg/kg, group 5 was the group of obese rats were given water extract of green coffee beans dose of 400 mg/kg, and group 6 was group of obese rats were fed a combination of orlistat dose of 15.9 mg/kg and ethanol extract of green coffee beans at a dose of 400 mg/kg. Lipid profi les and adiponectin levels were measured with a spectrophotometer at 500nm absorbance. The data were analyzed by one-way ANOVA, and then post hoc Least Significant Difference (LSD) with α = 0.05.Results: Ethanol extract of green coffee is more effi cient in lowering LDL cholesterol, increasing HDL cholesterol, and lowering the total cholesterol levels on HFD diet-induced mice, but there was no difference in lowering triglycerides. The combination of ethanol extract of green coffee with orlistat showedthe increasing of adiponectin levels were highest than the other treatment groups.Conclusion: The ethanol extract of green coffee readily diffuses through the digestive tract epithelium. Green coffee contains chlorogenic acid active compounds that can increase the body's metabolism, increase fatty acid oxidation, reduce levels of triglycerides in the liver, and working to inhibit lipase and amylase pancreaticenzymes. In addition to chlorogenic acid, polyphenol content in coffee is also potentially reduce visceral fat accumulation. Preparations extract by ethanol allows the absorption process is done effi ciently and quickly.
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- Sunan Kalijaga State Islamic University Yogyakarta
- Universitas Gadjah Mada
- Tadulako University
- University of Indonesia
- Sebelas Maret University
- Universitas Muhammadiyah Semarang
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- Organisasi berbeda
- Organisasi sama
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| Rekan penulis | Organisasi | Artikel bersama |
|---|---|---|
| Hisam Ahyani | Afiliasi tidak diketahui | 2 |
| Haris Maiza Putra | Afiliasi tidak diketahui | 2 |
| Komarudin Komarudin | University of Indonesia | 2 |
| Ardhi Ardhi | Sunan Kalijaga State Islamic University Yogyakarta | 1 |
| Danny Syamsu W | Afiliasi tidak diketahui | 1 |
| Andi Idhan Muchsin | Afiliasi tidak diketahui | 1 |
| Siti Komariyah | Afiliasi tidak diketahui | 1 |
| Lilis Yuliati | Afiliasi tidak diketahui | 1 |
| Nely Supeni | Afiliasi tidak diketahui | 1 |
| Ahmad Mahfudzi Mafrudlo | Afiliasi tidak diketahui | 1 |
| Zuhratul Aini Mansur | Afiliasi tidak diketahui | 1 |
| Yadi Janwari | Afiliasi tidak diketahui | 1 |
| Muharir Muharir | Afiliasi tidak diketahui | 1 |
| Encep Taufik Rahman | Afiliasi tidak diketahui | 1 |
| Iwan Mulyana | Afiliasi tidak diketahui | 1 |
| Dewi Sadiah | Afiliasi tidak diketahui | 1 |
| Doddy Afandi Firdaus | Afiliasi tidak diketahui | 1 |
| Arwansyah bin Kirin | Afiliasi tidak diketahui | 1 |
| Zakiyyu Muhammad | Afiliasi tidak diketahui | 1 |
| Catur Sugiyanto | Universitas Gadjah Mada | 1 |
| Akhmad Akbar Susamto | Afiliasi tidak diketahui | 1 |
| José V García-Jiménez | Afiliasi tidak diketahui | 1 |
| Ranintya Meikahani | Afiliasi tidak diketahui | 1 |
| Ari Iswanto | Afiliasi tidak diketahui | 1 |
| Satya Perdana | Afiliasi tidak diketahui | 1 |
| Galih Pamungkas | Afiliasi tidak diketahui | 1 |
| Joko Nurkamto | Sebelas Maret University | 1 |
| M. Furqon Hidayatullah | Afiliasi tidak diketahui | 1 |
| Sitarina Widyarini | Afiliasi tidak diketahui | 1 |
| Eti Nurwening Sholikhah | Afiliasi tidak diketahui | 1 |
| Jumina Jumina | Afiliasi tidak diketahui | 1 |
| Ruslin Hadanu | Afiliasi tidak diketahui | 1 |
| Tri Wibawa | Universitas Gadjah Mada | 1 |
| Maya Dian Rakhmawatie | Universitas Muhammadiyah Semarang | 1 |
| Puspita Lisdiyanti | Afiliasi tidak diketahui | 1 |
| Kanti Ratnaningrum | Afiliasi tidak diketahui | 1 |
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