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Imunomodulator Activity of Alginate Oligosaccharides from Alginate Sargassum crassifolium

Jurnal Pengolahan Hasil Perikanan Indonesia · Vol. 20 No. 1 (2017) · hlm. 63–73

DOI
10.17844/jphpi.v20i1.16434
ISSN
2354-886X, 2303-2111
Terbit
2017-04-25
Penerbit
Department of Aquatic Product Technology IPB University in collaboration with Masyarakat Pengolahan Hasil Perikanan Indonesia (MPHPI)
Bahasa
eng

Abstrak

Alginate oligosaccharides (AOS) are oligosaccharides produced from depolimerization of the alginate polymer, and is reported to have various biological activities. The study aims is to determine the effect of AOSproduction conditions and their effects on products and its activities as an immunomodulatory compound. Production of alginate oligosaccharides (AOS) enzymatically carried out with the help of alginate lyase enzyme produced from the bacterium Bacillus megaterium S245. Variation of incubation time is 2, 4, 6 and 8 hours at concentrations of alginate lyase enzyme addition of 25, 50, 75 and 100U. Treatment of enzyme concentration and the duration of incubation in the production of AOS produces a degree of polymerization (DP) 2-7. In vitro activity test showed AOS is have ability to induce cell proliferation of human lymphocytes.This type of cell lymphocytes proliferation induced by AOS is a CD 8 cells or cytotoxic T cell and non cell CD4 / CD8. AOS production conditions with the addition of alginate lyase enzyme 50 U and incubation period 2 hours has produce AOS with the highest index of lymphocyte proliferation 117.6+3.6% or an increase of 43.24% compared to the native alginat polymer.

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  • Politeknik Negeri Ujung Pandang
  • University of Bengkulu
  • IPB University
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ALBERTA RIKA PRATIWIAfiliasi tidak diketahui2
DAHRUL SYAHAfiliasi tidak diketahui2
Agus PurwantoAfiliasi tidak diketahui1
Hery WinarsiAfiliasi tidak diketahui1
DEDDY MUCHTADIAfiliasi tidak diketahui1
Tati NurhayatiAfiliasi tidak diketahui1
LILIS NURAIDAAfiliasi tidak diketahui1
SRI BUDIARTI POERWANTOAfiliasi tidak diketahui1
AGNES IMELDA MANURUNGAfiliasi tidak diketahui1
Linawati HardjitoAfiliasi tidak diketahui1
LILY MARIA GORETTI PANGGABEANAfiliasi tidak diketahui1
Diana Nur AfifahAfiliasi tidak diketahui1
Raymond Rubianto TjandrawinataAfiliasi tidak diketahui1
Laurentia StephaniAfiliasi tidak diketahui1
Yanti LimAfiliasi tidak diketahui1
Wangsa Tirta IsmayaAfiliasi tidak diketahui1
S. SipriyadiUniversity of Bengkulu1
Aris Tri WahyudiIPB University1
Anja MeryandiniAfiliasi tidak diketahui1
Erniati ErniatiAfiliasi tidak diketahui1
Endang PrangdimurtiAfiliasi tidak diketahui1
Dede Robiatul AdawiyahAfiliasi tidak diketahui1
Nurhayati NurhayatiPoliteknik Negeri Ujung Pandang1
nurjanah nurjanahAfiliasi tidak diketahui1
Agus SupriyantoAfiliasi tidak diketahui1
Sihono SihonoAfiliasi tidak diketahui1
Bagus Sediadi Bandol UtomoAfiliasi tidak diketahui1
Wahyu RamadhanAfiliasi tidak diketahui1
Ellya SinuratAfiliasi tidak diketahui1
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Theresia Dwi SuryaningrumAfiliasi tidak diketahui1
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Bakti Berlyanto SedayuAfiliasi tidak diketahui1
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Sumber metadata: OAI-PMH (metadata jurnal) http://journal.ipb.ac.id/index.php/jphpi/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en">Imunomodulator Activity of Alginate Oligosaccharides from Alginate Sargassum crassifolium</dc:title>
	<dc:creator xml:lang="en">Subaryono, Subaryono</dc:creator>
	<dc:creator xml:lang="en">Perangiangin, Rosmawati</dc:creator>
	<dc:creator xml:lang="en">Suhartono, Maggy Thenawidjaja</dc:creator>
	<dc:creator xml:lang="en">Zakaria, Fransiska Rungkat</dc:creator>
	<dc:subject xml:lang="en">Bacillus megaterium S245</dc:subject>
	<dc:subject xml:lang="en">lymphocyte proliferation</dc:subject>
	<dc:subject xml:lang="en">seaweed</dc:subject>
	<dc:subject xml:lang="en">cytotoxic</dc:subject>
	<dc:description xml:lang="en">Alginate oligosaccharides (AOS) are oligosaccharides produced from depolimerization of the alginate polymer, and is reported to have various biological activities. The study aims is to determine the effect of AOSproduction conditions and their effects on products and its activities as an immunomodulatory compound. Production of alginate oligosaccharides (AOS) enzymatically carried out with the help of alginate lyase enzyme produced from the bacterium Bacillus megaterium S245. Variation of incubation time is 2, 4, 6 and 8 hours at concentrations of alginate lyase enzyme addition of 25, 50, 75 and 100U. Treatment of enzyme concentration and the duration of incubation in the production of AOS produces a degree of polymerization (DP) 2-7. In vitro activity test showed AOS is have ability to induce cell proliferation of human lymphocytes.This type of cell lymphocytes proliferation induced by AOS is a CD 8 cells or cytotoxic T cell and non cell CD4 / CD8. AOS production conditions with the addition of alginate lyase enzyme 50 U and incubation period 2 hours has produce AOS with the highest index of lymphocyte proliferation  117.6+3.6% or an increase of 43.24% compared to the native alginat polymer.</dc:description>
	<dc:publisher xml:lang="en">Department of Aquatic Product Technology IPB University in collaboration with Masyarakat Pengolahan Hasil Perikanan Indonesia (MPHPI)</dc:publisher>
	<dc:date>2017-04-25</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://journal.ipb.ac.id/jphpi/article/view/16434</dc:identifier>
	<dc:identifier>10.17844/jphpi.v20i1.16434</dc:identifier>
	<dc:source xml:lang="id">Jurnal Pengolahan Hasil Perikanan Indonesia; Vol 20 No 1 (2017): Jurnal Pengolahan Hasil Perikanan Indonesia; 63-73</dc:source>
	<dc:source xml:lang="en">Jurnal Pengolahan Hasil Perikanan Indonesia; Vol. 20 No. 1 (2017): Jurnal Pengolahan Hasil Perikanan Indonesia; 63-73</dc:source>
	<dc:source>2354-886X</dc:source>
	<dc:source>2303-2111</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://journal.ipb.ac.id/jphpi/article/view/16434/12603</dc:relation>
	<dc:rights xml:lang="en">Copyright (c) 2017 Jurnal Pengolahan Hasil Perikanan Indonesia</dc:rights>
</oai_dc:dc>