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Preparation and characterization of nanopowder of Acalypha hispida Leaves Extract Using Planetary Ball Milling

Molekul: Jurnal Ilmiah Kimia · Vol. 17 No. 1 (2022) · hlm. 68–75

DOI
10.20884/1.jm.2022.17.1.5601
ISSN
2503-0310, 1907-9761
Terbit
2022-03-13
Penerbit
Universitas Jenderal Soedirman
Bahasa
eng

Abstrak

Acalypha hispida Burm.f. is commonly used as an ornamental plant known for pharmacological effects. The nanoscale extract increases bioavailability and bioactivity. This research aimed to produce and characterize nanopowder extract of A. hispida leaves. Powdered leaves were macerated in 96% ethanol, then was evaporated in the spry dryer. Nanopowder extract was produced using planetary ball milling at 5000 rpm in different milling times, namely 5 minutes (nanopowder A), 10 minutes (nanopowder B), and 40 minutes (nanopowder C). The nanopowder extracts were evaluated using a particle size analyzer, scanning electron microscope, and high-performance liquid chromatography. The average particle size of A. hispida crude extract was 1271 nm, and nanopowder A, B, and C respectively were 837.1 nm, 803.8, and 512.2 nm. The polydispersity index of A. hispida crude extract, nanopowder A, B, and C were 0.754, 0.696, 0.717, dan 0.612. The milling process for 40 minutes reduced the content of 5% gallic acid and 10.3% catechin. The SEM image of nanopowder C was smaller than crude extract. The best average particle size of nanopowder C (512.2 nm) and polydispersity index (0.612) were produced using PBM for 40 minutes at 5000 rpm.

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  • IPB University
  • The University of Osaka
  • Tadulako University
  • Universitas Gadjah Mada
  • Kementerian Kesehatan Republik Indonesia
  • Universitas Syiah Kuala
  • Indonesian Oil Palm Research Institute
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Rekan penulisOrganisasiArtikel bersama
Made AstawanIPB University6
Arief BoedionoIPB University3
Rika RaffiudinIPB University3
Tri AtmowidiIPB University2
Fahri FahriTadulako University2
Nisfia Rakhmatun NisaIPB University2
Windra PriawandiputraIPB University2
Deddy MuchtadiIPB University2
VENNY FEBRIYANIAfiliasi tidak diketahui2
Adi WinartoIPB University2
Saraswati SaraswatiIPB University1
Ayu Putri Gitanjali PrayudaniIPB University1
Nabila Az Zahra YalmaidaIPB University1
Aprilia Firdha DamayantiAfiliasi tidak diketahui1
Ans Budi HartantaIPB University1
Teguh Suranta SinulinggaIPB University1
Yoli ZulfanediIPB University1
Sastia Prama PutriThe University of Osaka1
Eiichiro FukusakiThe University of Osaka1
Inas Suci RahmawatiIPB University1
Ananda Putri CahyaniIPB University1
Mokhamad FahrudinIPB University1
Vista BudiariatiUniversitas Gadjah Mada1
Dwi BudionoIPB University1
Ratih RinendyaputriKementerian Kesehatan Republik Indonesia1
Alamsah FirdausIPB University1
Araz MeilinNational Research and Innovation Agency1
Windra PriawandiputraAfiliasi tidak diketahui1
Jasmi JasmiAfiliasi tidak diketahui1
Yulia PujiastutiSriwijaya University1
Jauharlina JauharlinaUniversitas Syiah Kuala1
Mahardika Gama PradanaIndonesian Oil Palm Research Institute1
Puji LestariLampung University1
Innayah ZaharaIPB University1
Jacobus S. A. LamerkabelUniversitas Pattimura1
Qashiratuttarafi QashiratuttarafiAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jos.unsoed.ac.id/index.php/jm/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US"> Preparation and characterization of nanopowder of Acalypha hispida Leaves Extract Using Planetary Ball Milling</dc:title>
	<dc:creator>Alfarisi, Hamzah</dc:creator>
	<dc:creator>Sa'diah, Siti</dc:creator>
	<dc:creator>Juliandi, Berry</dc:creator>
	<dc:creator>Wresdiyati, Tutik</dc:creator>
	<dc:description xml:lang="en-US">Acalypha hispida Burm.f. is commonly used as an ornamental plant known for pharmacological effects. The nanoscale extract increases bioavailability and bioactivity. This research aimed to produce and characterize nanopowder extract of A. hispida leaves. Powdered leaves were macerated in 96% ethanol, then was evaporated in the spry dryer. Nanopowder extract was produced using planetary ball milling at 5000 rpm in different milling times, namely 5 minutes (nanopowder A), 10 minutes (nanopowder B), and 40 minutes (nanopowder C). The nanopowder extracts were evaluated using a particle size analyzer, scanning electron microscope, and high-performance liquid chromatography. The average particle size of A. hispida crude extract was 1271 nm, and nanopowder A, B, and C respectively were 837.1 nm, 803.8, and 512.2 nm. The polydispersity index of A. hispida crude extract, nanopowder A, B, and C were 0.754, 0.696, 0.717, dan 0.612. The milling process for 40 minutes reduced the content of 5% gallic acid and 10.3% catechin. The SEM image of nanopowder C was smaller than crude extract. The best average particle size of nanopowder C (512.2 nm) and polydispersity index (0.612) were produced using PBM for 40 minutes at 5000 rpm.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Jenderal Soedirman</dc:publisher>
	<dc:date>2022-03-13</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
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	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jos.unsoed.ac.id/index.php/jm/article/view/5601</dc:identifier>
	<dc:identifier>10.20884/1.jm.2022.17.1.5601</dc:identifier>
	<dc:source xml:lang="en-US">Molekul; Vol 17 No 1 (2022); 68-75</dc:source>
	<dc:source>2503-0310</dc:source>
	<dc:source>1907-9761</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jos.unsoed.ac.id/index.php/jm/article/view/5601/2818</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Molekul</dc:rights>
	<dc:rights xml:lang="en-US">http://jos.unsoed.ac.id/index.php/jm/index</dc:rights>
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