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Synthesis and Antibacterial Activity of N-phenyl-3-(4-chlorophenyl)-5-(3,4-dimethoxy-phenyl) pyrazoline

Molekul: Jurnal Ilmiah Kimia · Vol. 20 No. 2 (2025) · hlm. 197–202

DOI
10.20884/1.jm.2025.20.2.5618
ISSN
2503-0310, 1907-9761
Terbit
2025-07-24
Penerbit
Universitas Jenderal Soedirman
Bahasa
eng

Abstrak

ABSTRACT. Compound of N-phenyl-3-(4-chlorophenyl)-5-(3,4-dimethoxy-phenyl) pyrazoline was synthesized by cycloaddition reaction. The structure of the product was chracterized by FTIR, 1H-NMR and 13C-NMR spectrometers. The pyrazoline was screened for antibacterial activity using agar diffusion method against Staphylococcus aureus, Bacillus cereus, Bacillus subtillis, Shigella flexnerri, and Escherichia coli. The pyrazoline had been synthesized from chalcone with phenylhydrazine to give 52.90% yield. Antibacterial screening showed that pyrazoline was active against selected gram positive bacteria. The pyrazoline was found to exhibits an antibacterial activity and its zone of inhibition/concentration against S. aureus (8.75/300), B. cereus (7.75/1000), B. subtillis (6.50/1000), and E. coli (3.50/300). The result showed that pyrazoline which was subtituted with chloro and methoxy, was able to posse broad spectrum of the tested pathogenic bacteria. Keywords: chalcone, pyrazoline, antibacterial

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  • Universitas Gadjah Mada
  • Universitas Bakti Tunas Husada
  • State University of Semarang
  • IPB University
  • Universitas Jember
  • State University of Medan
  • Politeknik ATK Yogyakarta
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Rekan penulisOrganisasiArtikel bersama
Tri Joko RaharjoState University of Semarang2
Putra Jiwamurwa Pama TjitdaAfiliasi tidak diketahui1
Febri Odel NitbaniAfiliasi tidak diketahui1
Widodo WidodoIPB University1
Tiyas Tono TaufiqAfiliasi tidak diketahui1
Nosa Septiana AninditaAfiliasi tidak diketahui1
Dwi SiswantaUniversitas Gadjah Mada1
Busroni BusroniUniversitas Jember1
Sri Juari SantosaUniversitas Gadjah Mada1
Jumina JuminaUniversitas Gadjah Mada1
Zehan AndrianaUniversitas Gadjah Mada1
Gatut Ari WardaniUniversitas Bakti Tunas Husada1
Mia NurhidahUniversitas Bakti Tunas Husada1
Winda Trisna WulandariUniversitas Bakti Tunas Husada1
Ricky Andi SyahputraState University of Medan1
Indra IndraUniversitas Bakti Tunas Husada1
Sabirin MatsjehUniversitas Ahmad Dahlan1
Wisnu PambudiPoliteknik ATK Yogyakarta1
Winarto HaryadiUniversitas Gadjah Mada1
Yehezkiel Steven KurniawanUniversitas Gadjah Mada1
Jumina JuminaUniversitas Gadjah Mada1
Putri Dian AnggraeniUniversitas Gadjah Mada1
Endang AstutiUniversitas Gadjah Mada1
Muhammad Idham Darussalam MardjanUniversitas Gadjah Mada1
Widya RahmawatiUniversitas Gadjah Mada1
Rahmawati SulistyaUniversitas Gadjah Mada1
Ircham Nur ChabibUniversitas Gadjah Mada1
Tri Muji SusantoroNational Research and Innovation Agency1
Rofy Anugrah DesrinaAfiliasi tidak diketahui1
Triyono TriyonoUniversitas Gadjah Mada1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jos.unsoed.ac.id/index.php/jm/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US"> Synthesis and Antibacterial Activity of N-phenyl-3-(4-chlorophenyl)-5-(3,4-dimethoxy-phenyl) pyrazoline</dc:title>
	<dc:creator>Nofiyanti, Estin</dc:creator>
	<dc:creator>Wahyuningsih, Tutik Dwi</dc:creator>
	<dc:creator>BTAG, Noer Laelly</dc:creator>
	<dc:creator>Anwar, Chairil</dc:creator>
	<dc:creator>Nurjanah, Novi</dc:creator>
	<dc:creator>Salman, Nurcholis</dc:creator>
	<dc:creator>Priastomo, Yoga</dc:creator>
	<dc:description xml:lang="en-US">ABSTRACT. Compound of N-phenyl-3-(4-chlorophenyl)-5-(3,4-dimethoxy-phenyl) pyrazoline was synthesized by cycloaddition reaction. The structure of the product was chracterized by FTIR,&amp;nbsp; 1H-NMR and 13C-NMR spectrometers.&amp;nbsp; The pyrazoline was screened for antibacterial activity using agar diffusion method against Staphylococcus aureus, Bacillus cereus, Bacillus subtillis, Shigella flexnerri, and Escherichia coli. The pyrazoline had been synthesized from chalcone with phenylhydrazine to give 52.90% yield. Antibacterial screening showed that pyrazoline was active against selected gram positive bacteria. The pyrazoline was found to exhibits an antibacterial activity and its zone of inhibition/concentration against S. aureus (8.75/300), B. cereus (7.75/1000), B. subtillis (6.50/1000), and E. coli (3.50/300). The result showed that pyrazoline which was subtituted with chloro and methoxy, was able to posse broad spectrum of the tested pathogenic bacteria.
&amp;nbsp;
Keywords: chalcone, pyrazoline, antibacterial</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Jenderal Soedirman</dc:publisher>
	<dc:date>2025-07-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jos.unsoed.ac.id/index.php/jm/article/view/5618</dc:identifier>
	<dc:identifier>10.20884/1.jm.2025.20.2.5618</dc:identifier>
	<dc:source xml:lang="en-US">Molekul; Vol 20 No 2 (2025); 197-202</dc:source>
	<dc:source>2503-0310</dc:source>
	<dc:source>1907-9761</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jos.unsoed.ac.id/index.php/jm/article/view/5618/7151</dc:relation>
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