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Anti-inflammatory and immunosuppressant activity of Coprinus comatus ethanol extract in carrageenan-induced rats (Rattus norvegicus)

Molekul: Jurnal Ilmiah Kimia · Vol. 17 No. 3 (2022) · hlm. 335–345

DOI
10.20884/1.jm.2022.17.3.5815
ISSN
2503-0310, 1907-9761
Terbit
2022-11-19
Penerbit
Universitas Jenderal Soedirman
Bahasa
eng

Abstrak

oprinus comatus (O.F. Mull.) is an edible mushroom that is used as an anti-inflammatory agent. Therefore, this study aims to determine the effect of inflammation treatment on symptoms alleviating, function maintenance, and inhibiting the process of tissue damage due to an increase in free radicals using drug formulations with high antioxidant compounds. This is a true experiment conducted using a Completely Randomized Design (CRD) with a post-test and a control group. The rats were divided into 6 categories, which include 1 healthy and 5 groups induced with 1% carrageenan. Out of the treatment groups, 3 were treated with ethanol extract of C. comatus fruiting body at doses of 250 (T1), 500 (T2), and 750 mg/kg BW (T3), 1 received diclofenac sodium (PC) and the other as a negative control (NC), were given extract for 14 days and induced with 0.5 mL carrageenan in paw of rats at day 15. The qualitative identification showed the extracts contains flavonoid, polyphenol, alkaloid, triterpenoid, steroids and saponins, and GC-MS analysis showed 10 putative metabolites compound. T2 group significantly decreased the levels of IL-1β (70.63%), IgE (59.04%), total leukocyte count (31.24%), plantar thickness (12.5%), edema volume (33.3%), and increased endothelial NO levels (48.2%).

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  • Jenderal Soedirman University
  • RSUD Prof. Dr. Margono Soekarjo
  • International Women University
  • Indonesian Institute of Sciences
  • Lambung Mangkurat University
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Rekan penulisOrganisasiArtikel bersama
Salamiah .Afiliasi tidak diketahui2
Witiyasti ImaningsihLambung Mangkurat University2
Loekas SoesantoJenderal Soedirman University2
Hameda Dhaka Kusuma TaufiqJenderal Soedirman University2
Warsinah WarsinahJenderal Soedirman University1
Triyadi Hendra WijayaJenderal Soedirman University1
Agus Hery SusantoJenderal Soedirman University1
Ana YuliaJenderal Soedirman University1
Hery WinarsiJenderal Soedirman University1
Agus PurwantoRSUD Prof. Dr. Margono Soekarjo1
Edi BasukiJenderal Soedirman University1
Achmad MunadjatJenderal Soedirman University1
Oedjijono OedjijonoJenderal Soedirman University1
Nanik RahmaniIndonesian Institute of Sciences1
Rina Dwi AgustianiInternational Women University1
Dody NovrialJenderal Soedirman University1
Alfi MuntafiahJenderal Soedirman University1
Johanes Hasian SiahaanJenderal Soedirman University1
Sofyan HardiJenderal Soedirman University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jos.unsoed.ac.id/index.php/jm/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US"> Anti-inflammatory and immunosuppressant activity of Coprinus comatus ethanol extract in carrageenan-induced rats (Rattus norvegicus)</dc:title>
	<dc:creator>Ratnaningtyas, Nuniek Ina</dc:creator>
	<dc:creator>Husen, Fajar</dc:creator>
	<dc:creator>Hernayanti, Hernayanti</dc:creator>
	<dc:creator>Ekowati, Nuraeni</dc:creator>
	<dc:creator>Budianto, Bambang Heru</dc:creator>
	<dc:description xml:lang="en-US">


oprinus comatus (O.F. Mull.) is an edible mushroom that is used as an anti-inflammatory agent. Therefore, this study aims to determine the effect of inflammation treatment on symptoms alleviating, function maintenance, and inhibiting the process of tissue damage due to an increase in free radicals using drug formulations with high antioxidant compounds. This is a true experiment conducted using a Completely Randomized Design (CRD) with a post-test and a control group. The rats were divided into 6 categories, which include 1 healthy and 5 groups induced with 1% carrageenan. Out of the treatment groups, 3 were treated with ethanol extract of C. comatus fruiting body at doses of 250 (T1), 500 (T2), and 750 mg/kg BW (T3), 1 received diclofenac sodium (PC) and the other as a negative control (NC), were given extract for 14 days and induced with 0.5 mL carrageenan in paw of rats at day 15. The qualitative identification showed the extracts contains flavonoid, polyphenol, alkaloid, triterpenoid, steroids and saponins, and GC-MS analysis showed 10 putative metabolites compound. T2 group significantly decreased the levels of IL-1β (70.63%), IgE (59.04%), total leukocyte count (31.24%), plantar thickness (12.5%), edema volume (33.3%), and increased endothelial NO levels (48.2%).


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	<dc:publisher xml:lang="en-US">Universitas Jenderal Soedirman</dc:publisher>
	<dc:date>2022-11-19</dc:date>
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	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jos.unsoed.ac.id/index.php/jm/article/view/5815</dc:identifier>
	<dc:identifier>10.20884/1.jm.2022.17.3.5815</dc:identifier>
	<dc:source xml:lang="en-US">Molekul; Vol 17 No 3 (2022); 335-345</dc:source>
	<dc:source>2503-0310</dc:source>
	<dc:source>1907-9761</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jos.unsoed.ac.id/index.php/jm/article/view/5815/3448</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Molekul</dc:rights>
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