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Detoxification of Cadmium on Albino Rats (Rattus norvegicus) with Natural Chelator of Fruiting Body Extract of Ganoderma lucidum

Molekul: Jurnal Ilmiah Kimia · Vol. 18 No. 1 (2023) · hlm. 21–28

DOI
10.20884/1.jm.2023.18.1.5844
ISSN
2503-0310, 1907-9761
Terbit
2023-03-20
Penerbit
Universitas Jenderal Soedirman
Bahasa
eng

Abstrak

Cadmium is a heavy metal pollutant sourced from various industries and toxic to the kidneys. Cadmium exposure can be used natural chelator of ethanol extract of the fruiting body of Ganoderma lucidum. The aim of the study was to determine the effect and effective dose of the ethanolic extract of the fruiting body of G. lucidum on reducing the toxicity effect of cadmium in male albino rats (Rattus norvegicus) Wistar strain. The research design was experimental research, which consisted of 5 treatment levels. The research parameters were blood cadmium, β2-microglobulin, malondialdehyde, and superoxide dismutase levels. The ethanolic extract of fruiting body of G. lucidum was tested by gas chromatography-mass spectrometry (GCMS) to determine linalool as active compounds. The results of each parameter had a significant effect, which decreased blood cadmium, β2M and MDA levels, and increased SOD level that linear according to the addition of the dose of ethanol extract of the fruiting body of G. lucidum. Blood cadmium levels with β2M and MDA levels had a positive correlation, while blood cadmium levels with SOD levels had a negative correlation. The dominant compound detected was linalool which has potential as a radical scavenger. The dose of 750 mg.kgBW-1 is the effective dose of the ethanolic extract of fruiting body of G. lucidum based on a decrease in blood cadmium levels (54.10%), β2M (63.94%) and MDA (20.31%), as well as an increase in SOD levels (14.20%) compared to sick control.

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  • Jenderal Soedirman University
  • Lambung Mangkurat University
  • RSUD Prof. Dr. Margono Soekarjo
  • University of Bengkulu
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Rekan penulisOrganisasiArtikel bersama
Nuraeni EkowatiJenderal Soedirman University3
Bambang Heru BudiantoJenderal Soedirman University2
Fajar HusenAfiliasi tidak diketahui2
Agus Hery SusantoJenderal Soedirman University1
Ana YuliaJenderal Soedirman University1
Hery WinarsiJenderal Soedirman University1
Agus PurwantoRSUD Prof. Dr. Margono Soekarjo1
Salamiah .Afiliasi tidak diketahui1
Witiyasti ImaningsihLambung Mangkurat University1
Loekas SoesantoJenderal Soedirman University1
Suhendra SuhendraUniversity of Bengkulu1
Anni NurlianiLambung Mangkurat University1
Rakmawati RakmawatiLambung Mangkurat University1
Abdul GafurLambung Mangkurat University1
Najwah NajwahLambung Mangkurat University1
Dody NovrialJenderal Soedirman University1
Alfi MuntafiahJenderal Soedirman University1
Johanes Hasian SiahaanJenderal Soedirman University1
Sofyan HardiJenderal Soedirman University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jos.unsoed.ac.id/index.php/jm/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US"> Detoxification of Cadmium on Albino Rats (Rattus norvegicus) with Natural Chelator of Fruiting Body Extract of Ganoderma lucidum</dc:title>
	<dc:creator>Taufiq, Hameda Dhaka Kusuma</dc:creator>
	<dc:creator>Hernayanti, Hernayanti</dc:creator>
	<dc:creator>Ratnaningtyas, Nuniek Ina</dc:creator>
	<dc:description xml:lang="en-US">Cadmium is a heavy metal pollutant sourced from various industries and toxic to the kidneys. Cadmium exposure can be used natural chelator of ethanol extract of the fruiting body of Ganoderma lucidum. The aim of the study was to determine the effect and effective dose of the ethanolic extract of the fruiting body of G. lucidum on reducing the toxicity effect of cadmium in male albino rats (Rattus norvegicus) Wistar strain. The research design was experimental research, which consisted of 5 treatment levels. The research parameters were blood cadmium, β2-microglobulin, malondialdehyde, and superoxide dismutase levels. The ethanolic extract of fruiting body of G. lucidum was tested by gas chromatography-mass spectrometry (GCMS) to determine linalool as active compounds. The results of each parameter had a significant effect, which decreased blood cadmium, β2M and MDA levels, and increased SOD level that linear according to the addition of the dose of ethanol extract of the fruiting body of G. lucidum. Blood cadmium levels with β2M and MDA levels had a positive correlation, while blood cadmium levels with SOD levels had a negative correlation. The dominant compound detected was linalool which has potential as a radical scavenger. The dose of 750 mg.kgBW-1 is the effective dose of the ethanolic extract of fruiting body of G. lucidum based on a decrease in blood cadmium levels (54.10%), β2M (63.94%) and MDA (20.31%), as well as an increase in SOD levels (14.20%) compared to sick control.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Jenderal Soedirman</dc:publisher>
	<dc:date>2023-03-20</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jos.unsoed.ac.id/index.php/jm/article/view/5844</dc:identifier>
	<dc:identifier>10.20884/1.jm.2023.18.1.5844</dc:identifier>
	<dc:source xml:lang="en-US">Molekul; Vol 18 No 1 (2023); 21-28</dc:source>
	<dc:source>2503-0310</dc:source>
	<dc:source>1907-9761</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jos.unsoed.ac.id/index.php/jm/article/view/5844/3852</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Molekul</dc:rights>
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