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Chiral Separation of Econazole by High Performance Liquid Chromatography Method using Cyclodextrin as Chiral Column

Molekul: Jurnal Ilmiah Kimia · Vol. 17 No. 2 (2022) · hlm. 252–260

DOI
10.20884/1.jm.2022.17.2.6348
ISSN
2503-0310, 1907-9761
Terbit
2022-07-21
Penerbit
Universitas Jenderal Soedirman
Bahasa
eng

Abstrak

The chiral separation of econazole, an antifungal drug with one chiral center has been successfully carried out using the high-performance liquid chromatography (HPLC) method. Enantioresolution of econazole (Rs = 2.29) was achieved using cyclodextrin-based chiral column (Astec Cyclobond, 25 cm × 4.6 mm × 5 μm), mobile phase composition of acetonitrile: water (0.2% HCOOH) (20:80, v/v), and UV detection of 220 nm.The optimized HPLC method has been applied for the quantitative determination of econazole in the pharmaceutical (liquid) sample withpercentage recovery of 100.75 % (RSD = 0,95%; n = 3). The effect of several HPLC parameters on the chiral separation of econazole was also evaluated and the method was successfully validated in terms of linearity, accuracy, precision, and selectivity. The present HPLC method was simple, short analysis time, and high resolution.

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  • Jenderal Soedirman University
  • Universitas Gadjah Mada
  • IPB University
  • Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
  • Sebelas Maret University
  • Universitas Airlangga
  • Tohoku University
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Rekan penulisOrganisasiArtikel bersama
Dian Riana NingsihJenderal Soedirman University7
Zusfahair ZusfahairJenderal Soedirman University7
Bilalodin BilalodinJenderal Soedirman University4
Shu YinTohoku University4
Roy AndreasJenderal Soedirman University4
Khusnul AfifahJenderal Soedirman University3
Anung RiapanitraJenderal Soedirman University2
Febiyanto FebiyantoJenderal Soedirman University2
Niken Istikhari MuslihahJenderal Soedirman University2
Ari AsnaniJenderal Soedirman University2
Isnaeni IsnaeniNational Research and Innovation Agency2
Vania Amelia AzmiJenderal Soedirman University2
Rini LarasatiInstitute of Multidisciplinary Research for Advanced Materials, Tohoku University2
Fatma Ulfatun NajichaSebelas Maret University1
Agus Muhamad SolehIPB University1
Muhammad Sofi Khoerul AmalJenderal Soedirman University1
Mohammad AfifJenderal Soedirman University1
Sukma SewijiJenderal Soedirman University1
Abdullah AbdullohAfiliasi tidak diketahui1
Didik Prasetyoko Didik PrasetyokoAfiliasi tidak diketahui1
Siti MaryamUniversitas Airlangga1
Triyono TriyonoUniversitas Gadjah Mada1
Wega TrisunaryantiUniversitas Gadjah Mada1
Nanik Siti AminahUniversitas Airlangga1
KUSWANDI KUSWANDIAfiliasi tidak diketahui1
I Made ArtikaIPB University1
AHMAD ENDANG ZAINAL HASANIPB University1
Bin LiuInstitute of Multidisciplinary Research for Advanced Materials, Tohoku University1
Tsugio SatoInstitute of Multidisciplinary Research for Advanced Materials, Tohoku University1
Dwi SiswantaUniversitas Gadjah Mada1
Dhony HermantoUniversity of Mataram1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jos.unsoed.ac.id/index.php/jm/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US"> Chiral Separation of Econazole by High Performance Liquid Chromatography Method using Cyclodextrin as Chiral Column</dc:title>
	<dc:creator>Hermawan, Dadan</dc:creator>
	<dc:creator>Cacu, Cacu</dc:creator>
	<dc:creator>Salsabila, Khansa</dc:creator>
	<dc:creator>Suwandri, Suwandri</dc:creator>
	<dc:creator>Fatoni, Amin</dc:creator>
	<dc:creator>Sulaeman, Uyi</dc:creator>
	<dc:creator>Iswanto, Ponco</dc:creator>
	<dc:creator>Mudasir, Mudasir</dc:creator>
	<dc:creator>Aboul-Enein, Hassan Y.</dc:creator>
	<dc:description xml:lang="en-US">The chiral separation of econazole, an antifungal drug with one chiral center has been successfully carried out using the high-performance liquid chromatography (HPLC) method. Enantioresolution of econazole (Rs = 2.29) was achieved using cyclodextrin-based chiral column (Astec Cyclobond, 25 cm × 4.6 mm × 5 μm), mobile phase composition of acetonitrile : water (0.2% HCOOH) (20:80, v/v), and UV detection of 220 nm.The optimized HPLC method has been applied for the quantitative determination of econazole in the pharmaceutical (liquid) sample withpercentage recovery of 100.75 % (RSD = &amp;nbsp;&amp;nbsp;0,95%; n = 3). The effect of several HPLC parameters on the chiral separation of econazole was also evaluated and the method was successfully validated in terms of linearity, accuracy, precision, and selectivity. The present HPLC method was simple, short analysis time, and high resolution.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Jenderal Soedirman</dc:publisher>
	<dc:date>2022-07-21</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
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	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jos.unsoed.ac.id/index.php/jm/article/view/6348</dc:identifier>
	<dc:identifier>10.20884/1.jm.2022.17.2.6348</dc:identifier>
	<dc:source xml:lang="en-US">Molekul; Vol 17 No 2 (2022); 252-260</dc:source>
	<dc:source>2503-0310</dc:source>
	<dc:source>1907-9761</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jos.unsoed.ac.id/index.php/jm/article/view/6348/3191</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Molekul</dc:rights>
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