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Application of Box-Behnken Design for the Extraction of Padina australis

Molekul: Jurnal Ilmiah Kimia · Vol. 17 No. 2 (2022) · hlm. 270–280

DOI
10.20884/1.jm.2022.17.2.6359
ISSN
2503-0310, 1907-9761
Terbit
2022-07-21
Penerbit
Universitas Jenderal Soedirman
Bahasa
eng

Abstrak

Optimization extraction of the brown algae Padina australis using the Box-Behnken design has been carried out. Box-Behnken design in relation to Response Surface Methodology analysis was conducted with four experimental factors (i.e., solvent concentration, temperature, extraction time, and sample to solvents ratio) towards the responses of yield antioxidant, anti-tyrosinase, anti-glycation, total phenolic content, and fucoxanthin content, completing with 29 running experiments. P. australis extraction's optimum condition was acquired at 79.99% solvent concentration, 18.48 hours extraction time, 44.50ºC temperature, and 1:9 ratio powders and solvents. The optimum condition provided a 7.30% extraction yield, 43.94% antioxidant activity, 86.83% anti-tyrosinase, 98.06% anti-glycation, 9.53 mg GAE/g total phenolic content, and 347.55 µg/g fucoxanthin content. Respond Surface Methodology analysis with the Box-Behnken design succeeded in making the appropriate model for producing the optimum P. australis extract.

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  • National Research and Innovation Agency
  • Bandung Institute of Technology
  • University of Hawaiʻi at Mānoa
  • Sultan Ageng Tirtayasa University
  • State University of Semarang
  • Nara Institute of Science and Technology
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Rekan penulisOrganisasiArtikel bersama
Setyanto Tri WahyudiIPB University3
I Made SumertajayaIPB University2
Nampiah SukarnoIPB University2
Latifah Kosim DarusmanIPB University2
Mashuri WaiteUniversity of Hawaiʻi at Mānoa2
Muhammad Eka PrastyaNational Research and Innovation Agency2
Shadila Fira AsokaIPB University2
Bambang RiyantoIPB University2
Fikry AwaluddinIPB University2
Eka Winarni SapitriIPB University2
Auliya IlmiawatiIPB University2
Asep SaefuddinIPB University1
Viarti EminitaAfiliasi tidak diketahui1
Kusman SadikIPB University1
Aji Hamim WigenaIPB University1
Faula ArinaSultan Ageng Tirtayasa University1
Nindya WulandariIPB University1
Erfiani ErfianiIPB University1
Irzaman IrzamanIPB University1
Budi SusetyoIPB University1
Ratna Nur Mustika SanusiState University of Semarang1
I Nyoman Pugeg AryanthaBandung Institute of Technology1
Utut WidyastutiIPB University1
Rohani Cinta Badia GintingIPB University1
Sihegiko KanayaNara Institute of Science and Technology1
Sintho Wahyuning ArdieIPB University1
Soekisman TjitrosoedirdjoSoutheast Asian Regional Centre for Tropical Biology1
Za’aziza Ridha JuliaIPB University1
Muhamad İnsanuBandung Institute of Technology1
Abdul RohmanUniversitas Gadjah Mada1
Mohamad RafiIPB University1
Alfi Hudatul KaromahIPB University1
Dewi Anggraini SeptaningsihIPB University1
Nanik Siti AminahUniversitas Airlangga1
Rika Indri AstutiIPB University1
Nadila Fany AshafaniIPB University1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jos.unsoed.ac.id/index.php/jm/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US"> Application of Box-Behnken Design for the Extraction of Padina australis</dc:title>
	<dc:creator>Nursid, Muhammad</dc:creator>
	<dc:creator>Permatasari, Anissa</dc:creator>
	<dc:creator>Syafitri, Utami Dyah</dc:creator>
	<dc:creator>Batubara, Irmanida</dc:creator>
	<dc:description xml:lang="en-US">Optimization extraction of the brown algae Padina australis using the Box-Behnken design has been carried out. Box-Behnken design in relation to Response Surface Methodology analysis was conducted with four experimental factors (i.e., solvent concentration, temperature, extraction time, and sample to solvents ratio) towards the responses of yield antioxidant, anti-tyrosinase, anti-glycation, total phenolic content, and fucoxanthin content, completing with 29 running experiments. P. australis extraction's optimum condition was acquired at 79.99% solvent concentration, 18.48 hours extraction time, 44.50ºC temperature, and 1:9 ratio powders and solvents. The optimum condition provided a 7.30% extraction yield, 43.94% antioxidant activity, 86.83% anti-tyrosinase, 98.06% anti-glycation, 9.53 mg GAE/g total phenolic content, and 347.55 µg/g fucoxanthin content. Respond Surface Methodology analysis with the Box-Behnken design succeeded in making the appropriate model for producing the optimum P. australis extract.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Jenderal Soedirman</dc:publisher>
	<dc:date>2022-07-21</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jos.unsoed.ac.id/index.php/jm/article/view/6359</dc:identifier>
	<dc:identifier>10.20884/1.jm.2022.17.2.6359</dc:identifier>
	<dc:source xml:lang="en-US">Molekul; Vol 17 No 2 (2022); 270-280</dc:source>
	<dc:source>2503-0310</dc:source>
	<dc:source>1907-9761</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jos.unsoed.ac.id/index.php/jm/article/view/6359/3193</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Molekul</dc:rights>
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