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Sesquiterpenoids from Stem Bark of Chisocheton lasiocarpus and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell

Molekul: Jurnal Ilmiah Kimia · Vol. 17 No. 3 (2022) · hlm. 413–420

DOI
10.20884/1.jm.2022.17.3.6425
ISSN
2503-0310, 1907-9761
Terbit
2022-11-19
Penerbit
Universitas Jenderal Soedirman
Bahasa
eng

Abstrak

Sesquiterpenoids are derivatives of terpenoid compound that have a diverse skeleton and broad spectrum of biological activities, particularly anticancer activity. This research reported the isolation and elucidation structure of sesquiterpenoid from Chisocheton lasiocarpus stem bark, as well as their cytotoxic activity. Four sesquiterpenoid compounds, namely eudesm-4(15)-ene-1β,6β-diol (1), allo-aromadendrane-10α,14-diol (2), allo-aromadendrane-10β,14-diol (3) and guaianediol (4), were isolated for the first time from Chisocheton lasiocarpus stem bark. The chemical structure of all compounds was identified by spectroscopic analysis, including IR, MS, 1H-NMR, 13C-NMR and DEPT, and compared with previous reported spectral data. The cytotoxic activity of the isolated compounds against MCF-7 breast cancer line were examined by using the resazurin method. The results showed compound 1 shown the highest cytotoxic activity with IC50 108.08 ± 0.58 µM.

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  • Padjadjaran University
  • National Research and Innovation Agency
  • Universiti Sains Malaysia
  • Indonesian Institute of Sciences
  • Universitas Muhammadiyah Semarang
  • Yamagata University
  • Mulawarman University
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Rekan penulisOrganisasiArtikel bersama
Ace Tatang HidayatPadjadjaran University44
Mohamad Nurul AzmiUniversiti Sains Malaysia35
Dewa Gede KatjaSam Ratulangi University20
Hadi KuncoroMulawarman University14
Desi Harneti Putri HuspaPadjadjaran University14
Harizon HarizonUniversitas Jambi13
Muhammad HanafiNational Research and Innovation Agency13
Wahyu SafriansyahPadjadjaran University12
Fajar Fauzi AbdullahPadjadjaran University12
Tati HerlinaPadjadjaran University10
Khalijah AwangUniversity of Malaya10
Agus SafariPadjadjaran University10
Mohamad Azlan NafiahSultan Idris Education University10
Ricson P. HutagaolUniversitas Nusa Bangsa9
Euis JulaehaPadjadjaran University8
Sandra Amalia RiyadiPadjadjaran University8
Dudi RunadiPadjadjaran University8
Purnama PurnamaPadjadjaran University8
Aprilia Permata SariPadjadjaran University7
Tjandrawati MozefIndonesian Institute of Sciences6
Gian PrimahanaNational Research and Innovation Agency6
Akhmad DarmawanIndonesian Institute of Sciences6
Ronny LesmanaPadjadjaran University5
Raihan Fathurrahman HasbillaPadjadjaran University3
Susianti SusiantiPadjadjaran University3
Sari PurbayaUniversitas Jenderal Achmad Yani3

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Sumber metadata: OAI-PMH (metadata jurnal) https://jos.unsoed.ac.id/index.php/jm/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US"> Sesquiterpenoids from Stem Bark of Chisocheton lasiocarpus and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell</dc:title>
	<dc:creator>Supratman, Unang</dc:creator>
	<dc:creator>Parulian, Samuel San</dc:creator>
	<dc:creator>Nurlelasari, Nurlelasari</dc:creator>
	<dc:creator>Naini, Al Arofatus</dc:creator>
	<dc:creator>Mayanti, Tri</dc:creator>
	<dc:creator>Hilmayanti, Erina</dc:creator>
	<dc:creator>Harneti, Desi</dc:creator>
	<dc:creator>Darwati, Darwati</dc:creator>
	<dc:creator>Maharani, Rani</dc:creator>
	<dc:creator>Farabi, Kindi</dc:creator>
	<dc:creator>Anwar, Risyandi</dc:creator>
	<dc:creator>Fajriah, Sofa</dc:creator>
	<dc:creator>Azmi, Muhamad Nurul</dc:creator>
	<dc:creator>Shiono, Yoshihito</dc:creator>
	<dc:description xml:lang="en-US">Sesquiterpenoids are derivatives of terpenoid compound that have a diverse skeleton and broad spectrum of biological activities, particularly anticancer activity. This research reported the isolation and elucidation structure of sesquiterpenoid from Chisocheton lasiocarpus stem bark, as well as their cytotoxic activity. Four sesquiterpenoid compounds, namely eudesm-4(15)-ene-1β,6β-diol (1), allo-aromadendrane-10α,14-diol (2), allo-aromadendrane-10β,14-diol (3) and guaianediol (4), were isolated for the first time from Chisocheton lasiocarpus stem bark. The chemical structure of all compounds was identified by spectroscopic analysis, including IR, MS, 1H-NMR, 13C-NMR and DEPT, and compared with previous reported spectral data. The cytotoxic activity of the isolated compounds against MCF-7 breast cancer line were examined by using the resazurin method. The results showed compound 1 shown the highest cytotoxic activity with IC50 108.08 ± 0.58 µM.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Jenderal Soedirman</dc:publisher>
	<dc:date>2022-11-19</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jos.unsoed.ac.id/index.php/jm/article/view/6425</dc:identifier>
	<dc:identifier>10.20884/1.jm.2022.17.3.6425</dc:identifier>
	<dc:source xml:lang="en-US">Molekul; Vol 17 No 3 (2022); 413-420</dc:source>
	<dc:source>2503-0310</dc:source>
	<dc:source>1907-9761</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jos.unsoed.ac.id/index.php/jm/article/view/6425/3456</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2022 Molekul</dc:rights>
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