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Morelloflavone and Molecular Docking from Stembark of Chisocheton lasiocarpus and Its Cytotoxic Activity Against Breast Cancer Mcf-7 Cell Lines

Molekul: Jurnal Ilmiah Kimia · Vol. 18 No. 2 (2023) · hlm. 200–209

DOI
10.20884/1.jm.2023.18.2.6845
ISSN
2503-0310, 1907-9761
Terbit
2023-07-10
Penerbit
Universitas Jenderal Soedirman
Bahasa
eng

Abstrak

Chisocheton is a plant of the Meliaceae family which has been known as a source of limonoids, triterpenoids, steroids, alkaloids and phenolics. This plant is the second largest in the Meliaceae, with 53 species widely distributed in tropical and subtropical regions including Indonesia. From this genus, compounds that have interesting activities have been found, including anti-inflammatory, antimalarial, cytotoxic, antitumor and anticancer. One of the species that has the potential to find new compounds is Chisocheton lasiocarpus because there are still few phytochemical studies. This study aims to inform the structural elucidation of one of the compounds from the stem bark of C. lasiocarpus, namely morelloflavone and its cytotoxic potential against breast cancer cells using the in silico method against ER-α receptors (PDB code: 3ERD), ER-β (PDB code: 1QKM). ) and HER-2 (GDP code: 3PP0).

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  • Padjadjaran University
  • National Research and Innovation Agency
  • Indonesian Institute of Sciences
  • Yamagata University
  • Universiti Sains Malaysia
  • Mulawarman University
  • Sam Ratulangi University
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Rekan penulisOrganisasiArtikel bersama
Al Arofatus NainiPadjadjaran University42
Sofa FajriahNational Research and Innovation Agency39
Yoshihito ShionoYamagata University36
Ace Tatang HidayatPadjadjaran University31
Mohamad Nurul AzmiUniversiti Sains Malaysia24
Erina HilmayantiPadjadjaran University16
Desi Harneti Putri HuspaPadjadjaran University14
Hadi KuncoroMulawarman University12
Dewa Gede KatjaSam Ratulangi University12
Fajar Fauzi AbdullahPadjadjaran University12
Wahyu SafriansyahPadjadjaran University11
Risyandi AnwarUniversitas Muhammadiyah Semarang11
Agus SafariPadjadjaran University10
Tati HerlinaPadjadjaran University9
Harizon HarizonUniversitas Jambi9
Mohamad Azlan NafiahSultan Idris Education University9
Ferry Ferdiansyah SofianPadjadjaran University9
Euis JulaehaPadjadjaran University7
Khalijah AwangUniversity of Malaya7
Sandra Amalia RiyadiPadjadjaran University5
Aprilia Permata SariPadjadjaran University5
Ronny LesmanaPadjadjaran University4
Ricson P. HutagaolUniversitas Nusa Bangsa4
Rurini RetnowatiUniversity of Brawijaya4
Raihan Fathurrahman HasbillaPadjadjaran University3
Susianti SusiantiPadjadjaran University3
Sari PurbayaUniversitas Jenderal Achmad Yani3
Gian PrimahanaNational Research and Innovation Agency3
Nina ArtantiIndonesian Institute of Sciences2
Linar Zalinar UdinIndonesian Institute of Sciences2
Arif Rahman HakimPadjadjaran University2
Dikdik KurniaPadjadjaran University2

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Sumber metadata: OAI-PMH (metadata jurnal) https://jos.unsoed.ac.id/index.php/jm/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US"> Morelloflavone and Molecular Docking from Stembark of Chisocheton lasiocarpus and Its Cytotoxic Activity Against Breast Cancer Mcf-7 Cell Lines</dc:title>
	<dc:creator>Nurlelasari, Nurlelasari</dc:creator>
	<dc:creator>Harneti, Desi</dc:creator>
	<dc:creator>Maharani, Rani</dc:creator>
	<dc:creator>Darwati, Darwati</dc:creator>
	<dc:creator>Mayanti, Tri</dc:creator>
	<dc:creator>Farabi, Kindi</dc:creator>
	<dc:creator>Hanafi, Muhammad</dc:creator>
	<dc:creator>Supratman, Unang</dc:creator>
	<dc:description xml:lang="en-US">Chisocheton is a plant of the Meliaceae family which has been known as a source of limonoids, triterpenoids, steroids, alkaloids and phenolics. This plant is the second largest in the Meliaceae, with 53 species widely distributed in tropical and subtropical regions including Indonesia. From this genus, compounds that have interesting activities have been found, including anti-inflammatory, antimalarial, cytotoxic, antitumor and anticancer. One of the species that has the potential to find new compounds is Chisocheton lasiocarpus because there are still few phytochemical studies. This study aims to inform the structural elucidation of one of the compounds from the stem bark of C. lasiocarpus, namely morelloflavone and its cytotoxic potential against breast cancer cells using the in silico method against ER-α receptors (PDB code: 3ERD), ER-β (PDB code: 1QKM). ) and HER-2 (GDP code: 3PP0).</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Jenderal Soedirman</dc:publisher>
	<dc:date>2023-07-10</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
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	<dc:identifier>https://jos.unsoed.ac.id/index.php/jm/article/view/6845</dc:identifier>
	<dc:identifier>10.20884/1.jm.2023.18.2.6845</dc:identifier>
	<dc:source xml:lang="en-US">Molekul; Vol 18 No 2 (2023); 200-209</dc:source>
	<dc:source>2503-0310</dc:source>
	<dc:source>1907-9761</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jos.unsoed.ac.id/index.php/jm/article/view/6845/4174</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2023 Molekul</dc:rights>
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