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The Sesquiterpenoids from the Stem Bark of Dysoxylum excelsum and Their Cytotoxic Activities against HeLa Cancer Cell Lines

Molekul: Jurnal Ilmiah Kimia · Vol. 19 No. 1 (2024) · hlm. 109–116

DOI
10.20884/1.jm.2024.19.1.9406
ISSN
2503-0310, 1907-9761
Terbit
2024-03-14
Penerbit
Universitas Jenderal Soedirman
Bahasa
eng

Abstrak

Sesquiterpenoids belong to a group of terpenoid compounds with interesting structures that are abundant in natural products especially in higher plants. Sesquiterpenoids have a wide variety of bioactivities with great potential cytotoxic activity. The species Dysoxylum excelsum belongs to the Meliaceae family known as higher plant, but only a few sesquiterpenoids have been reported particularly for their cytotoxic activity. Therefore, this research aims to isolate and elucidate the sesquiterpenoids structure from D. excelsum stem bark and examines their cytotoxicity against HeLa cervical cancer cells. Through various column chromatography separations, four known sesquiterpenes namely β-caryophyllene oxide (1), caryophyllenol II (2), humulene dioxide A (3), and guai-6-en-10β-ol (4) were acquired from the n-hexane extract. Compounds 1-4 were isolated for the first time from D. excelsum species. The sesquiterpenoid structures were elucidated according to Nuclear Magnetic Resonance, Infrared, and HR-TOF-MS analysis. The cytotoxicity compounds 1-4 was determined against HeLa cervical cancer cells by examination with the PrestoBlue method and compound 3 exhibited the most potent cytotoxicity with an IC50 value of 160.74 µM. Keywords: cytotoxic activity, Dysoxylum excelsum, HeLa, Meliaceae, sesquiterpenoid.

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  • Universitas Jambi
  • National Research and Innovation Agency
  • Indonesian Institute of Sciences
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  • Universiti Sains Malaysia
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Rekan penulisOrganisasiArtikel bersama
Kindi FarabiPadjadjaran University40
Nurlelasari NurlelasariPadjadjaran University37
Desi HarnetiPadjadjaran University34
Rani MaharaniPadjadjaran University27
Yoshihito ShionoYamagata University22
Ace Tatang HidayatPadjadjaran University18
Mohamad Nurul AzmiUniversiti Sains Malaysia17
Darwati DarwatiPadjadjaran University15
Dewa Gede KatjaSam Ratulangi University10
Erina HilmayantiPadjadjaran University10
Tati HerlinaPadjadjaran University8
Febbry RomundzaUniversitas Jambi7
Risyandi AnwarUniversitas Muhammadiyah Semarang7
Wahyu SafriansyahPadjadjaran University6
Hadi KuncoroMulawarman University6
Fajar Fauzi AbdullahPadjadjaran University5
Ricson P. HutagaolUniversitas Nusa Bangsa5
Desi Harneti Putri HuspaPadjadjaran University5
Ronny LesmanaPadjadjaran University5
Euis JulaehaPadjadjaran University4
Khalijah AwangUniversity of Malaya4
Tjandrawati MozefIndonesian Institute of Sciences4
Gian PrimahanaNational Research and Innovation Agency4
Agus SafariPadjadjaran University4
Muhammad HanafiNational Research and Innovation Agency4
Aprilia Permata SariPadjadjaran University4
Mohamad Azlan NafiahSultan Idris Education University4
Raihan Fathurrahman HasbillaPadjadjaran University3
Susianti SusiantiPadjadjaran University3
Akhmad DarmawanIndonesian Institute of Sciences3
Aulia SanovaUniversitas Jambi2
Haryanto HaryantoUniversitas Jambi2
Sari PurbayaUniversitas Jenderal Achmad Yani2

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Sumber metadata: OAI-PMH (metadata jurnal) https://jos.unsoed.ac.id/index.php/jm/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">The Sesquiterpenoids from the Stem Bark of Dysoxylum excelsum and Their Cytotoxic Activities against HeLa Cancer Cell Lines</dc:title>
	<dc:creator>Supratman, Unang</dc:creator>
	<dc:creator>Kautsari, Arsi</dc:creator>
	<dc:creator>Naini, Al Arofatus</dc:creator>
	<dc:creator>Riyadi, Sandra Amalia</dc:creator>
	<dc:creator>Mayanti, Tri</dc:creator>
	<dc:creator>Harizon, Harizon</dc:creator>
	<dc:creator>Fajriah, Sofa</dc:creator>
	<dc:description xml:lang="en-US">Sesquiterpenoids belong to a group of terpenoid compounds with interesting structures that are abundant in natural products especially in higher plants. Sesquiterpenoids have a wide variety of bioactivities with great potential cytotoxic activity. The species Dysoxylum excelsum belongs to the Meliaceae family known as higher plant, but only a few sesquiterpenoids have been reported particularly for their cytotoxic activity. Therefore, this research aims to isolate and elucidate the sesquiterpenoids structure from D. excelsum stem bark and examines their cytotoxicity against HeLa cervical cancer cells. Through various column chromatography separations, four known sesquiterpenes namely β-caryophyllene oxide (1), caryophyllenol II (2), humulene dioxide A (3), and guai-6-en-10β-ol (4) were acquired from the n-hexane extract. Compounds 1-4 were isolated for the first time from D. excelsum species. The sesquiterpenoid structures were elucidated according to Nuclear Magnetic Resonance, Infrared, and HR-TOF-MS analysis. The cytotoxicity compounds 1-4 was determined against HeLa cervical cancer cells by examination with the PrestoBlue method and compound 3 exhibited the most potent cytotoxicity with an IC50 value of 160.74 µM.
&amp;nbsp;
Keywords: cytotoxic activity, Dysoxylum excelsum, HeLa, Meliaceae, sesquiterpenoid.</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Jenderal Soedirman</dc:publisher>
	<dc:date>2024-03-14</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jos.unsoed.ac.id/index.php/jm/article/view/9406</dc:identifier>
	<dc:identifier>10.20884/1.jm.2024.19.1.9406</dc:identifier>
	<dc:source xml:lang="en-US">Molekul; Vol 19 No 1 (2024); 109-116</dc:source>
	<dc:source>2503-0310</dc:source>
	<dc:source>1907-9761</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jos.unsoed.ac.id/index.php/jm/article/view/9406/5167</dc:relation>
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