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The comparison of the Sensitivity Value of Gold Nanoparticles (AuNPs) between ANTAM and Commercial Gold Sources in the Detection of SARS-CoV-2: A Preliminary Study

Molekul: Jurnal Ilmiah Kimia · Vol. 19 No. 3 (2024) · hlm. 514–522

DOI
10.20884/1.jm.2024.19.3.11037
ISSN
2503-0310, 1907-9761
Terbit
2024-11-24
Penerbit
Universitas Jenderal Soedirman
Bahasa
eng

Abstrak

Gold nanoparticles (AuNPs) have been developed as a colorimetric sensor to detect SARS-CoV-2 with surface modification using N-ethyl-N′-(3-(dimethylamino)propyl) carbodiimide/N-hydroxysuccinimide (EDC/NHS) and angiotensin-converting enzyme II (ACE-2). The gold sources used in the synthesis are produced by PT Aneka Tambang Indonesia (ANTAM) and commercial gold nanoparticles (AuNPs). This study compares the sensitivity values of ANTAM gold sources and commercial AuNPs in detecting SARS-CoV-2. The AuNPs-ANTAM detection test against the SARS-CoV-2 resulted in LoD and LoQ values of 5.38 ng/mL and 17.92 ng/mL, in the linearity curve range of 10 – 50 ng/mL, respectively. LoD and LoQ values of commercial AuNPs for detecting SARS-CoV-2, respectively, are 6.69 ng/mL and 22.31 ng/mL in the linearity curve range of 10 – 50 ng/mL. Based on the LoD and LoQ values, AuNPs-ANTAM is more sensitive than commercial AuNPs in detecting SARS-CoV-2 over the same range of linearity curves. Keywords: ACE-2, colorimetry sensor, EDC/NHS, gold nanoparticles, SARS-CoV-2, surface Modifications

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  • National Research and Innovation Agency
  • State University of Jakarta
  • Padjadjaran University
  • IPB University
  • Syarif Hidayatullah State Islamic University Jakarta
  • Jenderal Soedirman University
  • State University of Semarang
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Rekan penulisOrganisasiArtikel bersama
Joko WidodoState University of Semarang1
Eko PrasetyaAfiliasi tidak diketahui1
Maulida Ayu FitrianiMuhammadiyah University Purwokerto1
Maria ParistiowatiState University of Jakarta1
Dian IlmiyatiState University of Jakarta1
Elsyafahriza RiskyPadjadjaran University1
Uwes Anis ChaerumanState University of Jakarta1
Muhammad Al MuttaqiiNational Research and Innovation Agency1
Indri YatiNational Research and Innovation Agency1
Amalia Kurnia AminNational Research and Innovation Agency1
Muhammad RidwanUniversity of Indonesia1
Irwan KurniaPadjadjaran University1
Feri MukhayaniNational Research and Innovation Agency1
Denisa Fitri SalsabilaPadjadjaran University1
Fildzah ‘AdanyNational Research and Innovation Agency1
Zetryana Puteri TachrimNational Research and Innovation Agency1
ALI H. JAWADUniversiti Teknologi MARA1

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Sumber metadata: OAI-PMH (metadata jurnal) https://jos.unsoed.ac.id/index.php/jm/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US"> The comparison of the Sensitivity Value of Gold Nanoparticles (AuNPs) between ANTAM and Commercial Gold Sources in the Detection of SARS-CoV-2: A Preliminary Study</dc:title>
	<dc:creator>Istianah, Istianah</dc:creator>
	<dc:creator>Vidiawati, Agustina</dc:creator>
	<dc:creator>Alfiyan, Akhmad Irfan</dc:creator>
	<dc:creator>Andreani, Agustina Sus</dc:creator>
	<dc:description xml:lang="en-US">Gold nanoparticles (AuNPs) have been developed as a colorimetric sensor to detect SARS-CoV-2 with surface modification using N-ethyl-N′-(3-(dimethylamino)propyl) carbodiimide/N-hydroxysuccinimide (EDC/NHS) and angiotensin-converting enzyme II (ACE-2). The gold sources used in the synthesis are produced by PT Aneka Tambang Indonesia (ANTAM) and commercial gold nanoparticles (AuNPs). This study compares the sensitivity values of ANTAM gold sources and commercial AuNPs in detecting SARS-CoV-2. The AuNPs-ANTAM detection test against the SARS-CoV-2 resulted in LoD and LoQ values of 5.38 ng/mL and 17.92 ng/mL, in the linearity curve range of 10 – 50 ng/mL, respectively. LoD and LoQ values of commercial AuNPs for detecting SARS-CoV-2, respectively, are 6.69 ng/mL and 22.31 ng/mL in the linearity curve range of 10 – 50 ng/mL. Based on the LoD and LoQ values, AuNPs-ANTAM is more sensitive than commercial AuNPs in detecting SARS-CoV-2 over the same range of linearity curves.&amp;nbsp;
Keywords: ACE-2, colorimetry sensor, EDC/NHS, gold nanoparticles, SARS-CoV-2, surface Modifications</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Jenderal Soedirman</dc:publisher>
	<dc:date>2024-11-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jos.unsoed.ac.id/index.php/jm/article/view/11037</dc:identifier>
	<dc:identifier>10.20884/1.jm.2024.19.3.11037</dc:identifier>
	<dc:source xml:lang="en-US">Molekul; Vol 19 No 3 (2024); 514-522</dc:source>
	<dc:source>2503-0310</dc:source>
	<dc:source>1907-9761</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jos.unsoed.ac.id/index.php/jm/article/view/11037/5858</dc:relation>
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