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The Cytotoxic Evaluation of Steroids Isolated from Dysoxylum alliaceum (Blume) Blume ex A.Juss.

Molekul: Jurnal Ilmiah Kimia · Vol. 19 No. 3 (2024) · hlm. 471–480

DOI
10.20884/1.jm.2024.19.3.11439
ISSN
2503-0310, 1907-9761
Terbit
2024-11-24
Penerbit
Universitas Jenderal Soedirman
Bahasa
eng

Abstrak

Dysoxylum alliaceum belongs to the Dysoxylum genus (Meliaceae) and there are few reports concerning the phytochemical components of this plant. To examine the chemical constituents of Dysoxylum alliaceum stem bark, a phytochemical study has been conducted and identified five known steroids, 3β,16β-dihydroxy-24(S)-methyl cholestenol (1), ergosta-5,22-dien-3β-ol (2), ergosta-7,24(28)-dien-3β-ol (3), 22(E)-ergosta-6,22-dien-3β,5α,8α-triol (4), and 20α-dihydroprogesterone (5) from its ethanolic extract. Spectroscopic data such as FT-IR, HR-ESI-MS, 1D, and 2D NMR as well as comparison with previously published spectral data were used to identify the chemical structures of compounds 1–5. Furthermore, these steroids 1-5 were assessed in vitro regarding their cytotoxic effect against A549 lung cancer cell lines and revealed weak to inactive with IC50 values ranging from 68.52 to >150 µM. Keywords: A549 cell lines, cytotoxic evaluation, Dysoxylum alliaceum (blume) blume ex a.juss, meliaceae, steroid

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Rekan penulisOrganisasiArtikel bersama
Kindi FarabiPadjadjaran University36
Nurlelasari NurlelasariPadjadjaran University35
Desi HarnetiPadjadjaran University32
Sofa FajriahNational Research and Innovation Agency29
Rani MaharaniPadjadjaran University27
Yoshihito ShionoYamagata University20
Ace Tatang HidayatPadjadjaran University17
Darwati DarwatiPadjadjaran University14
Erina HilmayantiPadjadjaran University9
Harizon HarizonUniversitas Jambi9
Tati HerlinaPadjadjaran University8
Dewa Gede KatjaSam Ratulangi University8
Wahyu SafriansyahPadjadjaran University6
Risyandi AnwarUniversitas Muhammadiyah Semarang6
Ferry Ferdiansyah SofianPadjadjaran University6
Hadi KuncoroMulawarman University5
Fajar Fauzi AbdullahPadjadjaran University5
Desi Harneti Putri HuspaPadjadjaran University5
Rurini RetnowatiUniversity of Brawijaya5
Euis JulaehaPadjadjaran University4
Raihan Fathurrahman HasbillaPadjadjaran University4
Susianti SusiantiPadjadjaran University4
Agus SafariPadjadjaran University4
Muhammad HanafiNational Research and Innovation Agency4
Mohamad Azlan NafiahSultan Idris Education University4
Khalijah AwangUniversity of Malaya3
Aprilia Permata SariPadjadjaran University3
Ricson P. HutagaolUniversitas Nusa Bangsa2
Sari PurbayaUniversitas Jenderal Achmad Yani2
Arif Rahman HakimPadjadjaran University2
Dikdik KurniaPadjadjaran University2
Dadan SumiarsaPadjadjaran University2
Achmad ZainuddinPadjadjaran University2
Supriatno SupriatnoUniversitas Gadjah Mada2

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Sumber metadata: OAI-PMH (metadata jurnal) https://jos.unsoed.ac.id/index.php/jm/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.
Metadata asli (oai_dc) 
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	<dc:title xml:lang="en-US">The Cytotoxic Evaluation of Steroids Isolated from Dysoxylum alliaceum (Blume) Blume ex A.Juss.</dc:title>
	<dc:creator>Riyadi, Sandra Amalia</dc:creator>
	<dc:creator>Naini, Al Arofatus</dc:creator>
	<dc:creator>Mayanti, Tri</dc:creator>
	<dc:creator>Lesmana, Ronny</dc:creator>
	<dc:creator>Azmi, Mohamad Nurul</dc:creator>
	<dc:creator>Supratman, Unang</dc:creator>
	<dc:description xml:lang="en-US">Dysoxylum alliaceum belongs to the Dysoxylum genus (Meliaceae) and there are few reports concerning the phytochemical components of this plant. To examine the chemical constituents of Dysoxylum alliaceum stem bark, a phytochemical study has been conducted and identified five known steroids, 3β,16β-dihydroxy-24(S)-methyl cholestenol (1), ergosta-5,22-dien-3β-ol (2), ergosta-7,24(28)-dien-3β-ol (3), 22(E)-ergosta-6,22-dien-3β,5α,8α-triol (4), and 20α-dihydroprogesterone (5) from its ethanolic extract. Spectroscopic data such as FT-IR, HR-ESI-MS, 1D, and 2D NMR as well as comparison with previously published spectral data were used to identify the chemical structures of compounds 1–5. &amp;nbsp;Furthermore, these steroids 1-5 were assessed in vitro regarding their cytotoxic effect against A549 lung cancer cell lines and revealed weak to inactive with IC50 values ranging from 68.52 to &amp;gt;150 µM.
Keywords: A549 cell lines, cytotoxic evaluation, Dysoxylum alliaceum (blume) blume ex a.juss, meliaceae, steroid</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Jenderal Soedirman</dc:publisher>
	<dc:date>2024-11-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
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	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jos.unsoed.ac.id/index.php/jm/article/view/11439</dc:identifier>
	<dc:identifier>10.20884/1.jm.2024.19.3.11439</dc:identifier>
	<dc:source xml:lang="en-US">Molekul; Vol 19 No 3 (2024); 471-480</dc:source>
	<dc:source>2503-0310</dc:source>
	<dc:source>1907-9761</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jos.unsoed.ac.id/index.php/jm/article/view/11439/5879</dc:relation>
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