Dammarane-Type Triterpenoids from Twigs of Aglaia Foveolata and Their Antibacterial Activity

Hutagaol, Ricson Pemimpin; Mozef, Tjandrawati; Nurilmala, Febi; Primahana, Gian; Fajriah, Sofa; Prastya, Muhammad Eka; Hidayatullah, Sigit; Satyaningsih, Desy

doi:10.20884/1.jm.2025.20.2.16241

Jurnal SINTA 1

Dammarane-Type Triterpenoids from Twigs of Aglaia Foveolata and Their Antibacterial Activity

Molekul: Jurnal Ilmiah Kimia · Vol. 20 No. 2 (2025) · hlm. 394–403

DOI: 10.20884/1.jm.2025.20.2.16241
ISSN: 2503-0310, 1907-9761
Terbit: 2025-07-24
Penerbit: Universitas Jenderal Soedirman
Bahasa: eng

Abstrak

ABSTRACT. The Aglaia species, which contains triterpenoids, is the most numerous in the Meliaceae family. Aglaia foveolata (A. foveolata) is a type of plant that has many benefits, as medicinal ingredients. The potential of this plant is inseparable from the content of various bioactive compounds. This study aims to isolate, characterize the active compound from the twigs of A. foveolata and test its activity as an antibacterial. Three dammarane-type triterpenoids were isolated from the A. foveolata twigs which is, namely dammar-24-en-3β,20-diol (1), an epimeric mixture of shoreic and eichlerianic acid (2, 3). Their chemical structures were determined based on spectroscopic data using infrared, high-resolution mass spectrometry, and including one and two-dimensional NMR techniques, as well as through data comparison of the reported compound. Compound 1 was reported for the first time to be successfully isolated from this species. All these substances were tested for the first time for their antibacterial activity against two Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis and two Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, through this study. Compound 1 was inactive, the epimeric mixture of 2 and 3 showed moderate antibacterial activity with a minimum inhibitory concentration (MIC) value ranging from 31.7 to 126.6 ppm, particularly against S. aureus with a MIC value of 31.7 ppm. Keywords: Aglaia, Elucidation, Isolation, Spectroscopy, Bacterial

Jaringan kolaborasi para penulis

40 penulis · 219 tautan kepenulisan bersama · 143 lintas organisasi · menampilkan 40 yang paling banyak terhubung

Arahkan kursor atau ketuk sebuah nama untuk menyorot rekan penulisnya. Klik dua kali untuk membuka halaman penulis.

Padjadjaran University
National Research and Innovation Agency
Universitas Nusa Bangsa
Indonesian Institute of Sciences
IPB University
Yamagata University
Maranatha Christian University
Organisasi lain
Afiliasi tidak diketahui

Organisasi berbeda
Organisasi sama
Afiliasi tidak diketahui
Garis lebih tebal = lebih banyak artikel bersama · lingkaran lebih besar = lebih banyak artikel

Tampilkan sebagai tabel

Rekan penulis	Organisasi	Artikel bersama
Unang Supratman	Padjadjaran University	15
Desi Harneti	Padjadjaran University	9
Yoshihito Shiono	Yamagata University	9
Ace Tatang Hidayat	Padjadjaran University	8
Tri Mayanti	Padjadjaran University	7
Al Arofatus Naini	Padjadjaran University	7
Kindi Farabi	Padjadjaran University	6
Nurlelasari Nurlelasari	Padjadjaran University	5
Vera Permatasari	National Research and Innovation Agency	5
Khalijah Awang	University of Malaya	5
Wahyu Widowati	Maranatha Christian University	4
Jepri Agung Priyanto	IPB University	4
Erma Suryanti	Sumatera Institute of Technology	4
Erina Hilmayanti	Padjadjaran University	3
Dewa Gede Katja	Sam Ratulangi University	3
Mohamad Nurul Azmi	Universiti Sains Malaysia	3
Rani Maharani	Padjadjaran University	3
Ahmad Randy	National Research and Innovation Agency	3
Irmanida Batubara	IPB University	3
Akhmad Darmawan	Indonesian Institute of Sciences	3
Indri Yati	National Research and Innovation Agency	3
Indah Dwiatmi Dewijanti	Indonesian Institute of Sciences	3
Novita Ariani	National Research and Innovation Agency	3
Ervi Afifah	Afiliasi tidak diketahui	2
Rizal Rizal	University of Indonesia	2
Chandra Risdian	Indonesian Institute of Sciences	2
Ferry Sandra	Universitas Trisakti	2
Tati Nurhayati	IPB University	2
Gian Primahana	Afiliasi tidak diketahui	2
‪Tati Nurhayati	IPB University	2
Darwati Darwati	Padjadjaran University	2
Harizon Harizon	Universitas Jambi	2

Afiliasi berasal dari OpenAlex; metadata OAI-PMH jurnal tidak memuatnya. Penulis tanpa ID OpenAlex dicocokkan berdasarkan nama, sehingga dua orang bisa tergabung atau satu orang bisa terpisah.

Sumber metadata: OAI-PMH (metadata jurnal) https://jos.unsoed.ac.id/index.php/jm/oai, pertama di-harvest 9 Nov 2026, terakhir terlihat 9 Nov 2026.

Metadata asli (oai_dc)

<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US"> Dammarane-Type Triterpenoids from Twigs of Aglaia Foveolata and Their Antibacterial Activity</dc:title>
	<dc:creator>Hutagaol, Ricson Pemimpin</dc:creator>
	<dc:creator>Mozef, Tjandrawati</dc:creator>
	<dc:creator>Nurilmala, Febi</dc:creator>
	<dc:creator>Primahana, Gian</dc:creator>
	<dc:creator>Fajriah, Sofa</dc:creator>
	<dc:creator>Prastya, Muhammad Eka</dc:creator>
	<dc:creator>Hidayatullah, Sigit</dc:creator>
	<dc:creator>Satyaningsih, Desy</dc:creator>
	<dc:description xml:lang="en-US">ABSTRACT. The Aglaia species, which contains triterpenoids, is the most numerous in the Meliaceae family. Aglaia foveolata (A. foveolata) is a type of plant that has many benefits, as medicinal ingredients. The potential of this plant is inseparable from the content of various bioactive compounds. This study aims to isolate, characterize the active compound from the twigs of A. foveolata and test its activity as an antibacterial. Three dammarane-type triterpenoids were isolated from the A. foveolata twigs which is, namely dammar-24-en-3β,20-diol (1), an epimeric mixture of shoreic and eichlerianic acid (2, 3). Their chemical structures were determined based on spectroscopic data using infrared, high-resolution mass spectrometry, and including one and two-dimensional NMR techniques, as well as through data comparison of the reported compound. Compound 1 was reported for the first time to be successfully isolated from this species. All these substances were tested for the first time for their antibacterial activity against two Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis and two Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, through this study. Compound 1 was inactive, the epimeric mixture of 2 and 3 showed moderate antibacterial activity with a minimum inhibitory concentration (MIC) value ranging from 31.7 to 126.6 ppm, particularly against S. aureus with a MIC value of 31.7 ppm. &amp;nbsp;
&amp;nbsp;
Keywords: Aglaia, Elucidation, Isolation, Spectroscopy, Bacterial</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Jenderal Soedirman</dc:publisher>
	<dc:date>2025-07-24</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://jos.unsoed.ac.id/index.php/jm/article/view/16241</dc:identifier>
	<dc:identifier>10.20884/1.jm.2025.20.2.16241</dc:identifier>
	<dc:source xml:lang="en-US">Molekul; Vol 20 No 2 (2025); 394-403</dc:source>
	<dc:source>2503-0310</dc:source>
	<dc:source>1907-9761</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://jos.unsoed.ac.id/index.php/jm/article/view/16241/7178</dc:relation>
</oai_dc:dc>