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Antihyperlipidemic Activity of Ethanol Extract Mindi’s Leaves (Melia azedarach Linn.) in Male Wistar Rats Induced Propiltiouracil

Science and Technology Indonesia · Vol. 4 No. 1 (2019) · hlm. 24–30

DOI
10.26554/sti.2019.4.1.24-30
ISSN
2580-4391, 2580-4405
Terbit
2019-01-27
Penerbit
Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya
Bahasa
eng

Abstrak

Mindi’s leaves (Melia azedarach Linn.) is an Indonesian medicinal plant that used as traditional medicine. Mindi leaves contains some secondary metabolites which have potency to decreased total cholesterol and LDL level. The study purposed to know antihyperlipidemic effect of ethanol extract of mindi’s leaves (Melia azedarach Linn.) seen from total cholesterol, and LDL in male albino rats. Male wistar albino rats were divided into 5 groups, negative control group (sodium CMC 0.5%), positive control group (simvastatin 0.193 mg/200 gBW), group I (ethanol extract mindi’s leaves with dosage 300 mg/200 gBW), group II (ethanol extract mindi’s leaves with dosage 600 mg/200 gBW), and group III (ethanol extract mindi’s leaves with dosage 1200 mg/200 gBW). The rats were given high-fat supplement and propylthiouracil for 15 days to increase cholesterol, and the extract was given for the next 15 days. Average cholesterol level, LDL, and body weight after induction was 90.28 mg/dL, 31.09 mg/dL, and 222.32 g. The result showed ethanol extract mindi’s leaves could decreased total cholesterol level and LDL level with % decreased in total cholesterol (%PDTC) and % decreased in LDL (%PDLDL) of group I is 37.78% and 35.57%, group II is 45.99% and 40.39%, and for group III is 56.29% and 52.42%. The result showed that ethanol extract of mindi’s leaves has antihyperlipidemic activity and significantly different from negative control (p>0.05). Based on the percentage relation of decreased total cholesterol and LDL levels to dose, then the effective dose 50 (ED50) value of ethanol extract mindi’s leave is 869 mg/200 gBW for total cholesterol and for LDL reduction level is 1086.84 mg/200 gBW

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Rekan penulisOrganisasiArtikel bersama
Mardiyanto MardiyantoSriwijaya University2
Soilia FertilitaSriwijaya University2
Oktia CharmilaSriwijaya University2
Indah SolihahAfiliasi tidak diketahui1
Annisa AmrianiAfiliasi tidak diketahui1
Rizky SintyaAfiliasi tidak diketahui1

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Sumber metadata: OAI-PMH (metadata jurnal) http://sciencetechindonesia.com/index.php/jsti/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">Antihyperlipidemic Activity of Ethanol Extract Mindi’s Leaves  (Melia azedarach Linn.) in Male Wistar Rats Induced Propiltiouracil</dc:title>
	<dc:creator>Herlina, Herlina</dc:creator>
	<dc:creator>Untari, Budi</dc:creator>
	<dc:creator>Solihah, Indah</dc:creator>
	<dc:creator>Santia, Merie</dc:creator>
	<dc:subject xml:lang="en-US">Melia azedarach Linn., antihyperlipidemia, total cholesterol, low density lipoprotein (LDL)</dc:subject>
	<dc:description xml:lang="en-US">Mindi’s leaves (Melia azedarach Linn.) is an Indonesian medicinal plant that used as traditional medicine. Mindi leaves contains some secondary metabolites which have potency to decreased total cholesterol and LDL level. The study purposed to know antihyperlipidemic effect of ethanol extract of mindi’s leaves (Melia azedarach Linn.) seen from total cholesterol, and LDL in male albino rats. Male wistar albino rats were divided into 5 groups, negative control group (sodium CMC 0.5%), positive control group (simvastatin 0.193 mg/200 gBW), group I (ethanol extract mindi’s leaves with dosage 300 mg/200 gBW), group II (ethanol extract mindi’s leaves with dosage 600 mg/200 gBW), and group III (ethanol extract mindi’s leaves with dosage 1200 mg/200 gBW). The rats were given high-fat supplement and propylthiouracil for 15 days to increase cholesterol, and the extract was given for the next 15 days. Average cholesterol level, LDL, and body weight after induction was 90.28 mg/dL, 31.09 mg/dL, and 222.32 g. The result showed ethanol extract mindi’s leaves could decreased total cholesterol level and LDL level with % decreased in total cholesterol (%PDTC) and % decreased in LDL (%PDLDL) of group I is 37.78% and 35.57%, group II is 45.99% and 40.39%, and for group III is 56.29% and 52.42%. The result showed that ethanol extract of mindi’s leaves has antihyperlipidemic activity and significantly different from negative control (p&amp;gt;0.05). Based on the percentage relation of decreased total cholesterol and LDL levels to dose, then the effective dose 50 (ED50) value of ethanol extract mindi’s leave is 869 mg/200 gBW for total cholesterol and for LDL reduction level is 1086.84 mg/200 gBW</dc:description>
	<dc:publisher xml:lang="en-US">Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya</dc:publisher>
	<dc:date>2019-01-27</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:type xml:lang="en-US">Peer-reviewed Article</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>http://sciencetechindonesia.com/index.php/jsti/article/view/156</dc:identifier>
	<dc:identifier>10.26554/sti.2019.4.1.24-30</dc:identifier>
	<dc:source xml:lang="en-US">Science and Technology Indonesia; Vol. 4 No. 1 (2019): January; 24-30</dc:source>
	<dc:source>2580-4391</dc:source>
	<dc:source>2580-4405</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>http://sciencetechindonesia.com/index.php/jsti/article/view/156/100</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2019 Herlina Herlina, Budi Untari, Indah Solihah, Merie Santia</dc:rights>
</oai_dc:dc>