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EFFECT OF COMBINING PHALERIA MACROCARPA AND AVERRHOA BILIMBI L ON FASTING BLOOD GLUCOSE LEVES IN A RAT MODEL OF TYPE 2 DIABETES MELLITUS

The Indonesian Journal of Public Health · Vol. 20 No. 2 (2025) · hlm. 316–327

DOI
10.20473/ijph.v20i2.2025.316-327
ISSN
2540-8836, 1829-7005
Terbit
2025-08-01
Penerbit
Universitas Airlangga
Bahasa
eng
Lisensi
creativecommons.org/licenses/by-nc-sa/4.0

Abstrak

Introduction: Diabetes is a serious problem, and a solution is being sought. Traditional ingredients have been proven to contain many substances that can be used to prevent and treat diabetes. This study aimed to investigate the effects of a combination of Phaleria macrocarpa and Averrhoa bilimbi L extracts on fasting blood glucose levels. Methods: A randomized, post-test-controlled group design was used. Type 2 diabetes mellitus was induced in 36 Sprague Dawley rats by feeding them a high-fat diet for 2 weeks, followed by the administration of streptozotocin and nicotinamide to induce type 2 Diabetes Mellitus. The rats were divided into six groups: CN, C-, C+, T1, T2, and T3. The treatment was administered for 21 days, and fasting blood glucose levels were measured. The data were analyzed using One-Way ANOVA with post-hoc Tukey's HSD test. Results: The combined dose of Phaleria macrocarpa and Averrhoa bilimbi Lextract effectively reduced fasting blood glucose levels over a 21-day period. Group T1 demonstrated the highest efficacy and did not differ significantly from that of the C+ group. The effective dosage that influenced fasting blood glucose levels was a combination of Phaleria macroca at 750 mg/kg W/day and Averrhoa bilimbi L at 375 mg/kg. Conclusion: Phaleria macrocarpa and Averrhoa bilimbi L extract have a synergistic effect that makes them a promising natural medication for controlling blood glucose levels. Further investigation is required to investigate the underlying mechanisms and assess the long-term consequences of this combination therapy.

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  • Universitas Syiah Kuala
  • Universitas Islam Negeri Ar-Raniry
  • Poltekkes Kemenkes Banjarmasin
  • Sunan Kalijaga State Islamic University Yogyakarta
  • Universitas Islam Negeri Sumatera Utara
  • Universitas Islam Negeri Alauddin Makassar
  • Institut Agama Islam Negeri Bone
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Rekan penulisOrganisasiArtikel bersama
Niken Widyastuti HariatiPoltekkes Kemenkes Banjarmasin3
Malahayati MalahayatiUniversitas Islam Negeri Ar-Raniry2
Chairunnisa DjayadinSunan Kalijaga State Islamic University Yogyakarta1
Khairan ARUniversitas Islam Negeri Ar-Raniry1
Mawardi MawardiUniversitas Islam Negeri Ar-Raniry1
Malahayati UmarUniversitas Islam Negeri Ar-Raniry1
Mouliza AstariUniversitas Islam Negeri Ar-Raniry1
Fathiah FathiahUniversitas Islam Negeri Ar-Raniry1
Arika Dhien SartikaAfiliasi tidak diketahui1
Muhammad Rizal FachriUniversitas Islam Negeri Ar-Raniry1
Habibi AkbarUniversitas Syiah Kuala1
Ramdhan Halid SiregarUniversitas Syiah Kuala1
Rika Sri UtamiUniversitas Syiah Kuala1
Mahdi SyukriUniversitas Syiah Kuala1
Nurhayati NurhayatiUniversitas Islam Negeri Sumatera Utara1
Abdullah AbdullahUniversitas Islam Negeri Ar-Raniry1
Fadli Andi NatsifUniversitas Islam Negeri Alauddin Makassar1
Hasbi SiddikInstitut Agama Islam Negeri Bone1
Khairun SaddamiUniversitas Syiah Kuala1
Rika Sri UtamiUniversitas Syiah Kuala1
Akhyar AkhyarUniversitas Syiah Kuala1

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Sumber metadata: OAI-PMH (metadata jurnal) https://e-journal.unair.ac.id/IJPH/oai, pertama di-harvest 10 Nov 2026, terakhir terlihat 10 Nov 2026.
Metadata asli (oai_dc) 
<oai_dc:dc xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/  http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
	<dc:title xml:lang="en-US">EFFECT OF COMBINING PHALERIA MACROCARPA AND AVERRHOA BILIMBI L ON FASTING BLOOD GLUCOSE LEVES IN A RAT MODEL OF TYPE 2 DIABETES MELLITUS</dc:title>
	<dc:creator>Laila Sholehah</dc:creator>
	<dc:creator>Fathurrahman Fathurrahman</dc:creator>
	<dc:creator>Widyastuti Hartati, Niken</dc:creator>
	<dc:creator>Aprianti Aprianti</dc:creator>
	<dc:subject xml:lang="en-US">Averrhoa Bilimbi L</dc:subject>
	<dc:subject xml:lang="en-US">Phaleria Macrocarpa</dc:subject>
	<dc:subject xml:lang="en-US">Diabetes Mellitus</dc:subject>
	<dc:subject xml:lang="en-US">Fasting Blood Glucose</dc:subject>
	<dc:subject xml:lang="en-US">Rat</dc:subject>
	<dc:description xml:lang="en-US">
Introduction: Diabetes is a serious problem, and a solution is being sought. Traditional ingredients have been proven to contain many substances that can be used to prevent and treat diabetes. This study aimed to investigate the effects of a combination of Phaleria macrocarpa and Averrhoa bilimbi L extracts on fasting blood glucose levels. Methods: A randomized, post-test-controlled group design was used. Type 2 diabetes mellitus was induced in 36 Sprague Dawley rats by feeding them a high-fat diet for 2 weeks, followed by the administration of streptozotocin and nicotinamide to induce type 2 Diabetes Mellitus. The rats were divided into six groups: CN, C-, C+, T1, T2, and T3. The treatment was administered for 21 days, and fasting blood glucose levels were measured. The data were analyzed using One-Way ANOVA with post-hoc Tukey's HSD test. Results: The combined dose of Phaleria macrocarpa and Averrhoa bilimbi Lextract effectively reduced fasting blood glucose levels over a 21-day period. Group T1 demonstrated the highest efficacy and did not differ significantly from that of the C+ group. The effective dosage that influenced fasting blood glucose levels was a combination of Phaleria macroca at 750 mg/kg W/day and Averrhoa bilimbi L at 375 mg/kg. Conclusion: Phaleria macrocarpa and Averrhoa bilimbi L extract have a synergistic effect that makes them a promising natural medication for controlling blood glucose levels. Further investigation is required to investigate the underlying mechanisms and assess the long-term consequences of this combination therapy.
</dc:description>
	<dc:publisher xml:lang="en-US">Universitas Airlangga</dc:publisher>
	<dc:date>2025-08-01</dc:date>
	<dc:type>info:eu-repo/semantics/article</dc:type>
	<dc:type>info:eu-repo/semantics/publishedVersion</dc:type>
	<dc:format>application/pdf</dc:format>
	<dc:identifier>https://e-journal.unair.ac.id/IJPH/article/view/59092</dc:identifier>
	<dc:identifier>10.20473/ijph.v20i2.2025.316-327</dc:identifier>
	<dc:source xml:lang="en-US">The Indonesian Journal of Public Health; Vol. 20 No. 2 (2025): THE INDONESIAN JOURNAL OF PUBLIC HEALTH; 316-327</dc:source>
	<dc:source>2540-8836</dc:source>
	<dc:source>1829-7005</dc:source>
	<dc:language>eng</dc:language>
	<dc:relation>https://e-journal.unair.ac.id/IJPH/article/view/59092/33804</dc:relation>
	<dc:rights xml:lang="en-US">Copyright (c) 2025 The Indonesian Journal of Public Health</dc:rights>
	<dc:rights xml:lang="en-US">https://creativecommons.org/licenses/by-nc-sa/4.0</dc:rights>
</oai_dc:dc>